AT12A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AT12A_MOUSE
• UniProt AC: Q9Z1W8
• Protein Name: Potassium-transporting ATPase alpha chain 2
• Gene Name: Atp12a
• Organism: Mus musculus (Mouse).
• Sequence Length: 1035
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues..
• Protein Sequence: MRRKTEIYSVELNGTKDVELADQKDDKKFKGGKNKDSEPNKSQEEELKKELDLDDHRLSNTDLEQKYGTNIIQGLSSIRAAELLARDGPNALTPPKQTPEIIKFLKQMVGGFSILLWIGAALCWIAYVIQYVSSTASLDNVYLGAILVLVVILTGIFAYYQEAKSTNIMASFSKMIPQQALVIRDAEKKIIPAEQLVVGDVVEIKGGDQIPADIRLVFSQGCKVDNSSLTGESEPQARSTEFTHENPLETKNIGFYSTTCLEGTATGIVINTGDRTIIGRIASLASGVGSEKTPIAIEIEHFVHIVAAVAVSVGVIFFITAVCMKYYVLDAIIFLISIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSENQTKQAFDQSSGTWASLSKIITLCNRAEFRPGQESVPIMKRVVVGDASETALLKFSEVILGDVMDIRKRNHKVAEIPFNSTNKFQLSIHETEDPNDKRFLMVMKGAPERILEKCSTIMINGQEQPLDKSSADAFHTAYMELGGLGERVLGFCHLYLPADKFPQSYTFDVDSINFPTSNLCFVGLLSMIDPPRSTVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANNETVEDIAKRRNIAVEQVNKREAKAAVVTGMELKDMTPEQLDELLINYQEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYTLTKNIAELCPFLIYIVAGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKKKDRLVNKQLAIYSYLHIGLMQALGGFLVYFTVYAQQGFWPTSLINLRVSWETDDINDLEDSYGQEWTRYQRKYLEWTGSTAFFVAIMVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGIISQIIVALVLSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEMRKLFIRLYPGSWWDKNMYY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MRRKTEIYSVELNGT CCCCCEEEEEECCCC	10.63	-
9	Phosphorylation	RRKTEIYSVELNGTK CCCCEEEEEECCCCC	18.12	-
59	Phosphorylation	DLDDHRLSNTDLEQK CCCCCCCCCCHHHHH	37.33	-
76	Phosphorylation	TNIIQGLSSIRAAEL CCHHHHHHHHHHHHH	30.46	25159016
77	Phosphorylation	NIIQGLSSIRAAELL CHHHHHHHHHHHHHH	22.57	25159016
93	Phosphorylation	RDGPNALTPPKQTPE HCCCCCCCCCCCCHH	34.82	24719451
98	Phosphorylation	ALTPPKQTPEIIKFL CCCCCCCCHHHHHHH	29.08	24719451
134	Phosphorylation	YVIQYVSSTASLDNV HHHHHHHCCCCCCHH	20.25	-
137	Phosphorylation	QYVSSTASLDNVYLG HHHHCCCCCCHHHHH	36.02	-
227	Phosphorylation	QGCKVDNSSLTGESE CCCEEECCCCCCCCC	23.43	25195567
228	Phosphorylation	GCKVDNSSLTGESEP CCEEECCCCCCCCCC	35.88	25195567
239	Phosphorylation	ESEPQARSTEFTHEN CCCCCCCCCCCCCCC	34.99	-
286	Phosphorylation	GRIASLASGVGSEKT HHHHHHHCCCCCCCC	39.03	-
389	Phosphorylation	SIICSDKTGTLTQNR EEEEECCCCCCCCCC	40.15	22324799
391	Phosphorylation	ICSDKTGTLTQNRMT EEECCCCCCCCCCEE	31.68	22324799
393	Phosphorylation	SDKTGTLTQNRMTVA ECCCCCCCCCCEEEE	24.52	29899451
463	Phosphorylation	RVVVGDASETALLKF EEECCCCCHHHHHHH	39.97	-
471	Phosphorylation	ETALLKFSEVILGDV HHHHHHHHHHHHHCH	29.39	29899451
487	Ubiquitination	DIRKRNHKVAEIPFN CHHHCCCEEEECCCC	46.84	-
495	Phosphorylation	VAEIPFNSTNKFQLS EEECCCCCCCCEEEE	33.46	22324799
496	Phosphorylation	AEIPFNSTNKFQLSI EECCCCCCCCEEEEE	43.46	24925903
601	Phosphorylation	LCFVGLLSMIDPPRS EEEEHHHHCCCCCCC	20.80	-
619	Phosphorylation	DAVSKCRSAGIKVIM HHHHHHHHCCCEEEE	40.07	29899451
628	O-linked_Glycosylation	GIKVIMVTGDHPITA CCEEEEECCCCCCCH	21.36	55445447
628	Phosphorylation	GIKVIMVTGDHPITA CCEEEEECCCCCCCH	21.36	28638064
634	Phosphorylation	VTGDHPITAKAIAKS ECCCCCCCHHHHHHH	26.93	-
636	Ubiquitination	GDHPITAKAIAKSVG CCCCCCHHHHHHHCC	31.51	-
709	Ubiquitination	ARTSPQQKLIIVEGC EECCCCCCEEEEECC	36.08	-
716	Glutathionylation	KLIIVEGCQRQDAVV CEEEEECCCCCCCEE	1.58	24333276
733	Phosphorylation	TGDGVNDSPALKKAD ECCCCCCCHHHHHCC	13.58	21183079
737	Acetylation	VNDSPALKKADIGIA CCCCHHHHHCCCEEE	48.28	-
750	Phosphorylation	IAMGIAGSDAAKNAA EEEECCCHHHHHCHH	18.30	25159016
784	Ubiquitination	RLIFDNLKKTIAYTL EEEECCHHHHHHHHH	54.87	-
840	Phosphorylation	LAYEKAESDIMNRKP HHHHHHHHHHHCCCC	36.98	-
954	Phosphorylation	IRKTRRNSIFQQGLF HHHHCCCCHHHCCCC	23.98	-
972	Phosphorylation	VIWVGIISQIIVALV CHHHHHHHHHHHHHH	17.26	25777480
981	Phosphorylation	IIVALVLSYGLGSVT HHHHHHHHCCCCHHH	15.07	25777480
982	Phosphorylation	IVALVLSYGLGSVTA HHHHHHHCCCCHHHH	16.53	25777480
986	Phosphorylation	VLSYGLGSVTALSFT HHHCCCCHHHHHHHH	22.72	25777480
988	Phosphorylation	SYGLGSVTALSFTML HCCCCHHHHHHHHHH	24.47	25777480
991	Phosphorylation	LGSVTALSFTMLRAQ CCHHHHHHHHHHHHH	19.06	25777480
993	Phosphorylation	SVTALSFTMLRAQYW HHHHHHHHHHHHHHH	16.36	25777480
1024	Phosphorylation	RKLFIRLYPGSWWDK HHHHHHHCCCCCCCC	8.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
954	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AT12A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AT12A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AT12A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.