| UniProt ID | UBA5_MOUSE | |
|---|---|---|
| UniProt AC | Q8VE47 | |
| Protein Name | Ubiquitin-like modifier-activating enzyme 5 | |
| Gene Name | Uba5 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 403 | |
| Subcellular Localization | Cytoplasm . Nucleus . Golgi apparatus . Localizes mainly in the cytoplasm, while it localizes to the nucleus in presence of SUMO2. | |
| Protein Description | E1-like enzyme which activates UFM1 and SUMO2.. | |
| Protein Sequence | MADSVERLRQRVEELEQELARERTRRSGGDGHCGRTRIQEMSDEVLDSNPYSRLMALKRMGIVSDYKKIRTYAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPYQAGLSKVHAAEHTLRNINPDVLFEVHNYNITTVEHFEHFMNRISNGGLEEGQPVDLVLSCVDNFEARMAINTACNELGQTWMESGVSENAVSGHIQLMIPGESACFACAPPLVVASNIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLKFGTVSFYLGYNAMQDFFPTMFMKPNPQCDDKNCRKQQEEYKKRAAALPTQEAEPQEEAEVVHEDNEWGIELVSEVSEEELKNSSGPVPTLPEGITVAYTVPKKTEDSASEVTVEDSGESLEDLMARMKNM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MADSVERLRQR ----CCHHHHHHHHH | 19.15 | 26824392 | |
| 71 | Phosphorylation | SDYKKIRTYAVAIVG CCHHHHHEEEEEEEC | 21.21 | 20469934 | |
| 72 | Phosphorylation | DYKKIRTYAVAIVGV CHHHHHEEEEEEECC | 6.82 | 20469934 | |
| 84 | Phosphorylation | VGVGGVGSVTAEMLT ECCCCCHHHHHHHHH | 17.56 | 20469934 | |
| 86 | Phosphorylation | VGGVGSVTAEMLTRC CCCCHHHHHHHHHHC | 20.71 | 20469934 | |
| 91 | Phosphorylation | SVTAEMLTRCGIGKL HHHHHHHHHCCCCCE | 23.70 | 20469934 | |
| 248 | S-palmitoylation | TLKREGVCAASLPTT HCCCCCCCCCCCCCC | 3.73 | 28526873 | |
| 356 | Phosphorylation | SEEELKNSSGPVPTL CHHHHHCCCCCCCCC | 34.78 | 26643407 | |
| 357 | Phosphorylation | EEELKNSSGPVPTLP HHHHHCCCCCCCCCC | 57.41 | 25521595 | |
| 372 | Phosphorylation | EGITVAYTVPKKTED CCEEEEEECCCCCCC | 22.16 | 29514104 | |
| 377 | Phosphorylation | AYTVPKKTEDSASEV EEECCCCCCCCCCEE | 51.67 | 30635358 | |
| 380 | Phosphorylation | VPKKTEDSASEVTVE CCCCCCCCCCEEEEE | 27.71 | 21082442 | |
| 382 | Phosphorylation | KKTEDSASEVTVEDS CCCCCCCCEEEEECC | 36.23 | 25521595 | |
| 385 | Phosphorylation | EDSASEVTVEDSGES CCCCCEEEEECCCCC | 17.71 | 30635358 | |
| 389 | Phosphorylation | SEVTVEDSGESLEDL CEEEEECCCCCHHHH | 30.84 | 21183079 | |
| 392 | Phosphorylation | TVEDSGESLEDLMAR EEECCCCCHHHHHHH | 40.35 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UBA5_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBA5_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBA5_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of UBA5_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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