RTCA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RTCA_MOUSE
• UniProt AC: Q9D7H3
• Protein Name: RNA 3'-terminal phosphate cyclase
• Gene Name: RtcA
• Organism: Mus musculus (Mouse).
• Sequence Length: 366
• Subcellular Localization: Nucleus, nucleoplasm.
• Protein Description: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity)..
• Protein Sequence: MEGQRVEVDGGIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMVRDLCGGHLEGAEIGSTEITFTPEKIRGGVHTADTKTAGSVCLLMQVSMPCVLFAASPSELRLKGGTNAEMAPQIDYTMMVFKPIAEKFGFTFNCDIKTRGYYPKGGGEVIVRVSPVKRLDPINLTDRGSVTKIYGRAFVAGVLPLKVAKDMAAAAVRCIRKEIRDLYVSIQPVQEARDQAFGNGSGIIIVAETSTGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLIIFMALANGISRIKTGSVTLHTQTAIHFAEQLAKAKFTVKKSEEEEDATKDTYVIECEGIGMANPHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	S-nitrosocysteine	RVSTALSCLLGLPLR EHHHHHHHHHCCCCE	3.65	-
57	Ubiquitination	PQHLSGLEMVRDLCG HHHHCHHHHHHHHHC	38.87	27667366
80	Phosphorylation	GSTEITFTPEKIRGG CCEEEEECHHHCCCC	23.14	-
83	Ubiquitination	EITFTPEKIRGGVHT EEEECHHHCCCCCCC	38.62	-
106	Ubiquitination	VCLLMQVSMPCVLFA HHHEEEECCCEEEEE	10.50	27667366
157	Phosphorylation	TFNCDIKTRGYYPKG EEECEEECCCEECCC	29.66	20139300
160	Phosphorylation	CDIKTRGYYPKGGGE CEEECCCEECCCCCE	17.19	20139300
163	Acetylation	KTRGYYPKGGGEVIV ECCCEECCCCCEEEE	54.81	23806337
163	Malonylation	KTRGYYPKGGGEVIV ECCCEECCCCCEEEE	54.81	26320211
163	Ubiquitination	KTRGYYPKGGGEVIV ECCCEECCCCCEEEE	54.81	27667366
173	Phosphorylation	GEVIVRVSPVKRLDP CEEEEEEECCCCCCC	17.26	27600695
188	Phosphorylation	INLTDRGSVTKIYGR CCCCCCCCEEEEECC	27.75	28464351
208	Malonylation	VLPLKVAKDMAAAAV ECCHHHHHHHHHHHH	51.53	26320211
316	Phosphorylation	ISRIKTGSVTLHTQT CCEEECCCEEEEHHH	19.70	27841257

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RTCA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RTCA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RTCA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RTCA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.