LT4R1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LT4R1_MOUSE
• UniProt AC: O88855
• Protein Name: Leukotriene B4 receptor 1
• Gene Name: Ltb4r
• Organism: Mus musculus (Mouse).
• Sequence Length: 351
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response..
• Protein Sequence: MAANTTSPAAPSSPGGMSLSLLPIVLLSVALAVGLPGNSFVVWSILKRMQKRTVTALLVLNLALADLAVLLTAPFFLHFLARGTWSFREMGCRLCHYVCGISMYASVLLITIMSLDRSLAVARPFMSQKVRTKAFARWVLAGIWVVSFLLAIPVLVYRTVKWNNRTLICAPNYPNKEHKVFHLLFEAITGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHLVNLVEAGRTVAGWDKNSPAGQRLRLARYVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVVKLLEGTGSEVSSTRRGGTLVQTPKDTPACPEPGPTDSFMTSSTIPESSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	N-linked_Glycosylation	----MAANTTSPAAP ----CCCCCCCCCCC	34.06	-
127	Phosphorylation	AVARPFMSQKVRTKA HHHHHHCCHHHHHHH	27.51	17595524
164	N-linked_Glycosylation	YRTVKWNNRTLICAP HHHCCCCCEEEEECC	36.88	-
308	Phosphorylation	VVKLLEGTGSEVSST EEEECCCCCCCCCCC	28.32	29472430
310	Phosphorylation	KLLEGTGSEVSSTRR EECCCCCCCCCCCCC	34.36	29472430
313	Phosphorylation	EGTGSEVSSTRRGGT CCCCCCCCCCCCCCE	23.18	29472430
314	Phosphorylation	GTGSEVSSTRRGGTL CCCCCCCCCCCCCEE	30.98	25266776
315	Phosphorylation	TGSEVSSTRRGGTLV CCCCCCCCCCCCEEE	19.51	29472430
320	Phosphorylation	SSTRRGGTLVQTPKD CCCCCCCEEEECCCC	26.95	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
127	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LT4R1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LT4R1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LT4R1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-320, AND MASSSPECTROMETRY.
PubMed: 19367708