RASL3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RASL3_MOUSE
• UniProt AC: Q8C2K5
• Protein Name: RAS protein activator like-3
• Gene Name: Rasal3
• Organism: Mus musculus (Mouse).
• Sequence Length: 1041
• Subcellular Localization: Cytoplasm . Cytoplasm, cell cortex .
• Protein Description: Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway..
• Protein Sequence: MKPECGQTMFRTFWSRSRDSSAMDPPLQSEEDSQTQPSLPSPLTSYRWHTGGSGEKAAGGFRWGRFAGWGRALSHQEPMVNSQPAPRSLFRRVLSAPPKESRSNRLRFSKTLWGRHKNVAPLEPKPNPKAPEPELELVADPDLPVAQIPEPPTPDMPVWNIDGFTLLEGKLVMLGEEEGPRQIRVGSASSENSMQAALGNLKDAVRTPGKTEPEAAGSNQVHNVRKLLKRLKEKKRAKSELGAYTPRDGPPSALGSRESLATLSELDLGAERDVRVWPLHPSLLGEPYCFQVTWAGGSLCFSCRSSAERDRWIEDLRRQFQPSQDNVERQEMWLTVWVHEAKGLPRATVPGVRAELWLDGALLARTAPRAGPGQLFWAERFHFEALPPARRLSLRLRSAGPAGATVGRVVLELDEVSIPRAPAAGLERWFPVLGAPAGAVLRARIRVRCLRVLPSERYKELAEFLTFHYARLCGALEPALSAQAKEELAAAMVRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQEYLQDTLGQVVRCLCASTEDCEVDPSKCPTPELPKHQARLRDSCEEVFENIIHSYNCFPAELGSVFSSWREACKARGSEALGPRLVCASLFLRLLCPAILAPSLFGLAPEHPAPGPARTLTLIAKVIQNLANCAPFGEKEAYMAFMNSFLEDHGPAMQHFLDQVATVDADTTPSGYQGSGDLALQLAVLHVQLCTIFAELDQKTQDSLEPLPTILRAIEEGRPVPVSVPMRLPRISTQVQSSFFSGEKPGFLAPRDLPKHTPLISKSQSLRSFQGAGSWASRRPDEERPQRRPRPVLRTQSVPARRPTHRRPSAGSKPRPKGSLRMGPAPCGRAWTRASASLPRKPSVPWQRQMDQPGDRYQTTGTHRPVGKLAEIQCEVAIFREAQKALSLLVESLSTQVQALKEQQEHFRCQLQDLYSRLGAGISKLDSKGGLPSNGSHRLKSLEQRLTEMECSQDQLRDSLQSLQLLSKTPGSRSQPLPLKAPCVNGADLSMGT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	FWSRSRDSSAMDPPL HHHCCCCCCCCCCCC	20.91	-
21	Phosphorylation	WSRSRDSSAMDPPLQ HHCCCCCCCCCCCCC	31.72	-
29	Phosphorylation	AMDPPLQSEEDSQTQ CCCCCCCCCCCCCCC	51.11	-
35	Phosphorylation	QSEEDSQTQPSLPSP CCCCCCCCCCCCCCC	46.53	-
38	Phosphorylation	EDSQTQPSLPSPLTS CCCCCCCCCCCCCCE	42.99	26745281
41	Phosphorylation	QTQPSLPSPLTSYRW CCCCCCCCCCCEECE	37.52	26745281
44	Phosphorylation	PSLPSPLTSYRWHTG CCCCCCCCEECEECC	27.39	26745281
45	Phosphorylation	SLPSPLTSYRWHTGG CCCCCCCEECEECCC	22.00	26745281
46	Phosphorylation	LPSPLTSYRWHTGGS CCCCCCEECEECCCC	16.70	26745281
50	Phosphorylation	LTSYRWHTGGSGEKA CCEECEECCCCCCCC	35.96	28066266
53	Phosphorylation	YRWHTGGSGEKAAGG ECEECCCCCCCCCCC	45.16	28066266
74	Phosphorylation	AGWGRALSHQEPMVN CCCCHHCCCCCCCCC	23.34	22942356
82	Phosphorylation	HQEPMVNSQPAPRSL CCCCCCCCCCCCHHH	26.57	28285833
95	Phosphorylation	SLFRRVLSAPPKESR HHHHHHHCCCCCCCC	35.55	28833060
101	Phosphorylation	LSAPPKESRSNRLRF HCCCCCCCCCCCCCC	47.32	28542873
103	Phosphorylation	APPKESRSNRLRFSK CCCCCCCCCCCCCCH	35.26	28542873
111	Phosphorylation	NRLRFSKTLWGRHKN CCCCCCHHHHCCCCC	26.92	27600695
187	Phosphorylation	PRQIRVGSASSENSM CCEEEECCCCCHHHH	23.32	22942356
189	Phosphorylation	QIRVGSASSENSMQA EEEECCCCCHHHHHH	39.62	22942356
190	Phosphorylation	IRVGSASSENSMQAA EEECCCCCHHHHHHH	40.28	21082442
