FGD2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FGD2_MOUSE
• UniProt AC: Q8BY35
• Protein Name: FYVE, RhoGEF and PH domain-containing protein 2
• Gene Name: Fgd2
• Organism: Mus musculus (Mouse).
• Sequence Length: 655
• Subcellular Localization: Cytoplasm . Nucleus . Early endosome . Early endosome membrane . Cell projection, ruffle membrane . Cytoplasm, cytoskeleton . Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides.
• Protein Description: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate..
• Protein Sequence: MERACEKQDSVCNLVAVFENNRTPGEAPGSHSLEDQPHSPEHQLSLSPEPWEAPPVKEALKSEFRPVSRTYLSSLKNKLSSGAWRRSCQPGVSPGPETQEPEEKRVVRELLETEQAYVARLHLLDQVFFQELLREAGRSKAFPEDVVKLIFSNISSIYRFHAQFFLPELQRRVDDWAATPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWMDKSQPFQEVVTRIQCSEASSSLTLQHHMLEPVQRIPRYELLLKEYVQKLPAQAPDLEDAQRALDMIFSAAQHSNAAIAEMERLQGLWDVYQRLGLEDDIVDPSNTLLREGPVLKISFRRSDPMERYLVLFNNMLLYCVPRVLQVGAQFQVRTRIDVAGMKVRELTDAEFPHSFLVSGKQRTLELQARSRDEMVSWMQACQAAIDQVEKRSETFKAAVQGPQGDTQEPKPQVEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCAKCSDYRAELKYDSNRPNRVCLTCYTFLTGNVLPQGKEDKRRGILEKEASAAPEQSLVCSFLQLIGDKCSRSLPRSWCVIPRDDPLVLYVYAAPQDTKAHTSIPLLGYQVISGPQGDPRVFQLQQSGQQYTFKAESVELQGRWVTAIKRAASGRTPEGPDEEDVSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RACEKQDSVCNLVAV CHHHHHCCCHHEEEE	26.52	22817900
32	Phosphorylation	GEAPGSHSLEDQPHS CCCCCCCCCCCCCCC	34.84	25159016
39	Phosphorylation	SLEDQPHSPEHQLSL CCCCCCCCCCCCCCC	38.37	25159016
45	Phosphorylation	HSPEHQLSLSPEPWE CCCCCCCCCCCCCCC	21.89	26026062
47	Phosphorylation	PEHQLSLSPEPWEAP CCCCCCCCCCCCCCC	24.68	25159016
73	Phosphorylation	PVSRTYLSSLKNKLS CCCHHHHHHHHHHHC	24.18	29176673
74	Phosphorylation	VSRTYLSSLKNKLSS CCHHHHHHHHHHHCC	40.54	27180971
93	Phosphorylation	RSCQPGVSPGPETQE HCCCCCCCCCCCCCC	30.01	30635358
196	Phosphorylation	LAPFLKMYSEYVKNF HHHHHHHHHHHHHHH	9.21	28576409
199	Phosphorylation	FLKMYSEYVKNFERA HHHHHHHHHHHHHHH	15.70	28576409
212	Phosphorylation	RAAELLATWMDKSQP HHHHHHHHHHCCCCC	22.69	-
217	Phosphorylation	LATWMDKSQPFQEVV HHHHHCCCCCHHHHH	38.53	-
350	Phosphorylation	LFNNMLLYCVPRVLQ HHHCHHHHHHHHHHH	6.35	-
539	Phosphorylation	GILEKEASAAPEQSL CHHHHHHCCCHHHHH	26.51	24719451
559	Phosphorylation	QLIGDKCSRSLPRSW HHHCHHHCCCCCCCE	30.55	23737553
561	Phosphorylation	IGDKCSRSLPRSWCV HCHHHCCCCCCCEEE	26.82	23737553
644	Phosphorylation	KRAASGRTPEGPDEE HHHHCCCCCCCCCCC	29.26	19060867
654	Phosphorylation	GPDEEDVSD------ CCCCCCCCC------	50.34	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FGD2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FGD2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FGD2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FGD2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.