COPRS_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COPRS_MOUSE
• UniProt AC: Q9CQ13
• Protein Name: Coordinator of PRMT5 and differentiation stimulator
• Gene Name: Coprs
• Organism: Mus musculus (Mouse).
• Sequence Length: 173
• Subcellular Localization: Nucleus.
• Protein Description: Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression (By similarity). Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation..
• Protein Sequence: MDPQAATGRGPGERSSQEAPSAEAGFATADLSGRETETELAVDRLASGAQSIPADIPAHAEGPSSEEEGFAVEKEADGELYAWELSEGPSCPPMEQAADLFNEDWDLELKADQGNPYDADDIQGSISQEIKPWVCCAPQGDMIYDPSWHHPPPLIPHYSKMVFETGQFDDAED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDPQAATG -------CCHHHHCC		-
15	Phosphorylation	GRGPGERSSQEAPSA CCCCCCCCCCCCCCC		19060867
16	Phosphorylation	RGPGERSSQEAPSAE CCCCCCCCCCCCCCC		19060867
21	Phosphorylation	RSSQEAPSAEAGFAT CCCCCCCCCCCCCEE		25293948
51	Phosphorylation	RLASGAQSIPADIPA HHHHCCCCCCCCCCC		25338131
64	Phosphorylation	PAHAEGPSSEEEGFA CCCCCCCCCHHCCEE		27087446
65	Phosphorylation	AHAEGPSSEEEGFAV CCCCCCCCHHCCEEE		27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COPRS_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COPRS_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COPRS_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of COPRS_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.