TDRD6_MOUSE - dbPTM
TDRD6_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TDRD6_MOUSE
UniProt AC P61407
Protein Name Tudor domain-containing protein 6 {ECO:0000305}
Gene Name Tdrd6 {ECO:0000312|MGI:MGI:2679727}
Organism Mus musculus (Mouse).
Sequence Length 2134
Subcellular Localization Cytoplasm . Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic
Protein Description Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression..
Protein Sequence MSSTPGLPTPGASLALRVSFVDVHPEVIPVQLWGLVGQRREEYVRLSREIQEAAATRGPWALGGASASPGELCLVQVGLMWHRCRVVSRQAQDSRVFLLDEGRTITAGAGSLAPGRSEFFHLPSEVLGCVLAGLVPAGGGGTGGGEPQQWSPRAVDFLSNLQGKEVHGRVLDVLLLHRLVLLEVPVVSQQMEELGLARQVPDSLFCSLLKRYLTAAGQGSSGAPVLPRAAPKQEHPGLDYFYPQLQLGVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYRAPVGTDDEDSGSATWEEREESPDKPGSPCASCGLDGQWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGLWDCGRGWSRSQVGDLKALILGQAVNAKIEFYCSFEHMYYVTLYGEDGINLNSAFGVQSCCLADWFLQSQGIEEEEEEDEDEVEAAFQSQSPAEEMEAEVSLPSLRSIRLKMNTFYDAQVEFVKSPSEFWIRLRKHKNTFSKLTKRMCSFYSSASKLDGVILRPEPDDLCCVKWKENGYYRATVTRLDSKSVDVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLADIWPLGKTWSQEATSFFKKTVLHKELVVHVLDKQDHQYVIEILDESRMGEENISKVIAQAGFAKFQEFETKENIRLSAHSPGHVSGHFMAEPSKITSAKKAEGDQRAKKDNKTLSVSEALADTVSLSNLSTAQDTEKVTSDPSLLMLNFLKTKPDCCGKGELEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSEPSPYEGDTRVCLAKRTASGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNLIQPMGENPFVWDEKAVQAFSGFIDSARQNNLELKCTVFALASRHEEEWFNVVDLLTPFQSACRFLVEKRLARPVKHQKPLEPSVQLHSYYYSTHDLKIGSEELVYVTHADDPWTFYCQLARNINVLEQLSYNIMQLSKALLNLKASTLAPGTLCLARYTDGNWYRGIIIEKEPSKVFFVDFGNTYIAVDHLLPIPRDAHDVLLLPMQALKCSLSDIPHHIPEEVTAWFQETVLDKSLKALVVAKDPDGRLIIELYDDSVQINASINEKLGLLGYKNRTRRKEKENEIILHETKALEDKKESVKPSLADYLGKPGESKAHSIEIMGESCKPKMGPACKELRYLQGSAKANLVPPYQDSVGNKNDGGFPLTREKKEDIFASSPMSGTKLDSALPERRMGEPSGRDLPPKFCEFPQKTIAPGFKTSVYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQYHTGPQWQSGDVICAVFPEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWGLSVPVCKEMVSYFSQRTDEAQIRCEFVKFQGTWEVILADEHGVIAEDMISRFPCNGNSQAGLTTQTMKGDCLKIANKPNTDTSVLLNWYNPKAKLIKAYATVIDGPEYFWCQFADSEKLQYLETEVQSAGKQLSDRRSCTQCPQIGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGNAEDCVDAKELWSIPSELLLVPMQAFPCCLAGFSVSGGVCPQEGNDYFYDIVTEDVLDITILEIKRDVCNIPLAIVELRSKGENINEKMKKYAKTGVPKNDLSSEKRGPERKGSLASPDLGLKKPSHKIAQDKTFYGEARASELSERLEKDLNIETKTSKFYERSTRSIFNAFENSCKGKMGSERLEGSMDYHFVDRAKFDNNYLITGFNPILAHASEPKELLELSSLEVPLSADNDDECKEFLELESIELQHSPAGEEEKEELGLGSPMAPLSPGCQAGATLESFMMQLPLDCEAEKQLELKLPTPQLSLEDSISPLSAAVSQDIQGSRCSEDERKAGYMGSSDDDHSRSPLLQHGKGGNSPAHDGRNLSEEEFPQFESRDSAALLAPLFSEEEAREGRKCGSMVPAQLQSTYTLKGFSVGSKCVVWSSLRNTWSKCEILELAEEGTRVLNLSNGVEETVSPENVWNGIPKVDKRPSEAVFQTVGKDLPFMPSDDATTKGFSSVSEEEACGGDADSLSTAKLNI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSTPGLPT
------CCCCCCCCC		54.9825293948
3Phosphorylation-----MSSTPGLPTP
-----CCCCCCCCCC		50.9425293948
4Phosphorylation----MSSTPGLPTPG
----CCCCCCCCCCC		30.5725266776
9PhosphorylationSSTPGLPTPGASLAL
CCCCCCCCCCCCEEE		39.1226643407
13PhosphorylationGLPTPGASLALRVSF
CCCCCCCCEEEEEEE		21.7926643407
47PhosphorylationREEYVRLSREIQEAA
HHHHHHHHHHHHHHH		19.8023140645
212PhosphorylationFCSLLKRYLTAAGQG
HHHHHHHHHHHCCCC		13.5521454597
