COPE_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COPE_MOUSE
• UniProt AC: O89079
• Protein Name: Coatomer subunit epsilon
• Gene Name: Cope
• Organism: Mus musculus (Mouse).
• Sequence Length: 308
• Subcellular Localization: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplasmic side o
• Protein Description: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)..
• Protein Sequence: MAPPVPGAVSGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPEREVERDVFLYRAYLAQRKYGVVLDEIKPSSAPELQAVRMFAEYLASENQRDSIVLELDREMSRSVDVTNTTFLLMAASIYFHDQNPDAALRTLHQGDGLECMAMTIQILLKLDRLDLARKELKKMQDQDEDATLTQLATAWVNLAVGGEKLQEAYYIFQELADKCSPTLLLLNGQAACHSAQGRWETAEGVLQEALDKDSGHPETLINLIVLSQHLGKPPEVTNRYLSQLKDAHRAHPFIKEYQAKENDFDRLAMQYAPSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	PPVPGAVSGGSGEVD CCCCCCCCCCCCCCC	36.58	24925903
13	Phosphorylation	PGAVSGGSGEVDELF CCCCCCCCCCCCHHH	34.99	24925903
42	Ubiquitination	INEAQRVKLSSPERE HHHHHCCCCCCCCHH	44.86	27667366
44	Phosphorylation	EAQRVKLSSPEREVE HHHCCCCCCCCHHHH	37.82	26060331
45	Phosphorylation	AQRVKLSSPEREVER HHCCCCCCCCHHHHH	41.01	25338131
65	Acetylation	RAYLAQRKYGVVLDE HHHHHHHHHCEEECC	33.99	22826441
99	Phosphorylation	ASENQRDSIVLELDR HCCCCCCCEEHHHCH	19.45	-
265	Ubiquitination	VLSQHLGKPPEVTNR HHHHHCCCCHHHHHH	64.85	22790023
278	Acetylation	NRYLSQLKDAHRAHP HHHHHHHHHHHHHCH	45.27	22902405
278	Ubiquitination	NRYLSQLKDAHRAHP HHHHHHHHHHHHHCH	45.27	22790023
307	Phosphorylation	LAMQYAPSA------ HHHHHCCCC------	38.14	30482847

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COPE_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COPE_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COPE_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of COPE_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.