KBL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KBL_MOUSE
• UniProt AC: O88986
• Protein Name: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
• Gene Name: Gcat
• Organism: Mus musculus (Mouse).
• Sequence Length: 416
• Subcellular Localization: Mitochondrion. Nucleus. Translocates to the nucleus upon cold and osmotic stress..
• Protein Sequence: MWASFMWHGALSPGRRAHSALAQLRCILDSELEGIRGAGTWKSERVITSRQGPSIRVDGISGGILNFCANNYLGLSSHPAVIQAGLQTLEEFGAGLSSTRFICGTQSIHKNLEAKIAHFHQREDAILYPSCFDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLDMADLEAKLKEAQKHRLRLVATDGAFSMDGDIAPLQDICRLAAQYGALVFVDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPEPLVSLLRQRSRPYLFSNSLPPAVVGCASKALDLLMESNAIIQSMAAKTRRFRSKMEAAGFTVSGADHPICPVMLGDARLSSQMADDMLKKGIFVIGFSYPVVPKGKARIRVQISAVHSEEDIDRCVEAFVEVGRLHGALP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	S-palmitoylation	SALAQLRCILDSELE HHHHHHHHHHHHHCC	5.01	28526873
42	Succinylation	IRGAGTWKSERVITS CCCCCCEECCEEEEC	42.13	-
42	Glutarylation	IRGAGTWKSERVITS CCCCCCEECCEEEEC	42.13	24703693
42	Succinylation	IRGAGTWKSERVITS CCCCCCEECCEEEEC	42.13	23806337
42	Acetylation	IRGAGTWKSERVITS CCCCCCEECCEEEEC	42.13	23576753
103	S-palmitoylation	LSSTRFICGTQSIHK CCCCCEEECCHHHHH	4.42	28526873
115	Ubiquitination	IHKNLEAKIAHFHQR HHHCHHHHHHHHHHC	30.93	22790023
167	Acetylation	IDGIRLCKAHKYRYR HHHHHHHHHHHCHHC	59.11	23201123
170	Acetylation	IRLCKAHKYRYRHLD HHHHHHHHCHHCCCC	35.96	23201123
184	Acetylation	DMADLEAKLKEAQKH CHHHHHHHHHHHHHH	51.20	23576753
184	Succinylation	DMADLEAKLKEAQKH CHHHHHHHHHHHHHH	51.20	-
184	Glutarylation	DMADLEAKLKEAQKH CHHHHHHHHHHHHHH	51.20	24703693
184	Ubiquitination	DMADLEAKLKEAQKH CHHHHHHHHHHHHHH	51.20	-
184	Succinylation	DMADLEAKLKEAQKH CHHHHHHHHHHHHHH	51.20	23806337
186	Acetylation	ADLEAKLKEAQKHRL HHHHHHHHHHHHHCC	50.74	23864654
190	Acetylation	AKLKEAQKHRLRLVA HHHHHHHHHCCEEEE	37.43	23201123
215	S-palmitoylation	IAPLQDICRLAAQYG CHHHHHHHHHHHHHC	3.82	28526873
262	N6-(pyridoxal phosphate)lysine	IINSTLGKALGGASG EEECHHHHHHCCCCC	43.48	-
262	Other	IINSTLGKALGGASG EEECHHHHHHCCCCC	43.48	-
323	Succinylation	IIQSMAAKTRRFRSK HHHHHHHHHHHHHHH	32.78	-
323	Acetylation	IIQSMAAKTRRFRSK HHHHHHHHHHHHHHH	32.78	23806337
323	Succinylation	IIQSMAAKTRRFRSK HHHHHHHHHHHHHHH	32.78	23806337
346	S-palmitoylation	SGADHPICPVMLGDA CCCCCCCCCHHCCCH	2.15	28526873
365	Succinylation	QMADDMLKKGIFVIG HHHHHHHHCCEEEEE	42.17	23806337
365	Succinylation	QMADDMLKKGIFVIG HHHHHHHHCCEEEEE	42.17	-
365	Acetylation	QMADDMLKKGIFVIG HHHHHHHHCCEEEEE	42.17	23201123
366	Acetylation	MADDMLKKGIFVIGF HHHHHHHCCEEEEEE	53.96	23201123
380	Succinylation	FSYPVVPKGKARIRV ECCCCCCCCEEEEEE	62.53	23806337
380	Succinylation	FSYPVVPKGKARIRV ECCCCCCCCEEEEEE	62.53	-
380	Acetylation	FSYPVVPKGKARIRV ECCCCCCCCEEEEEE	62.53	23576753
382	Acetylation	YPVVPKGKARIRVQI CCCCCCCEEEEEEEE	40.39	23864654

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KBL_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KBL_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KBL_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KBL_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.