PTH1R_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTH1R_MOUSE
• UniProt AC: P41593
• Protein Name: Parathyroid hormone/parathyroid hormone-related peptide receptor
• Gene Name: Pth1r
• Organism: Mus musculus (Mouse).
• Sequence Length: 591
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Receptor for parathyroid hormone and for parathyroid hormone-related peptide. [PubMed: 8197183 The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.]
• Protein Sequence: MGTARIAPSLALLLCCPVLSSAYALVDADDVFTKEEQIFLLHRAQAQCDKLLKEVLHTAANIMESDKGWTPASTSGKPRKEKAPGKFYPESKENKDVPTGSRRRGRPCLPEWDNIVCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWEVVPGHNRTWANYSECLKFMTNETREREVFDRLGMIYTVGYSMSLASLTVAVLILAYFRRLHCTRNYIHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPAAAAVGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTIFGWGLPAVFVAVWVGVRATLANTGCWDLSSGHKKWIIQVPILASVVLNFILFINIIRVLATKLRETNAGRCDTRQQYRKLLRSTLVLVPLFGVHYTVFMALPYTEVSGTLWQIQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIRKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRAGLSLPLSPRLLPATTNGHSQLPGHAKPGAPAIENETIPVTMTVPKDDGFLNGSCSGLDEEASGSARPPPLLQEEWETVM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	VDADDVFTKEEQIFL CCCHHCCCHHHHHHH	37.08	23140645
58	Phosphorylation	LLKEVLHTAANIMES HHHHHHHHHHHHHHC	24.25	22871156
70	Phosphorylation	MESDKGWTPASTSGK HHCCCCCCCCCCCCC	20.04	22871156
74	Phosphorylation	KGWTPASTSGKPRKE CCCCCCCCCCCCCCC	43.54	22871156
151	N-linked_Glycosylation	AYRRCDRNGSWEVVP CEEECCCCCCEEECC	35.28	-
161	N-linked_Glycosylation	WEVVPGHNRTWANYS EEECCCCCCCCCCHH	49.33	-
166	N-linked_Glycosylation	GHNRTWANYSECLKF CCCCCCCCHHHHHHH	32.21	-
176	N-linked_Glycosylation	ECLKFMTNETREREV HHHHHHCCCHHHHHH	36.53	-
473	Phosphorylation	VQAEIRKSWSRWTLA HHHHHHHHHHHEEEE	22.04	25338131
475	Phosphorylation	AEIRKSWSRWTLALD HHHHHHHHHEEEEEE	25.65	25338131
484	Ubiquitination	WTLALDFKRKARSGS EEEEEEHHHHHCCCC	53.29	-
489	Phosphorylation	DFKRKARSGSSSYSY EHHHHHCCCCCCCCC	48.13	26160508
491	Phosphorylation	KRKARSGSSSYSYGP HHHHCCCCCCCCCCC	19.84	26160508
492	Phosphorylation	RKARSGSSSYSYGPM HHHCCCCCCCCCCCC	36.50	26160508
493	Phosphorylation	KARSGSSSYSYGPMV HHCCCCCCCCCCCCC	21.57	26160508
494	Phosphorylation	ARSGSSSYSYGPMVS HCCCCCCCCCCCCCC	14.09	29472430
495	Phosphorylation	RSGSSSYSYGPMVSH CCCCCCCCCCCCCCC	26.09	29472430
496	Phosphorylation	SGSSSYSYGPMVSHT CCCCCCCCCCCCCCE	19.60	29472430
501	Phosphorylation	YSYGPMVSHTSVTNV CCCCCCCCCEECCCC	18.13	21082442
503	Phosphorylation	YGPMVSHTSVTNVGP CCCCCCCEECCCCCC	19.86	29472430
504	Phosphorylation	GPMVSHTSVTNVGPR CCCCCCEECCCCCCC	22.86	29472430
506	Phosphorylation	MVSHTSVTNVGPRAG CCCCEECCCCCCCCC	24.77	29472430
519	Phosphorylation	AGLSLPLSPRLLPAT CCCCCCCCCCCCCCC	13.16	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTH1R_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTH1R_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTH1R_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PTH1R_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.