PREB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PREB_MOUSE
• UniProt AC: Q9WUQ2
• Protein Name: Prolactin regulatory element-binding protein
• Gene Name: Preb
• Organism: Mus musculus (Mouse).
• Sequence Length: 417
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass membrane protein . Nucleus . Concentrates at endoplasmic reticulum exit sites.
• Protein Description: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitement of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.; Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription..
• Protein Sequence: MGRRRGVELYRAPFPLYALRIDPKTGLLIAAGGGGAAKTGIKNGVHFLQLELINGCLSASLLHSHDTETRATMNLALAGDILAAGQDAQCQLLRFQVHQQKGSKAEKSGSKEQGPRQRKGAPPAEKKSGAQVHPEGVELKVKNLEAVQTDFSNEPLQKVVCFNHDNTLLATGGTDGHVRVWKVPSLEKVLEFKAHEGEIGDLTLGPDGKLVTVGWDFKASVWQKDQLVTQLQWQENGPASSNTPYRYQACRFGQVPDQLGGLRLFTVQIPHKRLRQPPPCYLTAWDSSTFLPLRTRSCGHEVISCLSVSDSGTFLGLGTVTGSVAIYIAFSLQRLYYVKEAHGIVVTDVTFLPEKGCGPKLLGPHETALFSVAVDSRCQLHLLPSRRSVPVWLLLLLCVGLIIVTILLLQTAFPGFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Nitrated tyrosine	RRRGVELYRAPFPLY CCCCCEEEECCCCEE	7.39	-
10	Nitration	RRRGVELYRAPFPLY CCCCCEEEECCCCEE	7.39	16800626
10	Nitration	RRRGVELYRAPFPLY CCCCCEEEECCCCEE	7.39	16800626
24	Acetylation	YALRIDPKTGLLIAA EEEEECCCCCEEEEE	52.02	23201123
90	S-palmitoylation	AAGQDAQCQLLRFQV HCCCHHHHHHHHHHH	3.10	28526873
128	Phosphorylation	APPAEKKSGAQVHPE CCCHHHCCCCCCCCC	50.89	27841257
140	Malonylation	HPEGVELKVKNLEAV CCCCCEEEEECCEEE	37.34	26320211
142	Ubiquitination	EGVELKVKNLEAVQT CCCEEEEECCEEEEC	54.98	-
142	Malonylation	EGVELKVKNLEAVQT CCCEEEEECCEEEEC	54.98	26320211
161	S-nitrosocysteine	EPLQKVVCFNHDNTL CCCCEEEEECCCCCE	2.94	-
161	S-nitrosylation	EPLQKVVCFNHDNTL CCCCEEEEECCCCCE	2.94	20925432
188	Ubiquitination	WKVPSLEKVLEFKAH EECCCHHHHEEEEEE	58.37	-
272	Ubiquitination	FTVQIPHKRLRQPPP EEEECCCCCCCCCCC	48.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PREB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PREB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PREB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCH2_MOUSE	Trip13	physical	20211142
PREB_HUMAN	PREB	physical	20360068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Nitration

"Endogenously nitrated proteins in mouse brain: links toneurodegenerative disease.";
Sacksteder C.A., Qian W.-J., Knyushko T.V., Wang H., Chin M.H.,Lacan G., Melega W.P., Camp D.G. II, Smith R.D., Smith D.J.,Squier T.C., Bigelow D.J.;
Biochemistry 45:8009-8022(2006).
Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-10, AND MASS SPECTROMETRY.
PubMed: 16800626