HPRT_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HPRT_MOUSE
• UniProt AC: P00493
• Protein Name: Hypoxanthine-guanine phosphoribosyltransferase
• Gene Name: Hprt1
• Organism: Mus musculus (Mouse).
• Sequence Length: 218
• Subcellular Localization: Cytoplasm.
• Protein Description: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity)..
• Protein Sequence: MPTRSPSVVISDDEPGYDLDLFCIPNHYAEDLEKVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVKQYSPKMVKVASLLVKRTSRSVGYRPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPTRSPSVVI -----CCCCCCCEEE	42.34	26745281
5	Phosphorylation	---MPTRSPSVVISD ---CCCCCCCEEECC	24.81	26745281
7	Phosphorylation	-MPTRSPSVVISDDE -CCCCCCCEEECCCC	30.20	26745281
11	Phosphorylation	RSPSVVISDDEPGYD CCCCEEECCCCCCCC	27.65	21189417
23	Glutathionylation	GYDLDLFCIPNHYAE CCCCEEEEECCHHHH	7.03	24333276
83	Acetylation	ADLLDYIKALNRNSD HHHHHHHHHHCCCCC	40.36	23954790
83	Ubiquitination	ADLLDYIKALNRNSD HHHHHHHHHHCCCCC	40.36	-
103	Malonylation	TVDFIRLKSYCNDQS EEEEEEEHHHHCCCC	29.54	26320211
103	Ubiquitination	TVDFIRLKSYCNDQS EEEEEEEHHHHCCCC	29.54	-
103	Acetylation	TVDFIRLKSYCNDQS EEEEEEEHHHHCCCC	29.54	23806337
104	Phosphorylation	VDFIRLKSYCNDQST EEEEEEHHHHCCCCC	39.24	30635358
106	S-nitrosylation	FIRLKSYCNDQSTGD EEEEHHHHCCCCCCC	6.13	22178444
106	Glutathionylation	FIRLKSYCNDQSTGD EEEEHHHHCCCCCCC	6.13	24333276
106	S-nitrosocysteine	FIRLKSYCNDQSTGD EEEEHHHHCCCCCCC	6.13	-
110	Phosphorylation	KSYCNDQSTGDIKVI HHHHCCCCCCCEEEE	36.90	25521595
111	Phosphorylation	SYCNDQSTGDIKVIG HHHCCCCCCCEEEEC	32.99	23984901
115	Ubiquitination	DQSTGDIKVIGGDDL CCCCCCEEEECCCCH	32.32	-
115	Malonylation	DQSTGDIKVIGGDDL CCCCCCEEEECCCCH	32.32	26320211
115	Acetylation	DQSTGDIKVIGGDDL CCCCCCEEEECCCCH	32.32	23236377
128	Ubiquitination	DLSTLTGKNVLIVED CHHHHCCCCEEEEEE	38.35	-
139	Phosphorylation	IVEDIIDTGKTMQTL EEEEEHHCCHHHHHH	30.12	29899451
142	Phosphorylation	DIIDTGKTMQTLLSL EEHHCCHHHHHHHHH	18.82	27180971
145	Phosphorylation	DTGKTMQTLLSLVKQ HCCHHHHHHHHHHHH	20.88	29472430
148	Phosphorylation	KTMQTLLSLVKQYSP HHHHHHHHHHHHHCH	33.94	27180971
151	Acetylation	QTLLSLVKQYSPKMV HHHHHHHHHHCHHHH	49.14	22826441
151	Ubiquitination	QTLLSLVKQYSPKMV HHHHHHHHHHCHHHH	49.14	27667366
153	Phosphorylation	LLSLVKQYSPKMVKV HHHHHHHHCHHHHHH	22.63	28059163
156	Ubiquitination	LVKQYSPKMVKVASL HHHHHCHHHHHHHHH	50.84	-
159	Ubiquitination	QYSPKMVKVASLLVK HHCHHHHHHHHHHHH	28.69	-
166	Acetylation	KVASLLVKRTSRSVG HHHHHHHHHHCCCCC	50.34	22826441
166	Ubiquitination	KVASLLVKRTSRSVG HHHHHHHHHHCCCCC	50.34	27667366
206	Glutathionylation	FRDLNHVCVISETGK HHCCCCEEEEECCCC	1.42	24333276

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HPRT_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HPRT_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HPRT_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HPRT_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.