ZC3HF_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZC3HF_MOUSE
• UniProt AC: Q3TIV5
• Protein Name: Zinc finger CCCH domain-containing protein 15
• Gene Name: Zc3h15
• Organism: Mus musculus (Mouse).
• Sequence Length: 426
• Subcellular Localization: Cytoplasm. Nucleus. The DRG1-DFRP2/ZC3H15 complex associates with polysomes..
• Protein Description: Protects DRG1 from proteolytic degradation..
• Protein Sequence: MPPKKQAQAGGSKKAEQKKKEKIIEDKTFGLKNKKGAKQQKFIKAVTHQVKFGQQNPRQVAQSEAEKKLKKDDKKKELQELNELFKPVVAAQKISKGADPKSVVCAFFKQGQCTKGDKCKFSHDLTLERKCEKRSVYIDARDEELEKDTMDNWDEKKLEEVVNKKHGEAEKKKPKTQIVCRHFLEAIENNKYGWFWVCPGGGDNCMYRHALPPGFVLKKDKKKEEKEDEISLEDLIERERSALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMERRKADFKAGKALVISGREVFEFRPELVNDDDEEADDTRYIQGTGGDEVDDSMGVNDIDISLYVPRDVEETGITVASVERFSTYAPDKDENKLSEASGGLAENGERSDLDEDSGGGGQENGSIDAVPVDENLFTGEDLDELEEELNTLDLEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Ubiquitination	KEKIIEDKTFGLKNK HHHHHHCCCCCCCCC	32.72	27667366
27	Acetylation	KEKIIEDKTFGLKNK HHHHHHCCCCCCCCC	32.72	23806337
44	Ubiquitination	AKQQKFIKAVTHQVK HHHHHHHHHHHHHHH	39.68	27667366
51	Ubiquitination	KAVTHQVKFGQQNPR HHHHHHHHCCCCCHH	36.89	27667366
86	Ubiquitination	QELNELFKPVVAAQK HHHHHHHHHHHHHHH	49.91	-
93	Ubiquitination	KPVVAAQKISKGADP HHHHHHHHHHCCCCC	44.19	27667366
95	Phosphorylation	VVAAQKISKGADPKS HHHHHHHHCCCCCCC	31.88	29514104
135	Phosphorylation	ERKCEKRSVYIDARD CCHHHCCCEEEECCC	30.27	25338131
137	Phosphorylation	KCEKRSVYIDARDEE HHHCCCEEEECCCHH	8.37	29514104
231	Phosphorylation	EEKEDEISLEDLIER HHCCCCCCHHHHHHH	24.53	25521595
285	Malonylation	KADFKAGKALVISGR HHHHHCCCEEEECCC	43.33	26320211
348	Phosphorylation	DVEETGITVASVERF CHHHHCCEEEEEEEE	16.03	25619855
351	Phosphorylation	ETGITVASVERFSTY HHCCEEEEEEEEECC	21.85	25619855
362	Acetylation	FSTYAPDKDENKLSE EECCCCCCCCCCHHH	66.92	23954790
368	Phosphorylation	DKDENKLSEASGGLA CCCCCCHHHHCCCCC	32.50	26370283
371	Phosphorylation	ENKLSEASGGLAENG CCCHHHHCCCCCCCC	29.37	26370283
381	Phosphorylation	LAENGERSDLDEDSG CCCCCCCCCCCCCCC	37.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZC3HF_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZC3HF_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZC3HF_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ZC3HF_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.