dbPTM

SRSF9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SRSF9_MOUSE
UniProt AC	Q9D0B0
Protein Name	Serine/arginine-rich splicing factor 9
Gene Name	Srsf9
Organism	Mus musculus (Mouse).
Sequence Length	222
Subcellular Localization	Nucleus.
Protein Description	Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10 (By similarity)..
Protein Sequence	MSSGWADERGGEGDGRIYVGNLPSDVREKDLEDLFYKYGRIREIELKNRHGLVPFAFVRFEDPRDAEDAIYGRNGYDYGQCRLRVEFPRTYGGRGGWPRGARNGPPTRRSDFRVLVSGLPPSGSWQDLKDHMREAGDVCYADVQKDGMGMVEYLRKEDMEYALRKLDDTKFRSHEGETSYIRVYPERSTSYGYSRSRSGSRGRDSPYQSRGSPHYFSPFRPY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSGWADER ------CCCCCCCCC	37.24	26824392
3	Phosphorylation	-----MSSGWADERG -----CCCCCCCCCC	36.74	20469934
37	Ubiquitination	DLEDLFYKYGRIREI HHHHHHHHHCCEEEE	33.62	-
71	Phosphorylation	RDAEDAIYGRNGYDY CCHHHHHCCCCCCCC	16.26	22817900
94	Methylation	FPRTYGGRGGWPRGA CCCCCCCCCCCCCCC	35.77	24394753
99	Methylation	GGRGGWPRGARNGPP CCCCCCCCCCCCCCC	44.91	30761013
124	Phosphorylation	SGLPPSGSWQDLKDH ECCCCCCCHHHHHHH	26.38	-
129	Ubiquitination	SGSWQDLKDHMREAG CCCHHHHHHHHHHHC	54.61	27667366
161	Phosphorylation	LRKEDMEYALRKLDD HCHHHHHHHHHHCCC	12.33	22817900
180	Phosphorylation	SHEGETSYIRVYPER CCCCCCEEEEEECCC	10.52	22817900
188	Phosphorylation	IRVYPERSTSYGYSR EEEECCCCCCCCCCC	21.75	25159016
189	Phosphorylation	RVYPERSTSYGYSRS EEECCCCCCCCCCCC	31.99	24453211
190	Phosphorylation	VYPERSTSYGYSRSR EECCCCCCCCCCCCC	20.15	23684622
191	Phosphorylation	YPERSTSYGYSRSRS ECCCCCCCCCCCCCC	21.85	25159016
193	Phosphorylation	ERSTSYGYSRSRSGS CCCCCCCCCCCCCCC	7.83	20139300
194	Phosphorylation	RSTSYGYSRSRSGSR CCCCCCCCCCCCCCC	21.29	23684622
196	Phosphorylation	TSYGYSRSRSGSRGR CCCCCCCCCCCCCCC	25.51	29550500
198	Phosphorylation	YGYSRSRSGSRGRDS CCCCCCCCCCCCCCC	42.22	21659605
200	Phosphorylation	YSRSRSGSRGRDSPY CCCCCCCCCCCCCCC	32.57	21659605
205	Phosphorylation	SGSRGRDSPYQSRGS CCCCCCCCCCCCCCC	24.93	25521595
207	Phosphorylation	SRGRDSPYQSRGSPH CCCCCCCCCCCCCCC	24.07	25159016
209	Phosphorylation	GRDSPYQSRGSPHYF CCCCCCCCCCCCCCC	32.53	25159016
212	Phosphorylation	SPYQSRGSPHYFSPF CCCCCCCCCCCCCCC	13.85	27087446
215	Phosphorylation	QSRGSPHYFSPFRPY CCCCCCCCCCCCCCC	14.77	27742792
217	Phosphorylation	RGSPHYFSPFRPY-- CCCCCCCCCCCCC--	18.90	27087446
222	Phosphorylation	YFSPFRPY------- CCCCCCCC-------	27.25	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SRSF9_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SRSF9_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SRSF9_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SRSF9_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SRSF9_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-205; SER-212 ANDSER-217, AND MASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212 AND SER-217, ANDMASS SPECTROMETRY.	17242355 [Abstract]
"A differential phosphoproteomic analysis of retinoic acid-treated P19cells."; Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.; J. Proteome Res. 6:3174-3186(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212, AND MASSSPECTROMETRY.	17622165 [Abstract]