| UniProt ID | UBE3B_MOUSE | |
|---|---|---|
| UniProt AC | Q9ES34 | |
| Protein Name | Ubiquitin-protein ligase E3B | |
| Gene Name | Ube3b | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1070 | |
| Subcellular Localization | ||
| Protein Description | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.. | |
| Protein Sequence | MFTVSQTSRAWFIDRARQAREERLVQKERERSAVTIQALVRSFLCRRRLHRDIRKEIDEFFSADESGSSKRSALCIFKIARRLLFICKTTEDSERLEKLCRSILNSMDAENEPKVWYVSLALSKDLTLLWIKQIKSILWHCCELLGQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRGKGESLRPALNHICANIMGHLNQRGLYSVLQVLLTRGLARPRPCLSKGMLTAAFSLALRPVVAAQFSDNLMRPFIIHVMSVPALVAHLSTVAPERLGVLESHDMLRKFIVFLRDRDRCRDACESLEGCHTLCLMGNLLHLGSLSLRLLEEEMDGFVSALTQMLCYCQKYVAQKKSNLTHWHPVLGWFSQPVDYGLNDSMYLITKQLQFLWAVPLIRILFSDILSRKLLEHAEPAPVQPQPSSPQTVLPVKSLLKRAFQKSASVRNILRPVGGRRVDSAEVRKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTGESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMVLYERDCRRRFAPEDHWLRRDLKPGVLFQELDKDRRRAQLVLQHIPHVVPHKNRVLLFRNMVIKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDIADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MFTVSQTS -------CCCCCCCC | 30.24 | - | |
| 224 | Ubiquitination | LARPRPCLSKGMLTA CCCCCCCCCCCHHHH | 7.03 | 27667366 | |
| 420 | Phosphorylation | APVQPQPSSPQTVLP CCCCCCCCCCCCEEC | 49.78 | 25521595 | |
| 421 | Phosphorylation | PVQPQPSSPQTVLPV CCCCCCCCCCCEECH | 27.92 | 25521595 | |
| 424 | Phosphorylation | PQPSSPQTVLPVKSL CCCCCCCCEECHHHH | 27.65 | 25521595 | |
| 429 | Ubiquitination | PQTVLPVKSLLKRAF CCCEECHHHHHHHHH | 33.18 | 22790023 | |
| 456 | Phosphorylation | VGGRRVDSAEVRKVC CCCCCCCHHHHHHHH | 24.38 | 20531401 | |
| 526 | Ubiquitination | NDTGESKQLLAMLML CCCHHHHHHHHHHHH | 51.49 | 27667366 | |
| 556 | Phosphorylation | EVYEEQISFKLEELV HHHHHHHCCCHHHHH | 18.94 | 22942356 | |
| 624 | Ubiquitination | HWLRRDLKPGVLFQE CHHHCCCCCCCHHHH | 43.97 | 22790023 | |
| 703 | Ubiquitination | GYEQLRQLSQHAMKG HHHHHHHHHHHHHCC | 4.26 | 27667366 | |
| 753 | Ubiquitination | DPALNLFKTTSGDER CHHHHHHCCCCCCCC | 54.80 | 22790023 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UBE3B_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBE3B_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBE3B_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of UBE3B_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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