PTCD3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTCD3_MOUSE
• UniProt AC: Q14C51
• Protein Name: Pentatricopeptide repeat domain-containing protein 3, mitochondrial
• Gene Name: Ptcd3
• Organism: Mus musculus (Mouse).
• Sequence Length: 685
• Subcellular Localization: Mitochondrion.
• Protein Description: Mitochondrial RNA-binding protein that has a role in mitochondrial translation..
• Protein Sequence: MAAAAVAARRLSFRSGLVLLQTTRGTGVCEPKVCCRFYAGTESLPKVEGSDITGIEEIVIPKKKTWDKVAVLQALASTVNRDPTAAPYVFHDDPYLIPTSALESRSFLLAKKSGETAAKFIINSYPKYFQKDIAEPHIPCLMPEYFEPQIEDVSEAALEERIRLRKVRASVDMFDQLLQAGTTVSLETTNSLLDLLCYYGDQEPPADYPFQQTEHLENLEEAAEENNQTSKMESGPWKAQNNAERIFALMPEKNARSYCTMIRGMVKHRAYAQALNVYTELLNNRLSADVYTFNALIEAKTFILNEKFEEKWNDILDLLKHMVAQKVKPNLQTFNTILKGLRKCYSLGRIPALQILREMKHIGIEPSLATYHHIIHLFYPRDLSAIKMPSLIIYDIMNELEGRTFSPQDLDDGRFFQLAMSVCSSLRDLELAYQVHRLLNTGDNRKLVGHDPLRKVYYSKFFSLICSLEQIDVTLKWYKDLIPSVFLPHYQIFIGLLQALDVANRLELVPQIWKDSKEYSHTFRDALREEVLMLMARDKHPPELQVAFADCAADIKSTYEDQSARQPAFDWPANPLQYIAVLFLRGGRSQEAWKMLELFKKHKKIPRNELLEEFMDTAKASGSTALAIEVVKLASAFSLPIGESLAQRVVMDFTVDPEQKEALGNLTELNSSDGESSSDSDSDDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
127	Acetylation	FIINSYPKYFQKDIA HHHHCCHHHHCCCCC	50.92	-
307	Acetylation	KTFILNEKFEEKWND HHHHHCHHHHHHHHH	57.93	23954790
311	Acetylation	LNEKFEEKWNDILDL HCHHHHHHHHHHHHH	44.06	22733758
328	Succinylation	HMVAQKVKPNLQTFN HHHHHHCCCCHHHHH	34.91	23806337
328	Acetylation	HMVAQKVKPNLQTFN HHHHHHCCCCHHHHH	34.91	23806337
594	Acetylation	GRSQEAWKMLELFKK CCCHHHHHHHHHHHH	40.43	23954790
600	Succinylation	WKMLELFKKHKKIPR HHHHHHHHHCCCCCH	67.60	23954790
617	Phosphorylation	LLEEFMDTAKASGST HHHHHHHHHHHCCCH	20.47	29899451
621	Phosphorylation	FMDTAKASGSTALAI HHHHHHHCCCHHHHH	32.35	29899451
623	Phosphorylation	DTAKASGSTALAIEV HHHHHCCCHHHHHHH	14.17	29899451
667	Phosphorylation	KEALGNLTELNSSDG HHHHCCCEECCCCCC	42.29	25619855
671	Phosphorylation	GNLTELNSSDGESSS CCCEECCCCCCCCCC	42.29	25619855
672	Phosphorylation	NLTELNSSDGESSSD CCEECCCCCCCCCCC	48.86	25619855
676	Phosphorylation	LNSSDGESSSDSDSD CCCCCCCCCCCCCCC	40.44	25619855
677	Phosphorylation	NSSDGESSSDSDSDD CCCCCCCCCCCCCCC	33.59	25619855
678	Phosphorylation	SSDGESSSDSDSDDK CCCCCCCCCCCCCCC	50.87	25619855
680	Phosphorylation	DGESSSDSDSDDK-- CCCCCCCCCCCCC--	40.75	27087446
682	Phosphorylation	ESSSDSDSDDK---- CCCCCCCCCCC----	52.22	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTCD3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTCD3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTCD3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PTCD3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.