LEMD2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LEMD2_MOUSE
• UniProt AC: Q6DVA0
• Protein Name: LEM domain-containing protein 2
• Gene Name: Lemd2
• Organism: Mus musculus (Mouse).
• Sequence Length: 511
• Subcellular Localization: Nucleus inner membrane ; Multi-pass membrane protein . Lamina-associated protein residing in the inner nuclear membrane (INM). Localized exclusively to the nuclear envelope, giving rise to a typical rim-like staining of the nuclear periphery.
• Protein Description: Involved in nuclear structure organization. [PubMed: 16339967 Required for maintaining the integrity of the nuclear envelope (By similarity; Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT]
• Protein Sequence: MAGLSDLELRRELQALGFQPGPITDTTRNVYRNKLRRLRGEARLRDDERLREDAGPREDAGPRGPERQREEARLREEAPLRARPAASVLRSEPWPLSPSPPAPSAASDASGPYGNFGASASPWAASRGLSYPPHAGPGPLRRRASVRGSSEDDEDTRTPDRHAPGRGRHWWAPPSASARPHSALLGADARPGLKGSRTGSAGAGRTRPEVGRWLERCLSRLLLWASLGLLLGFLAILWVKMGKPSAPQEAEDNMKLLPVDCERKTDEFCQAKQKAALLELLHELYNFLAIQAGNFECGNPEKLKSKCIPVLEAQEYIANVTSSPSSRFKAALTWILSSNKDVGIWLKGEDPSELATTVDKVVCLESARPRMGIGCRLSRALLTAVTHVLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGLSDLEL ------CCCCCHHHH	27.86	-
5	Phosphorylation	---MAGLSDLELRRE ---CCCCCHHHHHHH	38.95	30352176
87	Phosphorylation	LRARPAASVLRSEPW CCCCCHHHHHHCCCC	24.64	29176673
99	Phosphorylation	EPWPLSPSPPAPSAA CCCCCCCCCCCCCCC	39.89	-
113	Phosphorylation	ASDASGPYGNFGASA CCCCCCCCCCCCCCC	28.38	-
130	Phosphorylation	WAASRGLSYPPHAGP HHHHCCCCCCCCCCC	38.12	28833060
131	Phosphorylation	AASRGLSYPPHAGPG HHHCCCCCCCCCCCC	26.31	28833060
145	Phosphorylation	GPLRRRASVRGSSED CCCCCCCCCCCCCCC	15.55	25521595
149	Phosphorylation	RRASVRGSSEDDEDT CCCCCCCCCCCCCCC	21.71	25521595
150	Phosphorylation	RASVRGSSEDDEDTR CCCCCCCCCCCCCCC	48.12	25521595
156	Phosphorylation	SSEDDEDTRTPDRHA CCCCCCCCCCCCCCC	34.10	27087446
158	Phosphorylation	EDDEDTRTPDRHAPG CCCCCCCCCCCCCCC	31.47	25159016
182	Phosphorylation	SASARPHSALLGADA CCCCCCCHHHCCCCC	24.24	26824392
196	Phosphorylation	ARPGLKGSRTGSAGA CCCCCCCCCCCCCCC	25.69	26824392
366	Phosphorylation	DKVVCLESARPRMGI CEEEEHHCCCCCCCC	19.34	-
444	Phosphorylation	WEQDMERYPYVGILH HHHHHHHCCEEEEEE	5.89	-
501	Phosphorylation	DMLVWRWTKPSSFSD CEEEEEECCCCCCCC	25.22	25619855
504	Phosphorylation	VWRWTKPSSFSDSER EEEECCCCCCCCCCC	45.64	27742792
505	Phosphorylation	WRWTKPSSFSDSER- EEECCCCCCCCCCC-	36.98	27742792
507	Phosphorylation	WTKPSSFSDSER--- ECCCCCCCCCCC---	42.02	26824392
509	Phosphorylation	KPSSFSDSER----- CCCCCCCCCC-----	33.79	27742792

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LEMD2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LEMD2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LEMD2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LEMD2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-507 AND SER-509, ANDMASS SPECTROMETRY.
PubMed: 17242355