FIBG_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FIBG_MOUSE
• UniProt AC: Q8VCM7
• Protein Name: Fibrinogen gamma chain
• Gene Name: Fgg
• Organism: Mus musculus (Mouse).
• Sequence Length: 436
• Subcellular Localization: Secreted .
• Protein Description: Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix (By similarity). Fibrin has a major function in hemostasis as one of the primary components of blood clots (By similarity). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (By similarity). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (By similarity). Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. [PubMed: 19332769 Maternal fibrinogen is essential for successful pregnancy (By similarity Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (By similarity May also facilitate the immune response via both innate and T-cell mediated pathways (By similarity]
• Protein Sequence: MSWSLQPPSFLLCCLLLLFSPTGLAYVATRDNCCILDERFGSFCPTTCGIADFLSSYQTDVDNDLRTLEDILFRAENRTTEAKELIKAIQVYYNPDQPPKPGMIDSATQKSKKMVEEIVKYEALLLTHETSIRYLQEIYNSNNQKITNLKQKVAQLEAQCQEPCKDSVQIHDTTGKDCQEIANKGAKESGLYFIRPLKAKQQFLVYCEIDGSGNGWTVLQKRIDGSLDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISMQSTIPYALRIQLKDWNGRTSTADYAMFRVGPESDKYRLTYAYFIGGDAGDAFDGYDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYHQGGTYSKSSTTNGFDDGIIWATWKSRWYSMKETTMKIIPFNRLSIGEGQQHHMGGSKQAGDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	N-linked_Glycosylation	DILFRAENRTTEAKE HHHHHCCCCCHHHHH	45.68	-
83	Ubiquitination	ENRTTEAKELIKAIQ CCCCHHHHHHHHHHH	46.98	-
100	Ubiquitination	YNPDQPPKPGMIDSA CCCCCCCCCCCCCCC	61.97	-
145	Ubiquitination	IYNSNNQKITNLKQK HHHCCCCEECCHHHH	54.33	-
184	Ubiquitination	DCQEIANKGAKESGL CHHHHHHCCCHHHCE	51.75	-
231	Ubiquitination	DGSLDFKKNWIQYKE CCCCCCHHCEEEECC	58.47	-
430	Phosphorylation	QQHHMGGSKQAGDV- CCCCCCCCCCCCCC-	18.83	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FIBG_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FIBG_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FIBG_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FIBG_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.