DOC10_MOUSE - dbPTM
DOC10_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DOC10_MOUSE
UniProt AC Q8BZN6
Protein Name Dedicator of cytokinesis protein 10 {ECO:0000305}
Gene Name Dock10 {ECO:0000312|MGI:MGI:2146320}
Organism Mus musculus (Mouse).
Sequence Length 2150
Subcellular Localization Nucleus . Cytoplasm . Cell projection, dendritic spine .
Protein Description Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. [PubMed: 25851601 Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression]
Protein Sequence MAGERTRRFTRSLLRPGQAAELRHSAASAAAVAVSSRQQQRQEKPRLLDPLDYETVIEELEKTYRDDPLQDLLFFPSDDFSTATVSWDIRTLYSTVPEEAEHRAESLLVKEACKFYSSQWYVVNYKYEQYSGDIRQLPRAEHKPEKLPSHSFEVDHEDADKDEDTTSHSSSKGGGGAGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPLQGRKSAELAELGLDPLDNCVTCECTLEETDSSENSLHPDFAKYLTETEDTVKTTRNMGRLNLFSLDPDIDTLKLQKRDSFENELMIKPFEEKAAKRIMIICRALNFNLQGCVTENEYDPVTNIEPFFVSVALYDLRDNRKISADFHVDLNHPAVRQMLSGTPPALENGNIDTGTPRQSEEPHIKGLPEEWLKFPKQAVFSVSDPHSEIVLVAKVEKVLMGNIGSGAEPYIKNPDSNKFAQKILKSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNVDRDSRFSPLYRQESSKMSSEDLLKLVSDYRRADRISKMQSIPGSLDIAVDNIPLEHPNCVTSSFIPVKPFNVSAQSEPTVEVEEFIYDSTKYCRPYRVYKNQIYVYPKHLKYDSQKCFNKARNITVCIEFKNSDDDGAKPMKCIYGKPGGPLFTSSAYTAVLHHSQNPDFSDEVKIELPTQLHGKHHLLFSFYHITCDINAKANAKKKEALETSVGYAWLPLMKHDQIASQEYNIPIATTLPPNYLSIQDPTSAKHGGSDIKWVDGGKPLFKVSTFVVSTVNTQDPHVNAFFRQCQKREKDMSQSPTSSFVRACKNLLNVDKIHSIMSFLPIILNQLFKILVQNEEDEITATVTRVLADIVAKCHEEQLDHSVQSYIKFVFKTKSYKERTIHEELAKNLSDLLKSNDSTIVKHVLEHSWFFFAIILKSMAQHLIDTNKIQLPRAQRFPESYQSELDNLVMGLCDHVIWKCKEAPEETKRANHSVARFLKRCFTFMDRGFVFKMVNNYISMFSSGEFKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESIRELHASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDIRHLALAVLKNLMAKHSFDDRYREPRKQAQIASLYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFQTQTSMKHATSVDTSFSKDVLNSIAAFSSIAISTVNHADSRASLASLDSNPSTTEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISDETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHTTSGHEGHKQHRSQTLPIIRGKNALSNPKLLQMLDNSMNSNSNEIDIVHHVDTEANIATEVCLTILDLLSLFTQVHQRQLQQSDCQNSLMKRVFDTYMLFFQVNQSASALKHVFASLRLFVCKFPSAFFQGPADLCGSFCYEVLKCCNHRSRLTQMEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIADAGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRKGYWKMEKICTPPLLPEDTQPCDSNLLLTTPGGGSMFSMGWPAFLSITPNIKEEGAMKEDSGMQDTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQAVGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFETPFTLSGKKHGGVAEQCKRRTVLTTSHLFPYVKKRIQVISQSSTELNPIEVAIDEMSRKVSELNQLCTTEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQVKLLKEIFRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLSELSAIMNEQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationRTRRFTRSLLRPGQA
