TTLL4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TTLL4_MOUSE
• UniProt AC: Q80UG8
• Protein Name: Tubulin polyglutamylase TTLL4
• Gene Name: Ttll4
• Organism: Mus musculus (Mouse).
• Sequence Length: 1193
• Subcellular Localization: Cell projection, cilium . Cytoplasm, cytoskeleton, cilium basal body . Located in cilia. In some cells, also found in basal bodies.
• Protein Description: Glutamylase which preferentially modifies beta-tubulin and non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS. [PubMed: 17499049]
• Protein Sequence: MASAGTEHYSIGLRRGNSFKQRHPSGTVSASPSEKPSEVKVWSQAHQQVKPIWKLEKKHVGTLSAGLGTSFLGVPSQPAYFLCPSTLCSSGTTAVIAGHSNPCYLQSLPNLFSNTLLYRRTNVRQKPYQQLESFCLRSSPSEKRSFSLPQKGLPVSVTANKATSSTVFPMAQPMATSPTDPYLSLAAAGENPSRKSLASAISGKIASPLSYKPMLNNNSFMRPNSTKVPLSQATDGLKPVSSPKIQPVSWHHSGGTGDCVPQPGDHKVPQNIATVLDDVTAPITPSIPSTLNISTASVTSSQCSQSNFRMEAHPCGLDENPDSQSATKEVHFTEAVRKLAEKGLEKMPRQGYQFEQACFVNPSFQWGLLNRSRRWKPLMGQRFPQEDIGLDSAILPGTSDTLGLDSTVFCTKRISIHLLASHVHGLNPSPACGSAVDPQVLGEDRAPVPPSSLQPLGVAEVATRLSSVHLDQPGKEPEEAKDLNSCTKGGGSATDLQPNQVEPEDTEDELGDGLEDSCSHDENEEEEGDSECSSLSVVSPSESVALISRNCVDLMSKSLPNHEKVVRPALIYSLFPNVTPTIYFGTRDERVEKLPWEQRRLLRWKMSTVTPNIVKQTIGRSHFKISKRNDDWLGCWGHHMKSPGFRSIREHQKLNHFPGSFQIGRKDRLWRNLSRMQSRFGKKEFSFFPQSFILPQDSKLLRKAWESSSRQKWIVKPPASARGIGIQVIHKWSQLPKRRPLLVQRYLHKPYLISGSKFDLRIYVYVTSYDPLRIYLFSDGLVRFASCKYSPSMKSLSNKFMHLTNYSVNKKNTEYQANADETACQGHKWALKALWNYLSQKGINSDAIWEKIKDVVVKTIISSEPYVTNLLKLYVRRPYSCHELFGFDIMLDENLKPWVLEVNISPSLHSNSPLDISIKGQMIRDLLNLAGFVLPNMEDIISSSSSPSSSSGSSTSLPSSPRDKCQMTPEHFTAQKMKKAYYLTQKIPDQDFYASVLDVLTPDDVRVLVEMEDEFSRRGQFERIFPSRISSRYLRFFEQPRYFNILTTQWEQKYHGNKLKGVDLLRNWCYKGFHTGIVSDSAPLWSLPTSLMTTSKGDGTPNSASKSRKKSASEGTTLSSEDRSTPKSKKSQAGLSPISRKTLSSRSNENTSKQSKRSTPGLPVLKYSGQSSRLSAASASQSVTDSRLTAVSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
241	Phosphorylation	TDGLKPVSSPKIQPV CCCCCCCCCCCCCCC	49.83	28066266
242	Phosphorylation	DGLKPVSSPKIQPVS CCCCCCCCCCCCCCC	30.37	28066266
466	Phosphorylation	AEVATRLSSVHLDQP HHHHHHHHHCCCCCC	27.33	28059163
467	Phosphorylation	EVATRLSSVHLDQPG HHHHHHHHCCCCCCC	20.39	28059163
686	Phosphorylation	RFGKKEFSFFPQSFI HHCCCCCCCCCHHHC	27.37	-
789	Phosphorylation	VRFASCKYSPSMKSL EEECCCCCCCCHHHH	30.09	22871156
797	Phosphorylation	SPSMKSLSNKFMHLT CCCHHHHHHHHHHHH	45.10	22871156
806	Phosphorylation	KFMHLTNYSVNKKNT HHHHHHCCCCCCCCC	14.57	22871156
845	Phosphorylation	LSQKGINSDAIWEKI HHHCCCCCHHHHHHH	26.88	27742792
979	Acetylation	FTAQKMKKAYYLTQK HHHHHHHHHHHHHCC	37.82	15620135
986	Acetylation	KAYYLTQKIPDQDFY HHHHHHCCCCCCHHH	51.47	15620143
1111	Phosphorylation	ASKSRKKSASEGTTL CCHHHCCCCCCCCCC	39.81	25521595
1124	Phosphorylation	TLSSEDRSTPKSKKS CCCCCCCCCCCCHHH	62.47	20139300
1128	Phosphorylation	EDRSTPKSKKSQAGL CCCCCCCCHHHCCCC	46.66	20139300
1131	Phosphorylation	STPKSKKSQAGLSPI CCCCCHHHCCCCCCC	29.06	20139300
1136	Phosphorylation	KKSQAGLSPISRKTL HHHCCCCCCCCHHHH	21.19	23984901
1139	Phosphorylation	QAGLSPISRKTLSSR CCCCCCCCHHHHCCC	30.98	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TTLL4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TTLL4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TTLL4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TTLL4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.