| UniProt ID | RB11A_MOUSE | |
|---|---|---|
| UniProt AC | P62492 | |
| Protein Name | Ras-related protein Rab-11A | |
| Gene Name | Rab11a | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 216 | |
| Subcellular Localization |
Cell membrane Lipid-anchor . Recycling endosome membrane Lipid-anchor . Cleavage furrow . Cytoplasmic vesicle, phagosome . Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localize |
|
| Protein Description | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes.. | |
| Protein Sequence | MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MGTRDDEYD ------CCCCHHHHC | 29.47 | - | |
| 3 | Phosphorylation | -----MGTRDDEYDY -----CCCCHHHHCE | 29.62 | 22499769 | |
| 8 | Phosphorylation | MGTRDDEYDYLFKVV CCCCHHHHCEEEEEE | 19.51 | 22499769 | |
| 10 | Phosphorylation | TRDDEYDYLFKVVLI CCHHHHCEEEEEEEE | 17.09 | 28066266 | |
| 20 | Phosphorylation | KVVLIGDSGVGKSNL EEEEECCCCCCHHHH | 30.11 | 25338131 | |
| 24 | Ubiquitination | IGDSGVGKSNLLSRF ECCCCCCHHHHHHHH | 33.49 | - | |
| 40 | Phosphorylation | RNEFNLESKSTIGVE CCCCCCCCCCEEEEE | 34.76 | - | |
| 42 | Phosphorylation | EFNLESKSTIGVEFA CCCCCCCCEEEEEEE | 34.24 | 26824392 | |
| 43 | Phosphorylation | FNLESKSTIGVEFAT CCCCCCCEEEEEEEE | 26.03 | 19060867 | |
| 52 | Phosphorylation | GVEFATRSIQVDGKT EEEEEEEEEEECCEE | 17.02 | - | |
| 73 | Phosphorylation | DTAGQERYRAITSAY CCCCHHHHHHHHHHH | 12.02 | 29514104 | |
| 77 | Phosphorylation | QERYRAITSAYYRGA HHHHHHHHHHHHHHH | 13.30 | 26745281 | |
| 78 | Phosphorylation | ERYRAITSAYYRGAV HHHHHHHHHHHHHHH | 14.25 | 26824392 | |
| 80 | Phosphorylation | YRAITSAYYRGAVGA HHHHHHHHHHHHHHH | 8.08 | 28066266 | |
| 115 | Phosphorylation | ELRDHADSNIVIMLV HHHHCCCCCEEEEEE | 29.28 | 22817900 | |
| 145 | Ubiquitination | EARAFAEKNGLSFIE HHHHHHHHHCCCEEE | 53.54 | - | |
| 167 | Phosphorylation | NVEAAFQTILTEIYR CHHHHHHHHHHHHHH | 16.11 | - | |
| 170 | Phosphorylation | AAFQTILTEIYRIVS HHHHHHHHHHHHHHC | 19.24 | - | |
| 173 | Phosphorylation | QTILTEIYRIVSQKQ HHHHHHHHHHHCHHH | 6.51 | - | |
| 179 | Ubiquitination | IYRIVSQKQMSDRRE HHHHHCHHHHCCCCC | 40.22 | 22790023 | |
| 182 | Phosphorylation | IVSQKQMSDRRENDM HHCHHHHCCCCCCCC | 26.02 | 23375375 | |
| 190 | Phosphorylation | DRRENDMSPSNNVVP CCCCCCCCCCCCEEC | 28.21 | 25521595 | |
| 192 | Phosphorylation | RENDMSPSNNVVPIH CCCCCCCCCCEECCC | 33.46 | 25521595 | |
| 203 | Phosphorylation | VPIHVPPTTENKPKV ECCCCCCCCCCCCCC | 40.44 | 20415495 | |
| 204 | Phosphorylation | PIHVPPTTENKPKVQ CCCCCCCCCCCCCCE | 43.25 | 25521595 | |
| 212 | Geranylgeranylation | ENKPKVQCCQNI--- CCCCCCEECCCC--- | 2.63 | - | |
| 213 | Methylation | NKPKVQCCQNI---- CCCCCEECCCC---- | 1.62 | - | |
| 213 | Geranylgeranylation | NKPKVQCCQNI---- CCCCCEECCCC---- | 1.62 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RB11A_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RB11A_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RB11A_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| OPTN_MOUSE | Optn | physical | 22465952 | |
| RB11A_MOUSE | Rab11a | physical | 22465952 | |
| ADT2_HUMAN | SLC25A5 | physical | 26496610 | |
| PHB_HUMAN | PHB | physical | 26496610 | |
| EVI5_HUMAN | EVI5 | physical | 26496610 | |
| RB11B_HUMAN | RAB11B | physical | 26496610 | |
| CHK2_HUMAN | CHEK2 | physical | 26496610 | |
| PHB2_HUMAN | PHB2 | physical | 26496610 | |
| RFIP2_HUMAN | RAB11FIP2 | physical | 26496610 | |
| WDR44_HUMAN | WDR44 | physical | 26496610 | |
| RFIP1_HUMAN | RAB11FIP1 | physical | 26496610 | |
| EVI5L_HUMAN | EVI5L | physical | 26496610 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
