MCCA_MOUSE - dbPTM
MCCA_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MCCA_MOUSE
UniProt AC Q99MR8
Protein Name Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
Gene Name Mccc1
Organism Mus musculus (Mouse).
Sequence Length 717
Subcellular Localization Mitochondrion matrix.
Protein Description Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism..
Protein Sequence MAAAALLAAVDRNQLRRVPILLLQPREWAWKLRTMKYGTTPGGSITKVLIANRGEIACRVIRTAKKMGVQSVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLAMEKIIQVAKSSAAQAIHPGYGFLSENMEFAELCKQEGIIFIGPPSSAIRDMGIKSTSKSIMAAAGVPVVEGYHGKDQSDQCLREHAGKIGYPVMIKAVRGGGGKGMRIVRSEREFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGINPEVRRKLGEAAVRAAKAVKYVGAGTVEFIMDSRHNFYFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEIPLQGHAFEARIYAEDPDNNFMPGAGPLVHLSTPSADMSTRIETGVRQGDEVSVHYDPMIAKLVVWASDRQSALSKLRYCLHQYNIVGLRSNVDFLLRLSGHPEFEAGNVHTDFIPQHHKDLLPSHSTIAKESVCQAALGLILKEKEMTSAFKLHTQDQFSPFSFSSGRRLNISYTRNMTLRSGKSDIVIAVTYNRDGSYDMQIDNKSFRVLGDLSSEDGCTYLKSSINGVARKSKFILLDNTVHLFSMEGSIEVGIPVPKYLSPVSAEGAQGGTIAPMTGTIEKVFVKAGDRVKAGDSLMVMIAMKMEHTIKAPKDGRIKKVFFSEGAQANRHAPLVEFEEEESDK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
58S-nitrosocysteineANRGEIACRVIRTAK
ECCCHHHHHHHHHHH		4.36-
58S-palmitoylationANRGEIACRVIRTAK
ECCCHHHHHHHHHHH		4.3626165157
58S-nitrosylationANRGEIACRVIRTAK
ECCCHHHHHHHHHHH		4.3621278135
150PhosphorylationIIFIGPPSSAIRDMG
EEEECCCHHHHHHCC		35.2226026062
151PhosphorylationIFIGPPSSAIRDMGI
EEECCCHHHHHHCCC		33.2326026062
180SuccinylationVVEGYHGKDQSDQCL
EEECCCCCCHHHHHH		39.0023806337
180AcetylationVVEGYHGKDQSDQCL
EEECCCCCCHHHHHH		39.0023576753
186S-nitrosocysteineGKDQSDQCLREHAGK
CCCHHHHHHHHHCCC		4.67-
186S-nitrosylationGKDQSDQCLREHAGK
CCCHHHHHHHHHCCC		4.6721278135
193AcetylationCLREHAGKIGYPVMI
HHHHHCCCCCCCEEE		33.4723576753
216PhosphorylationKGMRIVRSEREFQEQ
CCCEEECCHHHHHHH		30.0624759943
226PhosphorylationEFQEQLESARREAKK
HHHHHHHHHHHHHHH		35.3530165576
233MalonylationSARREAKKSFNDDAM
HHHHHHHHHCCCCHH		68.2926320211
233AcetylationSARREAKKSFNDDAM
HHHHHHHHHCCCCHH		68.2923576753
233SuccinylationSARREAKKSFNDDAM
HHHHHHHHHCCCCHH		68.2924315375
244AcetylationDDAMLIEKFVDTPRH
CCHHHHHHHCCCCCE		43.6323201123
297MalonylationINPEVRRKLGEAAVR
CCHHHHHHHHHHHHH		50.7226320211
363AcetylationLRIAAGEKIPLSQEE
HHHHCCCCCCCCCCC		49.0223864654
450S-nitrosocysteineALSKLRYCLHQYNIV
HHHHHHHHHHHCCEE		1.90-
450S-nitrosylationALSKLRYCLHQYNIV
HHHHHHHHHHHCCEE		1.9021278135
490AcetylationDFIPQHHKDLLPSHS
CCCCHHHHHCCCCCC		48.2023576753
501AcetylationPSHSTIAKESVCQAA
CCCCHHHHHHHHHHH		46.8223576753
505S-nitrosocysteineTIAKESVCQAALGLI
HHHHHHHHHHHHHHH		2.95-
505S-palmitoylationTIAKESVCQAALGLI
HHHHHHHHHHHHHHH		2.9528526873
505S-nitrosylationTIAKESVCQAALGLI
HHHHHHHHHHHHHHH		2.9521278135
514AcetylationAALGLILKEKEMTSA
HHHHHHHCHHHHCCC		60.8023864654
555SuccinylationNMTLRSGKSDIVIAV
CCEECCCCCCEEEEE		46.3223954790
577AcetylationYDMQIDNKSFRVLGD
EEEEECCCEEEEEEC		47.4223576753
577SuccinylationYDMQIDNKSFRVLGD
EEEEECCCEEEEEEC		47.42-
577SuccinylationYDMQIDNKSFRVLGD
EEEEECCCEEEEEEC		47.4223806337
591S-nitrosylationDLSSEDGCTYLKSSI
CCCCCCCCHHHHHHH		3.3221278135
591S-palmitoylationDLSSEDGCTYLKSSI
CCCCCCCCHHHHHHH		3.3228526873
591S-nitrosocysteineDLSSEDGCTYLKSSI
CCCCCCCCHHHHHHH		3.32-
632PhosphorylationVGIPVPKYLSPVSAE
ECCCCCCCCCCCCCC		13.3229899451
652PhosphorylationTIAPMTGTIEKVFVK
CCCCCCCEEEEEEEE		19.4529899451
659AcetylationTIEKVFVKAGDRVKA
EEEEEEEECCCCEEC		34.8823201123
677AcetylationLMVMIAMKMEHTIKA
EEEEEEHHHHHEEEC		31.9219852735
677N6-biotinyllysineLMVMIAMKMEHTIKA
EEEEEEHHHHHEEEC		31.92-
677BiotinylationLMVMIAMKMEHTIKA
EEEEEEHHHHHEEEC		31.92-
692MalonylationPKDGRIKKVFFSEGA
CCCCCEEEEEECCCC		41.7326320211
692AcetylationPKDGRIKKVFFSEGA
CCCCCEEEEEECCCC		41.7323576753
715PhosphorylationVEFEEEESDK-----
EECCHHHCCC-----		54.7225521595
717AcetylationFEEEESDK-------
CCHHHCCC-------		72.0823864654
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MCCA_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MCCA_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MCCA_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MCCA_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MCCA_MOUSE

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Related Literatures of Post-Translational Modification

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