SORC2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SORC2_MOUSE
• UniProt AC: Q9EPR5
• Protein Name: VPS10 domain-containing receptor SorCS2
• Gene Name: Sorcs2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1159
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Sequence: MAHRGPPSAPKRPGPTAPDRSFQALLPPCWPRSWPLLLLLLVLVAACGAMGRSPQPGRQGPGVQITRLLPAGRTESGDRKDPQARESEPSVPGLGPGSASGPSTDGAPAPGKGRRARAVPVAGAASASRAQVSLISTSFVLKGDATHNQAMVHWTGENSSVILILTKYYHADMGKVLESSLWRSSDFGTTYTKLTLQPGVTTVIDNFYICPANKRKIILVSSSLGDREQSLFLSTDEGATFQKYPVPFLVEMLLFHPKEEDKVLAYTKDSKLYVSSDLGKKWTLLQERVTKDHVFWAVSGVDDDPNLVHVEAQDLSGGYRYYTCLIYNCSAQPHIAPFSGPIDRGSLTVQDEYIFLKATSTNRTKYYVSYRRSDFVLMKLPKYALPKDLQIISTDEQQVFVAVQEWNQVDTYNLYQSDLRGVRYSLVLENVRSSRQAEENVVIDILEVRGVKGVFLANQKVDGKVTTVITYNKGRDWDYLRPPSTDMNGKPTNCQPPDCYLHLHLRWADNPYVSGTVHTKDTAPGLIMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHVLYLDHGGVIAAIKDTSIPLKILKFSVDEGHTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFGHISFRSDWELVKVDFRPSFPRQCGEDDYSSWDLTDLQGDHCIMGQQRSYRKRKSTSWCVKGRSFTSALTSRVCKCRDSDFLCDYGFERSSSSESTANKCSANFWFNPLSPPEDCVLGQTYTSSLGYRKVVSNVCEGGVDLQQSPVQLQCPLQAPRGLQVSIRGEAVAVRPREDVLFVVRQEQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHHYESPGIYRVSVRAENMAGHDEAVLFVQVNSPLQALYLEVVPVIGVNQEVNLTAVLLPLNPNLTVFYWWIGHSLQPLLSLDNSVTTKFTDAGDVRVTVQAACGNSVLQDSRLVRVLDQFQVVPLRFSRELDTFNPNTPEWREDVGLVVTRLLSKETSIPEELLVTVVKPGLPTIADLYVLLPLPRPTRKRSLTSDKRLAAVQQALNSHRISFILRGGLRILVELRDTDTGPQRPGGSGGYWAVVVLFVIGLFAVGAFILYKFKRKRPGRTVYAQMHNEKEQEMTSPVSHSEDAQSTMQGNHSGVVLSINSREMHSYLVG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAHRGPPSAPKRPGP CCCCCCCCCCCCCCC	61.41	-
16	Phosphorylation	APKRPGPTAPDRSFQ CCCCCCCCCCCCCHH	57.65	23140645
21	Phosphorylation	GPTAPDRSFQALLPP CCCCCCCCHHHHCCC	29.14	23140645
133	Phosphorylation	SASRAQVSLISTSFV CCCHHHEEEEEEEEE	14.12	-
158	N-linked_Glycosylation	MVHWTGENSSVILIL EEEEECCCCEEEEEE	40.71	30061605
328	N-linked_Glycosylation	YYTCLIYNCSAQPHI EEEEEEEECCCCCCC	13.28	30061605
362	N-linked_Glycosylation	FLKATSTNRTKYYVS EEEEECCCCEEEEEE	49.76	30061605
366	Phosphorylation	TSTNRTKYYVSYRRS ECCCCEEEEEEEECC	14.42	29895711
600	N-linked_Glycosylation	GHTWSTHNFTSTSVF CCCEECCCCCCEEEE	41.81	30061605
830	N-linked_Glycosylation	GFKAMYVNLTLTGEP CEEEEEEEEEECCCC	15.15	30061605
891	N-linked_Glycosylation	IGVNQEVNLTAVLLP ECCCCCEEEEEEEEE	30.81	30061605
902	N-linked_Glycosylation	VLLPLNPNLTVFYWW EEEECCCCCEEEEEE	47.47	30061605
1110	Phosphorylation	KRKRPGRTVYAQMHN HCCCCCCEEEEEECC	24.63	26824392
1147	O-linked_Glycosylation	NHSGVVLSINSREMH CCCCEEEEECCCCCH	14.23	55414005

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SORC2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SORC2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SORC2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SORC2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"The mouse C2C12 myoblast cell surface N-linked glycoproteome:identification, glycosite occupancy, and membrane orientation.";
Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I.,Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E.,Wollscheid B.;
Mol. Cell. Proteomics 8:2555-2569(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-830, AND MASSSPECTROMETRY.
PubMed: 19656770