214PhosphorylationSLLKRYLTAAGQGSS
HHHHHHHHHCCCCCC		12.9121454597
292PhosphorylationVYRAPVGTDDEDSGS
HHCCCCCCCCCCCCC		40.2822817900
297PhosphorylationVGTDDEDSGSATWEE
CCCCCCCCCCCCHHC		32.3825293948
299PhosphorylationTDDEDSGSATWEERE
CCCCCCCCCCHHCCC		26.8625293948
301PhosphorylationDEDSGSATWEEREES
CCCCCCCCHHCCCCC		34.8019060867
308PhosphorylationTWEEREESPDKPGSP
CHHCCCCCCCCCCCC		33.3825293948
314PhosphorylationESPDKPGSPCASCGL
CCCCCCCCCCHHCCC		25.9025293948
686PhosphorylationTKENIRLSAHSPGHV
CCCCEEECCCCCCCC		17.6825293948
689PhosphorylationNIRLSAHSPGHVSGH
CEEECCCCCCCCCCC		32.0922817900
694PhosphorylationAHSPGHVSGHFMAEP
CCCCCCCCCCEECCH		22.3722817900
702PhosphorylationGHFMAEPSKITSAKK
CCEECCHHHCCCCCH		28.3525293948
717UbiquitinationAEGDQRAKKDNKTLS
HCCCHHCHHCCCCCC		63.95-
752PhosphorylationEKVTSDPSLLMLNFL
CCCCCCHHHHHHHCC		38.8422817900
1232PhosphorylationPACKELRYLQGSAKA
HHHHHHHHHCCCHHH		18.9226643407
1236PhosphorylationELRYLQGSAKANLVP
HHHHHCCCHHHCCCC		17.4026643407
1245PhosphorylationKANLVPPYQDSVGNK
HHCCCCCCCCCCCCC		20.9126643407
1248PhosphorylationLVPPYQDSVGNKNDG
CCCCCCCCCCCCCCC		19.1926643407
1270PhosphorylationKKEDIFASSPMSGTK
HHHHCCCCCCCCCCC		24.9925293948
1271PhosphorylationKEDIFASSPMSGTKL
HHHCCCCCCCCCCCC		22.6125293948
1274PhosphorylationIFASSPMSGTKLDSA
CCCCCCCCCCCCCCC		46.8525293948
1276PhosphorylationASSPMSGTKLDSALP
CCCCCCCCCCCCCCC		22.5625293948
1697AcetylationKGENINEKMKKYAKT
CCCCHHHHHHHHHHH		52.0819849169
1723PhosphorylationRGPERKGSLASPDLG
CCCCCCCCCCCCCCC		24.6522817900
1726PhosphorylationERKGSLASPDLGLKK
CCCCCCCCCCCCCCC		25.0027180971
1915PhosphorylationQLELKLPTPQLSLED
HEEECCCCCCCCHHH		33.8221082442
1919PhosphorylationKLPTPQLSLEDSISP
CCCCCCCCHHHCCCH		25.1921082442
1923PhosphorylationPQLSLEDSISPLSAA
CCCCHHHCCCHHHHH		18.6522817900
1925PhosphorylationLSLEDSISPLSAAVS
CCHHHCCCHHHHHHC		24.6022817900
1938PhosphorylationVSQDIQGSRCSEDER
HCCCCCCCCCCHHHH		17.4621183079
1941PhosphorylationDIQGSRCSEDERKAG
CCCCCCCCHHHHHHC		47.1521082442
1952PhosphorylationRKAGYMGSSDDDHSR
HHHCCCCCCCCCCCC		17.6722817900
1953PhosphorylationKAGYMGSSDDDHSRS
HHCCCCCCCCCCCCC		39.0522817900
1958PhosphorylationGSSDDDHSRSPLLQH
CCCCCCCCCCCCHHC		41.2621183079
1960PhosphorylationSDDDHSRSPLLQHGK
CCCCCCCCCCHHCCC		23.9422006019
1980PhosphorylationAHDGRNLSEEEFPQF
CCCCCCCCHHHCCCC		46.6519060867
2063PhosphorylationGTRVLNLSNGVEETV
CCEEEECCCCCEEEC		30.3922817900
2069PhosphorylationLSNGVEETVSPENVW
CCCCCEEECCHHHCC		16.8725293948
2071PhosphorylationNGVEETVSPENVWNG
CCCEEECCHHHCCCC		33.6425293948
2112PhosphorylationDATTKGFSSVSEEEA
CCCCCCCCCCCHHHH		38.2025293948
2113PhosphorylationATTKGFSSVSEEEAC
CCCCCCCCCCHHHHC		27.6625293948
2115PhosphorylationTKGFSSVSEEEACGG
CCCCCCCCHHHHCCC		41.0422817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TDRD6_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TDRD6_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TDRD6_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TDRD6_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TDRD6_MOUSE

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Related Literatures of Post-Translational Modification

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