PLCG2_MOUSE - dbPTM
PLCG2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PLCG2_MOUSE
UniProt AC Q8CIH5
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Gene Name Plcg2
Organism Mus musculus (Mouse).
Sequence Length 1265
Subcellular Localization
Protein Description The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity)..
Protein Sequence MTTMVNVDTLPEYEKSQIKRALELGTVMTVFNARKSTPERRTVQMIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRHKAECCFTILYGTQFVLSTLSLATDSKEDAVKWLSGLKILHQEAMSASTPTMIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSGIKFLKDKLVEIGAQKDELSFEQFHLFYKKLMFDQQKSILDEFKKDSSVFILGNTDRPDASAVYLQDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIELDCWDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCSVEQQRHMAKVFKEVLGDMLLTKPTEASADQLPSPSQLREKIIIKHKKLGPKGDVDVNVEDKKDEHKPQGELYMWDSIDQKWTRHYCAIADAKLSFGDDIEQAVEEEPVQDTPPTELHFGEKWFHKKVESRTSAEKLLQEYCAETGAKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMENGVMKYYLTDNLTFNSIYALIQHYREAHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGTNSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELTFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISAGDAEEMEKQIIEDNPLGSLCKGILDLNTYNVVKAPQGKNQKAFVFILEPKKQGDPPVEFATDRVEELFEWFQSIREITWKMDTKENNMKYWERNQSIAIELSDLVVYCKPTSKTKDHLENPDFREIRSFVETKADSIVRQKPVDLLRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQMNHALFSLNGRTGYVLQPESMRSEKYDPMPLESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDSNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRGANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSNSRFYS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationNVDTLPEYEKSQIKR
CCCCCCHHHHHHHHH		27.0725367039
16PhosphorylationTLPEYEKSQIKRALE
CCCHHHHHHHHHHHH		25.7926643407
26PhosphorylationKRALELGTVMTVFNA
HHHHHHHCHHHHHHC		21.5226643407
29PhosphorylationLELGTVMTVFNARKS
HHHHCHHHHHHCCCC		20.0126643407
49PhosphorylationTVQMIMETRQVAWSK
HHHHHHHHHHHHHHH		14.7122817900
160PhosphorylationVDQTRRNSISLRELK
CCHHHCCCCCHHHHH		16.2524704852
162PhosphorylationQTRRNSISLRELKTI
HHHCCCCCHHHHHHH		22.6129895711
242PhosphorylationRPDASAVYLQDFQRF
CCCCCEEHHHHHHHH		9.81-
371PhosphorylationPDGKPIIYHGWTRTT
CCCCEEEEECCCCCE		8.5922817900
375PhosphorylationPIIYHGWTRTTKIKF
EEEEECCCCCEEECH		23.80-
482PhosphorylationHKPQGELYMWDSIDQ
CCCCCEEEEEECCCC		7.5825367039
495PhosphorylationDQKWTRHYCAIADAK
CCCCCHHEEHHHCCC		4.74-
677PhosphorylationLIRKREGTNSYAITF
EEEEECCCCEEEEEE		19.0825367039
679PhosphorylationRKREGTNSYAITFRA
EEECCCCEEEEEEEE		18.7725367039
680PhosphorylationKREGTNSYAITFRAR
EECCCCEEEEEEEEC		12.2322817900
751PhosphorylationNMERDINSLYDVSRM
CCCCCHHHHHHHHHH		28.7425159016
753PhosphorylationERDINSLYDVSRMYV
CCCHHHHHHHHHHCC		17.7015509800
759PhosphorylationLYDVSRMYVDPSEIN
HHHHHHHCCCHHHCC		10.6915509800
768PhosphorylationDPSEINPSMPQRTVK
CHHHCCCCCCHHHHH		38.3128059163
811PhosphorylationGGWWKGDYGTRIQQY
CCCCCCCCHHHHHHH		29.12-
818PhosphorylationYGTRIQQYFPSNYVE
CHHHHHHHCCCCCCC		10.90-
823PhosphorylationQQYFPSNYVEDISAG
HHHCCCCCCCCCCCC		15.00-
957PhosphorylationPDFREIRSFVETKAD
CCHHHHHHHHHHHHH		39.0329176673
1045PhosphorylationLQPESMRSEKYDPMP
CCCHHHCCCCCCCCC		29.7825159016
1048PhosphorylationESMRSEKYDPMPLES
HHHCCCCCCCCCHHH		22.6425159016
1197PhosphorylationLESEEELYSSCRQLR
CCCHHHHHHHHHHHH		11.21-
1217PhosphorylationLNNQLFLYDTHQNLR
HHHHEEEHHHHCCCC		16.0915509800
1219PhosphorylationNQLFLYDTHQNLRGA
HHEEEHHHHCCCCCC		16.2930387612
1245PhosphorylationNENQLQLYQEKCNRR
CHHHHHHHHHHHHHH		11.1525159016
1259PhosphorylationRLREKRVSNSRFYS-
HHHHHHHCCCCCCC-		32.8722817900
1261PhosphorylationREKRVSNSRFYS---
HHHHHCCCCCCC---		19.0919854140
1264PhosphorylationRVSNSRFYS------
HHCCCCCCC------		16.6225367039
1265PhosphorylationVSNSRFYS-------
HCCCCCCC-------		30.9125367039
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
753YPhosphorylationKinaseBTKP35991
Uniprot
759YPhosphorylationKinaseBTKP35991
Uniprot
1197YPhosphorylationKinaseBTKP35991
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PLCG2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PLCG2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CSF1R_MOUSECsf1rphysical
9312046
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PLCG2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling.";
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.;
J. Immunol. 179:5864-5876(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-753; TYR-1217 ANDTYR-1245, AND MASS SPECTROMETRY.

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