DRG1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DRG1_MOUSE
• UniProt AC: P32233
• Protein Name: Developmentally-regulated GTP-binding protein 1
• Gene Name: Drg1
• Organism: Mus musculus (Mouse).
• Sequence Length: 367
• Subcellular Localization: Cytoplasm. The DRG1-DFRP2/ZC3H15 complex associates with polysomes..
• Protein Description: Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest..
• Protein Sequence: MSGTLAKIAEIEAEMARTQKNKATAHHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKIIENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQSELDAETVKSILAEYKIHNADVTLRSDATADDLIDVVEGNRVYIPCIYVLNKIDQISIEELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLKLVRIYTKPKGQLPDYTSPVVLPYSRTTVEDFCMKIHKNLIKEFKYALVWGLSVKHNPQKVGKDHTLEDEDVIQIVKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGTLAKIA ------CCCHHHHHH	40.25	-
7	Ubiquitination	-MSGTLAKIAEIEAE -CCCHHHHHHHHHHH	45.63	22790023
22	Hydroxylation	MARTQKNKATAHHLG HHHHHHCHHHHHHHH	54.90	-
46	Ubiquitination	RRELITPKGGGGGGP HHHHCCCCCCCCCCC	62.63	22790023
100	Phosphorylation	AYEFTTLTTVPGVIR CEECCCCCCCCCEEE	24.53	-
112	Ubiquitination	VIRYKGAKIQLLDLP EEEECCCEEEEEECC	39.39	22790023
126	Ubiquitination	PGIIEGAKDGKGRGR CCHHCCCCCCCCCCH	77.27	22790023
159	Ubiquitination	LKPLGHKKIIENELE HHHHCCHHHHHCHHC	43.15	22790023
175	Ubiquitination	FGIRLNSKPPNIGFK CCEECCCCCCCCCCC	64.52	22790023
186	Ubiquitination	IGFKKKDKGGINLTA CCCCCCCCCCEECEE	68.84	-
213	Ubiquitination	KSILAEYKIHNADVT HHHHHHHCCCCCCEE	29.06	22790023
290	Ubiquitination	EKIWDYLKLVRIYTK HHHHHHHHHHHHCCC	38.41	22790023
299	Ubiquitination	VRIYTKPKGQLPDYT HHHCCCCCCCCCCCC	61.93	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
100	T	Phosphorylation	Kinase	STK16	O88697	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
22	K	Hydroxylation	Hydroxylated (with S stereochemistry) at C-3 of Lys-22 by JMJD7.	-
100	T	Phosphorylation	Phosphorylated at Thr-100 by STK16.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DRG1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZC3HF_MOUSE	Zc3h15	physical	15676025

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.