POSTN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: POSTN_MOUSE
• UniProt AC: Q62009
• Protein Name: Periostin
• Gene Name: Postn
• Organism: Mus musculus (Mouse).
• Sequence Length: 838
• Subcellular Localization: Golgi apparatus . Secreted . Secreted, extracellular space, extracellular matrix . Colocalizes with BMP1 in the Golgi (PubMed:20181949).
• Protein Description: Induces cell attachment and spreading and plays a role in cell adhesion. [PubMed: 10404027 Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX]
• Protein Sequence: MVPLLPLYALLLLFLCDINPANANSYYDKVLAHSRIRGRDQGPNVCALQQILGTKKKYFSSCKNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDHVYGTLGIVGATTTQHYSDVSKLREEIEGKGSYTYFAPSNEAWENLDSDIRRGLENNVNVELLNALHSHMVNKRMLTKDLKHGMVIPSMYNNLGLFINHYPNGVVTVNCARVIHGNQIATNGVVHVIDRVLTQIGTSIQDFLEAEDDLSSFRAAAITSDLLESLGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSEAITGGAVFETMEGNTIEIGCEGDSISINGIKMVNKKDIVTKNGVIHLIDEVLIPDSAKQVIELAGKQQTTFTDLVAQLGLASSLKPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKVGLSDLYNGQILETIGGKQLRVFVYRTAICIENSCMVRGSKQGRNGAIHIFREIIQPAEKSLHDKLRQDKRFSIFLSLLEAADLKDLLTQPGDWTLFAPTNDAFKGMTSEERELLIGDKNALQNIILYHLTPGVYIGKGFEPGVTNILKTTQGSKIYLKGVNETLLVNELKSKESDIMTTNGVIHVVDKLLYPADIPVGNDQLLELLNKLIKYIQIKFVRGSTFKEIPMTVYTTKIITKVVEPKIKVIQGSLQPIIKTEGPAMTKIQIEGDPDFRLIKEGETVTEVIHGEPVIKKYTKIIDGVPVEITEKQTREERIITGPEIKYTRISTGGGETGETLQKFLQKEVSKVTKFIEGGDGHLFEDEEIKRLLQGDTPAKKIPANKRVQGPRRRSREGRSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
567	Phosphorylation	ALQNIILYHLTPGVY HHHHHHHEECCCCCE	5.60	28059163
570	Phosphorylation	NIILYHLTPGVYIGK HHHHEECCCCCEECC	12.51	28059163
601	N-linked_Glycosylation	KIYLKGVNETLLVNE EEEEECCCHHHHHHC	45.24	7663166
832	Phosphorylation	VQGPRRRSREGRSQ- CCCCCCCCCCCCCC-	32.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of POSTN_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of POSTN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of POSTN_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of POSTN_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.