STIL_MOUSE - dbPTM
STIL_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STIL_MOUSE
UniProt AC Q60988
Protein Name SCL-interrupting locus protein homolog
Gene Name Stil
Organism Mus musculus (Mouse).
Sequence Length 1262
Subcellular Localization Cytoplasm, cytosol . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole .
Protein Description Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly (By similarity)..
Protein Sequence MNTRFPSSKMVPFHFPPSKLALWNPMPIGECIYLHLSYYRKPKLMVTEKAIRLAYRHAKQNKKNVPCFLLGSLTVDEDEEGVTLTIDRFDPGREIPECLERTPTASLPGDFLIPCRVHIQGLGSRDVIVHNADDFSSALKALQYHVCSKDFLDCGKLLCLRAQITPRESLDGVDFNLQWTAVTLANSFKCVPVKPIPIIPTALARNLSSNLNISQVQGTYKHGYITMDETRKLLLLLQSDPKVSSLPLVGIWLAGIIHVYSPQVWACCLRYMFSSSIQERVFSESGNFIIVLYSLTHKEPEFYECLPCESRTPDLQFQLLTNKETLHLFNNVEPSGKNPIHFELSAESQDAEAEAEVLSKISKTLPVKRSSQKVSPGKIPINKHDTDLEDEDFSPRPIPSPHPVSQKISKVQPSVPELSLVLDNNFTESSNQSNPLEMMTVENPLLIKPSQPELCDAKHSSEATTGEPFRRGPTNQLSQDTALRQSRGKQSSTCKKESLQFRNTNAKPSLSVPSPDVAEKLQAVSAGSMQKEDYPVRPSTLDSRQPSLAPQAQPHNLVFSTHNSTRPMELQVPTPSLPSYYPTNVCSCCQHHGHIQYSTINSWQGNTVGSIQDLRSESLPKHAFFHSSGCPSLCPNAIYSSSSPVSMKQGGMGAYSPHSNGEPSPVAGPSHVDSCVPHPCAMCMHTPNTAPDNGMMGLSPDAYRFVTEQDRQLRLLQAQIQRLLEAQSLDPGSHKTVATMEDTVKAARQMELVSMEAQSSPGLHMRKSVSIAVSTGASLFWNAAGDDQEPDSQPKQDDTKISSEDMNFSVDINNEATSLPGSASSLKAVDIPSFEESNLAVEEVNQPLPESNSSSEQSKEPGVPVFFPNALLAESVSMCLQTAPTEGASNSTELPQGTKDEPYRPSDNQKIYQDLLGQVNHLLSNASQETEEPPTKAVVTNHECAKTQNTHHARKKRHNSGLVDKDCVLSATIKQLRSLGVKIDSPTKVKKNEQKVDHASVLACISPEAVISGLNYMSFGNVGMSSLSPTGVDLSMEANAIALKYLSENQLSQLSLARSKQNNGDSSVGLLHINSDRSTVGLSLVSPSNMSFATKKYMKRYGLLQSSDNSEDEEEPPSHADSESDHVLNRNPACRPVQCGHEKEPSWNACEIAQCSDCGSADTRTDVPVLRNITNQAVQPRATEHLNEDSAISLRNLKPNPAMNLRTGKAEFTHHPEKENERDIAVFPGTLPSPETLKQMNSMDSVGTFLDVKRLRQLPKLF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
137PhosphorylationHNADDFSSALKALQY
ECCCCHHHHHHHHHH		37.3021183079
368AcetylationISKTLPVKRSSQKVS
HHHCCCCCCCCCCCC		44.6215613323
375PhosphorylationKRSSQKVSPGKIPIN
CCCCCCCCCCCCCCC		34.6624719451
383AcetylationPGKIPINKHDTDLED
CCCCCCCCCCCCCCC		43.5115613333
474PhosphorylationEPFRRGPTNQLSQDT
CCCCCCCCCCCCHHH		38.1222817900
478PhosphorylationRGPTNQLSQDTALRQ
CCCCCCCCHHHHHHH		19.0822817900
486PhosphorylationQDTALRQSRGKQSST
HHHHHHHHCCCCCHH		36.2421183079
511PhosphorylationTNAKPSLSVPSPDVA
CCCCCCCCCCCHHHH		36.0028066266
514PhosphorylationKPSLSVPSPDVAEKL
CCCCCCCCHHHHHHH		31.4128066266
610PhosphorylationWQGNTVGSIQDLRSE
CCCCCCCCHHHHHCC		16.8522802335
733PhosphorylationAQSLDPGSHKTVATM
HHCCCCCCCCEEECH		27.48-
760PhosphorylationVSMEAQSSPGLHMRK
EEEECCCCCCCCCCC		15.77-
960PhosphorylationARKKRHNSGLVDKDC
HHHHHHCCCCCCHHH		27.6425619855
985PhosphorylationSLGVKIDSPTKVKKN
HCCCCCCCCCCCCCC		37.6330482847
1059PhosphorylationSQLSLARSKQNNGDS
HHHHHHHHHCCCCCC		32.74-
1079PhosphorylationHINSDRSTVGLSLVS
EECCCCCEEEEEEEC		21.3421183079
1083PhosphorylationDRSTVGLSLVSPSNM
CCCEEEEEEECCCCC		22.3121183079
1086PhosphorylationTVGLSLVSPSNMSFA
EEEEEEECCCCCCHH		28.0921183079
1091PhosphorylationLVSPSNMSFATKKYM
EECCCCCCHHHHHHH		18.9122817900
1101PhosphorylationTKKYMKRYGLLQSSD
HHHHHHHHCCCCCCC		13.4525293948
1106PhosphorylationKRYGLLQSSDNSEDE
HHHCCCCCCCCCCCC		39.3625293948
1107PhosphorylationRYGLLQSSDNSEDEE
HHCCCCCCCCCCCCC		28.0522817900
1110PhosphorylationLLQSSDNSEDEEEPP
CCCCCCCCCCCCCCC		51.9522817900
1190PhosphorylationTEHLNEDSAISLRNL
CCCCCCCCCCCCCCC		22.7126370283
1193PhosphorylationLNEDSAISLRNLKPN
CCCCCCCCCCCCCCC		22.4626370283
1207PhosphorylationNPAMNLRTGKAEFTH
CCCCCCCCCCEEECC		46.3222942356
1230PhosphorylationDIAVFPGTLPSPETL
CEEECCCCCCCHHHH		35.4226745281
1233PhosphorylationVFPGTLPSPETLKQM
ECCCCCCCHHHHHHH		38.1826745281
1236PhosphorylationGTLPSPETLKQMNSM
CCCCCHHHHHHHCCC		42.5126745281
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of STIL_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STIL_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STIL_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of STIL_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STIL_MOUSE

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Related Literatures of Post-Translational Modification

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