CRCM1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRCM1_MOUSE
• UniProt AC: Q8BWG9
• Protein Name: Calcium release-activated calcium channel protein 1
• Gene Name: Orai1
• Organism: Mus musculus (Mouse).
• Sequence Length: 304
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, autophagosome . Colocalizes with UBQLN1 in the autophagosome. Colocalizes with STIM1 at the cell membrane.
• Protein Description: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT..
• Protein Sequence: MHPEPAPPPSHSNPELPVSGGSSTSGSRRSRRRSGDGEPSGAPPLPPPPPAVSYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDTDHDYPPGLLIVFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKRQAGQPSPTKPPAESVIVANHSDSSGITPGEAAAIASTAIMVPCGLVFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHSLTPGTHYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	PEPAPPPSHSNPELP CCCCCCCCCCCCCCC	45.37	30352176
12	Phosphorylation	PAPPPSHSNPELPVS CCCCCCCCCCCCCCC	59.42	17242355
19	Phosphorylation	SNPELPVSGGSSTSG CCCCCCCCCCCCCCC	35.18	17242355
22	Phosphorylation	ELPVSGGSSTSGSRR CCCCCCCCCCCCCCC	33.69	29472430
23	Phosphorylation	LPVSGGSSTSGSRRS CCCCCCCCCCCCCCC	29.84	29472430
24	Phosphorylation	PVSGGSSTSGSRRSR CCCCCCCCCCCCCCC	38.51	29472430
25	Phosphorylation	VSGGSSTSGSRRSRR CCCCCCCCCCCCCCC	36.40	29472430
27	Phosphorylation	GGSSTSGSRRSRRRS CCCCCCCCCCCCCCC	25.04	29472430
30	Phosphorylation	STSGSRRSRRRSGDG CCCCCCCCCCCCCCC	29.09	25338131
212	Phosphorylation	KRQAGQPSPTKPPAE HHCCCCCCCCCCCCC	37.00	21454597
225	N-linked_Glycosylation	AESVIVANHSDSSGI CCEEEEEECCCCCCC	25.05	-
296	Phosphorylation	LDHRGDHSLTPGTHY HHHCCCCCCCCCCCC	38.38	24899341
298	Phosphorylation	HRGDHSLTPGTHYA- HCCCCCCCCCCCCC-	23.76	22817900
301	Phosphorylation	DHSLTPGTHYA---- CCCCCCCCCCC----	16.96	20531401

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRCM1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
197	C	Oxidation	Cys-197 is oxidated, leading to inactivation of channel activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRCM1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CRCM1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.