HMDH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HMDH_MOUSE
• UniProt AC: Q01237
• Protein Name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
• Gene Name: Hmgcr
• Organism: Mus musculus (Mouse).
• Sequence Length: 887
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins..
• Protein Sequence: MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTAEQAKVSLGLDEDVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLAFLLAVKYIFFEQAETESTLSLKNPITSPVVTSKKAQDNCCRREPLLVRRNQKLSSVEEDPGANQERKVEVIKPLVVEAETTSRATFVLGASVASPPSALGTQEPGIELPIEPRPNEECLQILENAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSTKLAEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEYQVPMATTEGCLVASTNRGCRAISLGGGASSRVLADGMTRGPVVRLPRACDSAEVKTWLETPEGFAVIKEAFDSTSRFARLQKLHVTMAGRNLYIRFQSRTGDAMGMNMISKGTEKALLKLQEFFPDMQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVLKTTTEAMVDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNRSKINLQDLQGTCTKKAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
89	Ubiquitination	NLRQLGSKYILGIAG CHHHHCHHHHHHHHH	34.22	-
142	Ubiquitination	SRASALAKFALSSNS HHHHHHHHHHHCCCC	31.83	22790023
142	Ubiquitination	SRASALAKFALSSNS HHHHHHHHHHHCCCC	31.83	22790023
248	Ubiquitination	VLEEEENKPNPVTQR HHHHHHCCCCCHHHH	49.83	22790023
248	Ubiquitination	VLEEEENKPNPVTQR HHHHHHCCCCCHHHH	49.83	22790023
281	N-linked_Glycosylation	IADPSPQNSTAEQAK CCCCCCCCCCHHHHH	44.72	-
355	Phosphorylation	LSLKNPITSPVVTSK ECCCCCCCCCCCCCH	28.38	28066266
356	Phosphorylation	SLKNPITSPVVTSKK CCCCCCCCCCCCCHH	19.20	28066266
381	Ubiquitination	LLVRRNQKLSSVEED CHHHCCCCCCCCCCC	54.61	22790023
381	Ubiquitination	LLVRRNQKLSSVEED CHHHCCCCCCCCCCC	54.61	22790023
383	Phosphorylation	VRRNQKLSSVEEDPG HHCCCCCCCCCCCCC	39.10	25338131
384	Phosphorylation	RRNQKLSSVEEDPGA HCCCCCCCCCCCCCC	43.94	25266776
459	Ubiquitination	ENAEKGAKFLSDAEI HHHHHHCCCCCHHHH	56.35	22790023
459	Ubiquitination	ENAEKGAKFLSDAEI HHHHHHCCCCCHHHH	56.35	22790023
473	Ubiquitination	IIQLVNAKHIPAYKL HHHHHCCCCCCCCHH	36.54	22790023
473	Ubiquitination	IIQLVNAKHIPAYKL HHHHHCCCCCCCCHH	36.54	22790023
479	Ubiquitination	AKHIPAYKLETLMET CCCCCCCHHHHHHHH	41.79	22790023
479	Ubiquitination	AKHIPAYKLETLMET CCCCCCCHHHHHHHH	41.79	22790023
501	Ubiquitination	RRQLLSTKLAEPSSL HHHHHCCCCCCCCCC	42.18	22790023
501	Ubiquitination	RRQLLSTKLAEPSSL HHHHHCCCCCCCCCC	42.18	22790023
663	Phosphorylation	MNMISKGTEKALLKL CEEECCCHHHHHHHH	37.74	-
871	Phosphorylation	SHMVHNRSKINLQDL HHCCCCCCCCCHHHH	43.11	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HMDH_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
248	K	ubiquitylation	Lys-248 is the main site of ubiquitination.	-
871	S	Phosphorylation	Phosphorylation at Ser-871 reduces the catalytic activity.	21183079

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HMDH_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HMDH_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.