HHHHHHHHHCCCCCH		28.7928725479
149PhosphorylationHKPEKLPSHSFEVDH
CCCCCCCCCCEECCC		42.0520531401
151PhosphorylationPEKLPSHSFEVDHED
CCCCCCCCEECCCCC		27.6925521595
165PhosphorylationDADKDEDTTSHSSSK
CCCCCCCCCCCCCCC		28.3121183079
166PhosphorylationADKDEDTTSHSSSKG
CCCCCCCCCCCCCCC		36.4420531401
167PhosphorylationDKDEDTTSHSSSKGG
CCCCCCCCCCCCCCC		24.3822802335
169PhosphorylationDEDTTSHSSSKGGGG
CCCCCCCCCCCCCCC		35.7520531401
170PhosphorylationEDTTSHSSSKGGGGA
CCCCCCCCCCCCCCC		30.5521183079
171PhosphorylationDTTSHSSSKGGGGAG
CCCCCCCCCCCCCCC		38.0321183079
195PhosphorylationLYKGNFNSTVNNTVT
EEECCCCCCCCCEEE		29.6028833060
196PhosphorylationYKGNFNSTVNNTVTV
EECCCCCCCCCEEEE		28.4923375375
200PhosphorylationFNSTVNNTVTVRSFK
CCCCCCCEEEEEEEC		16.6128833060
202PhosphorylationSTVNNTVTVRSFKKR
CCCCCEEEEEEECHH		14.2528833060
292PhosphorylationLNRILQISPEGPLQG
HHHHHHCCCCCCCCC		12.1626745281
302PhosphorylationGPLQGRKSAELAELG
CCCCCCCHHHHHHCC		26.1419060867
350PhosphorylationETEDTVKTTRNMGRL
CCCCHHHHCCCCCCE		27.0122807455
368PhosphorylationSLDPDIDTLKLQKRD
ECCCCCCCHHHHCCC		26.5719060867
370UbiquitinationDPDIDTLKLQKRDSF
CCCCCCHHHHCCCCC		51.47-
376PhosphorylationLKLQKRDSFENELMI
HHHHCCCCCCCCCCC		38.1924704852
456PhosphorylationPAVRQMLSGTPPALE
HHHHHHHHCCCCHHH		34.97-
458PhosphorylationVRQMLSGTPPALENG
HHHHHHCCCCHHHCC		23.79-
469PhosphorylationLENGNIDTGTPRQSE
HHCCCCCCCCCCCCC		38.88-
471PhosphorylationNGNIDTGTPRQSEEP
CCCCCCCCCCCCCCC		19.86-
785PhosphorylationKKKEALETSVGYAWL
CHHHHHHHHHCCHHH		29.5722802335
825PhosphorylationLSIQDPTSAKHGGSD
ECCCCCCCCCCCCCC		40.4822802335
831PhosphorylationTSAKHGGSDIKWVDG
CCCCCCCCCCEEEEC		40.5322802335
834AcetylationKHGGSDIKWVDGGKP
CCCCCCCEEEECCEE		46.27-
875PhosphorylationQKREKDMSQSPTSSF
HHHCHHHCCCCCHHH		37.3325521595
877PhosphorylationREKDMSQSPTSSFVR
HCHHHCCCCCHHHHH		23.8825521595
879PhosphorylationKDMSQSPTSSFVRAC
HHHCCCCCHHHHHHH		42.1025521595
880PhosphorylationDMSQSPTSSFVRACK
HHCCCCCHHHHHHHH		25.7628833060
881PhosphorylationMSQSPTSSFVRACKN
HCCCCCHHHHHHHHH		30.1828833060
