M4K1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: M4K1_MOUSE
• UniProt AC: P70218
• Protein Name: Mitogen-activated protein kinase kinase kinase kinase 1
• Gene Name: Map4k1
• Organism: Mus musculus (Mouse).
• Sequence Length: 827
• Protein Description: Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate..
• Protein Sequence: MALVDPDIFNKDPREHYDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKMEPDDDVATLQKEILMLKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKMLSHQLVSQPGLNRGLILDLLDKMKNPGKGLPVDIEDEEPEPPPAIPRRIRSTYRASSLGIPDADCCRRQMEFQRPRCVDCRPQAETVRLYPPAHFGSTSPRSQLSDSDDDYDDVDIPAPSENIPPPLPPKPKFRSPSDDGSGGIRDDGQLSPGVLVRCASGPPPRTPRPGPPPATCSPHLTARSDPSLWNPAAPEPGQPPLVPPRKEKMRGKMENEKRREKYPLLVKLFNGCPLQIHSTAAWTHPSTKDQNLLLGAEEGIFILNRNDQEATLEMIFPGRTTWLYCINNLLMSLSGKTPYLYSHSILGLLERKDGRTGSPIAHISPHRLLARKNMVSSKIQDTKGCRACCVAESASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLPVFTLLTTPGSELPAVCIGVSPGQAAKSVLFHTVRFGALSCWLDDSSTEHKGPVQVIQVKEDMVMVLMDGSLKLVTPEGAPAPGLRTPEIPMTEAVEAVAMVEDRLEAFWKHGVQVWAPGLKQPLQELRDPTLTFRLLCSPRPVVVETRPTDDPTAPSNLYIQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
165	Phosphorylation	ISAQIGATLARRLSF CHHHHHHHHHHHHHC	18.75	-
171	Phosphorylation	ATLARRLSFIGTPYW HHHHHHHHCCCCCCC	17.01	17895239
175	Phosphorylation	RRLSFIGTPYWMAPE HHHHCCCCCCCCCHH	14.37	-
324	Phosphorylation	IRSTYRASSLGIPDA HHHHHHHHHCCCCCH	19.66	25266776
325	Phosphorylation	RSTYRASSLGIPDAD HHHHHHHHCCCCCHH	29.63	25266776
354	Phosphorylation	DCRPQAETVRLYPPA CCCCCCEEEEECCCC	17.59	-
365	Phosphorylation	YPPAHFGSTSPRSQL CCCCCCCCCCCHHHC	25.43	28833060
366	Phosphorylation	PPAHFGSTSPRSQLS CCCCCCCCCCHHHCC	43.03	28833060
367	Phosphorylation	PAHFGSTSPRSQLSD CCCCCCCCCHHHCCC	21.73	28833060
370	Phosphorylation	FGSTSPRSQLSDSDD CCCCCCHHHCCCCCC	38.57	24704852
373	Phosphorylation	TSPRSQLSDSDDDYD CCCHHHCCCCCCCCC	27.68	24704852
375	Phosphorylation	PRSQLSDSDDDYDDV CHHHCCCCCCCCCCC	39.29	24704852
379	Phosphorylation	LSDSDDDYDDVDIPA CCCCCCCCCCCCCCC	22.49	24704852
388	Phosphorylation	DVDIPAPSENIPPPL CCCCCCCCCCCCCCC	45.44	19854140
403	Phosphorylation	PPKPKFRSPSDDGSG CCCCCCCCCCCCCCC	31.71	24704852
405	Phosphorylation	KPKFRSPSDDGSGGI CCCCCCCCCCCCCCC	49.97	27180971
409	Phosphorylation	RSPSDDGSGGIRDDG CCCCCCCCCCCCCCC	40.62	25266776
419	Phosphorylation	IRDDGQLSPGVLVRC CCCCCCCCCCEEEEE	16.24	22942356
428	Phosphorylation	GVLVRCASGPPPRTP CEEEEECCCCCCCCC	56.30	25266776
443	Phosphorylation	RPGPPPATCSPHLTA CCCCCCCCCCCCCCC	21.20	30482847
445	Phosphorylation	GPPPATCSPHLTARS CCCCCCCCCCCCCCC	15.82	25266776
449	Phosphorylation	ATCSPHLTARSDPSL CCCCCCCCCCCCHHH	19.59	21082442
452	Phosphorylation	SPHLTARSDPSLWNP CCCCCCCCCHHHCCC	51.95	27180971
455	Phosphorylation	LTARSDPSLWNPAAP CCCCCCHHHCCCCCC	51.51	28066266
565	Phosphorylation	LMSLSGKTPYLYSHS HHHHCCCCCHHCHHH	22.23	25367039
567	Phosphorylation	SLSGKTPYLYSHSIL HHCCCCCHHCHHHHH	24.41	25367039
569	Phosphorylation	SGKTPYLYSHSILGL CCCCCHHCHHHHHHH	9.86	25367039
584	Phosphorylation	LERKDGRTGSPIAHI HHCCCCCCCCCCCCC	47.76	28066266
586	Phosphorylation	RKDGRTGSPIAHISP CCCCCCCCCCCCCCH	16.72	28066266
592	Phosphorylation	GSPIAHISPHRLLAR CCCCCCCCHHHHHHH	12.56	28066266
605	Phosphorylation	ARKNMVSSKIQDTKG HHHCCCCHHCCCCCC	23.51	22322096

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
165	T	Phosphorylation	Kinase	MAP4K1	P70218	GPS
171	S	Phosphorylation	Kinase	PRKACA	P05132	GPS
171	S	Phosphorylation	Kinase	PRKD1	Q62101	GPS
379	Y	Phosphorylation	Kinase	SYK	P48025	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of M4K1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of M4K1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of M4K1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.