dbPTM

COPZ2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	COPZ2_MOUSE
UniProt AC	Q9JHH9
Protein Name	Coatomer subunit zeta-2
Gene Name	Copz2
Organism	Mus musculus (Mouse).
Sequence Length	205
Subcellular Localization	Cytoplasm, cytosol . Endoplasmic reticulum-Golgi intermediate compartment membrane Peripheral membrane protein Cytoplasmic side. Golgi apparatus membrane Peripheral membrane protein Cytoplasmic side . Cytoplasmic vesicle, COPI-coated vesicle membran
Protein Description	The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity)..
Protein Sequence	MQRPEAWPRPHPGEGASAAQAGGAAPPTRATEQREPSLYTIKAVFILDNDGRRLLAKYYDDTFPSVKEQMVFEKNVFNKTSRTESEIAFLGGMTIVYKSSIDIFLYVVGSSSENELMLMSVLACLFDSLSHILRKNVEKRWLLENMDGAFLVLDETVDGGVILESDPQQVIQKVNFRTDDSGLTEQSVAQVLQSAKEQIKWSLLK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
57	Acetylation	DGRRLLAKYYDDTFP CCCHHHHHHHCCCCC	44.29	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of COPZ2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of COPZ2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of COPZ2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of COPZ2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of COPZ2_MOUSE

Related Literatures of Post-Translational Modification