193	Phosphorylation	GSASSENSMQAALGN CCCCCHHHHHHHHHC	14.28	21082442
207	Phosphorylation	NLKDAVRTPGKTEPE CHHHHHCCCCCCCCC	29.78	28066266
211	Phosphorylation	AVRTPGKTEPEAAGS HHCCCCCCCCCCCCC	63.79	22802335
239	Phosphorylation	KEKKRAKSELGAYTP HHHHHHHHHHCCCCC	36.75	28833060
245	Phosphorylation	KSELGAYTPRDGPPS HHHHCCCCCCCCCCC	16.00	24704852
252	Phosphorylation	TPRDGPPSALGSRES CCCCCCCCCCCCHHH	38.98	22942356
256	Phosphorylation	GPPSALGSRESLATL CCCCCCCCHHHHHHH	33.45	22942356
259	Phosphorylation	SALGSRESLATLSEL CCCCCHHHHHHHHHC	23.38	22942356
262	Phosphorylation	GSRESLATLSELDLG CCHHHHHHHHHCCCC	35.79	28833060
393	Phosphorylation	LPPARRLSLRLRSAG CCHHHHHHHHHHHCC	15.05	24704852
455	Phosphorylation	RCLRVLPSERYKELA HHEEECCHHHHHHHH	30.46	20139300
561	Phosphorylation	VVRCLCASTEDCEVD HHHHHHCCCCCCCCC	31.19	27600695
570	Phosphorylation	EDCEVDPSKCPTPEL CCCCCCHHHCCCCCC	42.29	26745281
574	Phosphorylation	VDPSKCPTPELPKHQ CCHHHCCCCCCCHHH	38.57	26745281
780	Phosphorylation	PMRLPRISTQVQSSF CCCCCCEEHHHHHHH	17.67	27600695
781	Phosphorylation	MRLPRISTQVQSSFF CCCCCEEHHHHHHHC	30.32	27600695
786	Phosphorylation	ISTQVQSSFFSGEKP EEHHHHHHHCCCCCC	17.14	27600695
805	Phosphorylation	PRDLPKHTPLISKSQ CCCCCCCCCCCCCCC	26.39	24704852
811	Phosphorylation	HTPLISKSQSLRSFQ CCCCCCCCCCCCCCC	20.43	25266776
813	Phosphorylation	PLISKSQSLRSFQGA CCCCCCCCCCCCCCC	32.61	21082442
816	Phosphorylation	SKSQSLRSFQGAGSW CCCCCCCCCCCCCCH	27.49	21082442
822	Phosphorylation	RSFQGAGSWASRRPD CCCCCCCCHHHCCCC	20.95	26745281
825	Phosphorylation	QGAGSWASRRPDEER CCCCCHHHCCCCCCC	23.67	28066266
843	Phosphorylation	RPRPVLRTQSVPARR CCCCCCCCCCCCCCC	22.49	28066266
845	Phosphorylation	RPVLRTQSVPARRPT CCCCCCCCCCCCCCC	29.47	28833060
852	Phosphorylation	SVPARRPTHRRPSAG CCCCCCCCCCCCCCC	26.63	25266776
857	Phosphorylation	RPTHRRPSAGSKPRP CCCCCCCCCCCCCCC	43.37	28066266
860	Phosphorylation	HRRPSAGSKPRPKGS CCCCCCCCCCCCCCC	38.92	30387612
880	Phosphorylation	APCGRAWTRASASLP CCCCCCCHHCCCCCC	18.51	27600695
883	Phosphorylation	GRAWTRASASLPRKP CCCCHHCCCCCCCCC	18.33	25266776
885	Phosphorylation	AWTRASASLPRKPSV CCHHCCCCCCCCCCC	36.09	25266776
891	Phosphorylation	ASLPRKPSVPWQRQM CCCCCCCCCCHHHCC	43.79	25266776
963	Phosphorylation	RCQLQDLYSRLGAGI HHHHHHHHHHHCCCC	10.47	-
981	Phosphorylation	DSKGGLPSNGSHRLK CCCCCCCCCCHHHHH	59.89	30635358
984	Phosphorylation	GGLPSNGSHRLKSLE CCCCCCCHHHHHHHH	15.08	30635358
989	Phosphorylation	NGSHRLKSLEQRLTE CCHHHHHHHHHHHHH	41.55	20495213

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RASL3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RASL3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RASL3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RASL3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.