HXK3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXK3_MOUSE
• UniProt AC: Q3TRM8
• Protein Name: Hexokinase-3
• Gene Name: Hk3
• Organism: Mus musculus (Mouse).
• Sequence Length: 922
• Protein Sequence: MATIGPSGLHPGERASVCPHEGVPRPSGSLELECLQQFKVTRTQLQQIQASLLCSMEQALKGQDSPAPSVRMLPTYVRSTPHGTEQGDFLVLELGATGASLRVLWVTLTGTKECRVEPRSREFVIPQEVILGAGQQLFDFAARCLSEFLDAYPVENQGLKLGFNFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIQRQGTYRIDVVAMVNDTVGTMMGCELGTRPCEVGLIVDTGTNACYMEEARHVAALDEDRGRTCVSIEWGSFYDEDALGPVLTTFDSALDRESLTPGAQRFEKMIGGLYLGELVRLVLVHLTQHGVLFDGCASPALLSQGCILLDHVAEMEDTATGTARVHTILQDLGLSPRASDAELVQYVCVAVCTRAAQLCAAALAAVLSRLQHSREQQTLQVAVATGGRVFERHPRFLRILKETVTLLAPNCDVSFIPSVDGGGRGVAMVTAVAARLAAHRRILEETLAPFQLTLEQMTVVQAQMREAMIRGLQGEASSLRMLPTYVRATPDGSERGDFLALDLGGTNFRVLLVRVAEGSVQIINQVYSIPECRAQGSGQKLFDHIVDCIVDFQKRQGLSGQSLPLGFTFSFPCKQLGLDQGILLNWTKGFNASGCEGQDVVYLLREAIRRRQAVELNVVAIVNDTVGTMMSCGYDDPRCEMGLIVGTGTNACYMEELRNVASVPGDSGLMCINMEWGAFGDDGSLGTLSTRFDTSVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTNLGVLFRGQKTQCLQARDIFKTKFLSEIESDSLALRQVRAILEDLGLTLTSDDALMVLEVCQAVSRRAAQLCGAGVAAVVEKIRENRGLQELTVSVGVDGTLYKLHPHFSKLVSATVRKLAPQCTVTFLQSEDGSGKGAALVTAVACRLTQMAHV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MATIGPSGLHPGER -CCCCCCCCCCCCCC	49.09	30635358
18	Glutathionylation	PGERASVCPHEGVPR CCCCCCCCCCCCCCC	2.36	24333276
54	Glutathionylation	QIQASLLCSMEQALK HHHHHHHHCHHHHHC	4.40	24333276
65	Phosphorylation	QALKGQDSPAPSVRM HHHCCCCCCCCCCCC	18.31	22802335
169	Glutathionylation	GFNFSFPCHQTGLDR EEEEECCCCCCCCCH	3.32	24333276
184	Ubiquitination	STLISWTKGFRCSGV HHHHHCCCCCCCCCC	50.20	-
189	Phosphorylation	WTKGFRCSGVEGQDV CCCCCCCCCCCCHHH	41.43	22942356
373	Phosphorylation	ILQDLGLSPRASDAE HHHHCCCCCCCCHHH	15.56	22942356
515	Phosphorylation	RGLQGEASSLRMLPT HHHHCCHHHHCCCCE	26.13	-
570	Glutathionylation	QVYSIPECRAQGSGQ EEECCHHHHCCCCHH	3.52	24333276
732	Phosphorylation	TLSTRFDTSVDQASI CCCCCCCCCCCHHCC	28.12	17203969
780	Glutathionylation	FRGQKTQCLQARDIF CCCCCCHHHHHHHHH	3.53	24333276
790	Ubiquitination	ARDIFKTKFLSEIES HHHHHHHHHHHHHHC	44.92	-
793	Phosphorylation	IFKTKFLSEIESDSL HHHHHHHHHHHCCHH	39.39	21454597
799	Phosphorylation	LSEIESDSLALRQVR HHHHHCCHHHHHHHH	25.48	21454597
877	Phosphorylation	YKLHPHFSKLVSATV EECCHHHHHHHHHHH	23.26	-
881	Phosphorylation	PHFSKLVSATVRKLA HHHHHHHHHHHHHHC	28.76	22817900
883	Phosphorylation	FSKLVSATVRKLAPQ HHHHHHHHHHHHCCC	17.21	22817900
892	Phosphorylation	RKLAPQCTVTFLQSE HHHCCCCEEEEEECC	19.82	22817900
894	Phosphorylation	LAPQCTVTFLQSEDG HCCCCEEEEEECCCC	10.65	22817900
898	Phosphorylation	CTVTFLQSEDGSGKG CEEEEEECCCCCCHH	39.54	20415495
902	Phosphorylation	FLQSEDGSGKGAALV EEECCCCCCHHHHHH	50.05	22817900
914	Glutathionylation	ALVTAVACRLTQMAH HHHHHHHHHHHHHHC	2.70	24333276

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXK3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXK3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXK3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HXK3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-732, AND MASSSPECTROMETRY.
PubMed: 17203969