| UniProt ID | 3BHS2_MOUSE | |
|---|---|---|
| UniProt AC | P26149 | |
| Protein Name | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 | |
| Gene Name | Hsd3b2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 373 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass membrane protein. Mitochondrion membrane Single-pass membrane protein. |
|
| Protein Description | 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.. | |
| Protein Sequence | MPGWSCLVTGAGGFLGQRIIQLLVQEEDLEEIRVLDKVFRPETRKEFFNLETSIKVTVLEGDILDTQYLRRACQGISVVIHTAAIIDVTGVIPRQTILDVNLKGTQNLLEACIQASVPAFIFSSSVDVAGPNSYKEIVLNGHEEECHESTWSDPYPYSKKMAEKAVLAANGSMLKNGGTLQTCALRPMCIYGERSPLISNIIIMALKHKGILRSFGKFNTANPVYVGNVAWAHILAARGLRDPKKSPNIQGEFYYISDDTPHQSFDDISYTLSKEWGFCLDSSWSLPVPLLYWLAFLLETVSFLLSPIYRYIPPFNRHLVTLSGSTFTFSYKKAQRDLGYEPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 45 | Ubiquitination | VFRPETRKEFFNLET HCCHHHHHHHCCCCC | 67.31 | 22790023 | |
| 52 | Phosphorylation | KEFFNLETSIKVTVL HHHCCCCCEEEEEEE | 38.63 | 21743459 | |
| 53 | Phosphorylation | EFFNLETSIKVTVLE HHCCCCCEEEEEEEE | 15.84 | 21743459 | |
| 77 | Phosphorylation | RRACQGISVVIHTAA HHHHCCCCEEEEEEE | 19.70 | 21454597 | |
| 82 | Phosphorylation | GISVVIHTAAIIDVT CCCEEEEEEEEEECC | 13.47 | 21454597 | |
| 89 | Phosphorylation | TAAIIDVTGVIPRQT EEEEEECCCCCCCCE | 23.22 | 21454597 | |
| 123 | Ubiquitination | SVPAFIFSSSVDVAG CCCEEEECCCCCCCC | 19.52 | 27667366 | |
| 152 | Phosphorylation | ECHESTWSDPYPYSK HHHCCCCCCCCCCCH | 28.88 | 23684622 | |
| 158 | Phosphorylation | WSDPYPYSKKMAEKA CCCCCCCCHHHHHHH | 22.69 | 23684622 | |
| 159 | Ubiquitination | SDPYPYSKKMAEKAV CCCCCCCHHHHHHHH | 40.50 | - | |
| 164 | Ubiquitination | YSKKMAEKAVLAANG CCHHHHHHHHHHCCC | 33.97 | 27667366 | |
| 172 | Phosphorylation | AVLAANGSMLKNGGT HHHHCCCCCCCCCCC | 22.28 | 25177544 | |
| 175 | Acetylation | AANGSMLKNGGTLQT HCCCCCCCCCCCCCC | 44.92 | 23201123 | |
| 309 | Ubiquitination | SFLLSPIYRYIPPFN HHHHHHHHHHCCCCC | 10.76 | 27667366 | |
| 311 | Ubiquitination | LLSPIYRYIPPFNRH HHHHHHHHCCCCCCE | 10.78 | 27667366 | |
| 350 | Ubiquitination | LVSWEEAKQKTSEWI CCCHHHHHHHHHHHH | 56.45 | 27667366 | |
| 352 | Ubiquitination | SWEEAKQKTSEWIGT CHHHHHHHHHHHHHH | 54.00 | 27667366 | |
| 372 | Phosphorylation | RETLDTKSQ------ HHHHCCCCC------ | 43.12 | 23140645 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of 3BHS2_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of 3BHS2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of 3BHS2_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of 3BHS2_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