1125PhosphorylationANIPDPLTPSESIRE
CCCCCCCCCCHHHHH		30.1122942356
1127PhosphorylationIPDPLTPSESIRELH
CCCCCCCCHHHHHHC		38.4530635358
1129PhosphorylationDPLTPSESIRELHAS
CCCCCCHHHHHHCCC		31.1430635358
1225PhosphorylationRIYLKDLYPFTVNTS
CEEECCCCCEEEECC		13.3630635358
1228PhosphorylationLKDLYPFTVNTSNQG
ECCCCCEEEECCCCC		14.3526745281
1231PhosphorylationLYPFTVNTSNQGSRD
CCCEEEECCCCCCCC		25.3926745281
1232PhosphorylationYPFTVNTSNQGSRDD
CCEEEECCCCCCCCC		23.1927566939
1236PhosphorylationVNTSNQGSRDDLSTN
EECCCCCCCCCCCCC		23.8326745281
1241PhosphorylationQGSRDDLSTNGGFQT
CCCCCCCCCCCCCCC		27.1626745281
1242PhosphorylationGSRDDLSTNGGFQTQ
CCCCCCCCCCCCCCC		45.2230635358
1248PhosphorylationSTNGGFQTQTSMKHA
CCCCCCCCCCHHCCC		31.3930635358
1250PhosphorylationNGGFQTQTSMKHATS
CCCCCCCCHHCCCEE		33.8930635358
1251PhosphorylationGGFQTQTSMKHATSV
CCCCCCCHHCCCEEC		18.9319144319
1256PhosphorylationQTSMKHATSVDTSFS
CCHHCCCEECCCCCC		29.0630635358
1257PhosphorylationTSMKHATSVDTSFSK
CHHCCCEECCCCCCH		20.8426824392
1260PhosphorylationKHATSVDTSFSKDVL
CCCEECCCCCCHHHH		29.5228833060
1261PhosphorylationHATSVDTSFSKDVLN
CCEECCCCCCHHHHH		24.0628833060
1263PhosphorylationTSVDTSFSKDVLNSI
EECCCCCCHHHHHHH		27.9328833060
1289PhosphorylationNHADSRASLASLDSN
CCCCCCCHHHHCCCC		24.2921082442
1292PhosphorylationDSRASLASLDSNPST
CCCCHHHHCCCCCCC		37.6922942356
1295PhosphorylationASLASLDSNPSTTEK
CHHHHCCCCCCCCCC		56.8025521595
1298PhosphorylationASLDSNPSTTEKSSE
HHCCCCCCCCCCCCC		52.8128833060
1299PhosphorylationSLDSNPSTTEKSSEK
HCCCCCCCCCCCCCC		39.9928833060
1300PhosphorylationLDSNPSTTEKSSEKT
CCCCCCCCCCCCCCC		45.8328833060
1318PhosphorylationEKIPRPLSLIGSTLR
CCCCCCHHHCCCCCC		22.1826824392
1322PhosphorylationRPLSLIGSTLRFDKL
CCHHHCCCCCCCCCC		19.7819060867
1323PhosphorylationPLSLIGSTLRFDKLD
CHHHCCCCCCCCCCC		19.4219060867
1400PhosphorylationAAFKFVQSTQNNGTL
HHHHHHHHCCCCCCC		27.0225367039
1401PhosphorylationAFKFVQSTQNNGTLK
HHHHHHHCCCCCCCC		20.4425367039
1406PhosphorylationQSTQNNGTLKGSNPS
HHCCCCCCCCCCCCC		27.6721082442
1438PhosphorylationEGHKQHRSQTLPIIR
CCCCHHHCCCCCCCC		25.9529176673
1440PhosphorylationHKQHRSQTLPIIRGK
CCHHHCCCCCCCCCC		35.4328725479
1451PhosphorylationIRGKNALSNPKLLQM
CCCCCCCCCHHHHHH		48.9929472430
1602PhosphorylationFEFNKQKSIVRSHLQ
CCHHHHHHHHHHHHH		24.6721189417
1663PhosphorylationDLTKRIRTVLMATAQ
HHHHHHHHHHHHHHH		18.6727180971
1755PhosphorylationPPLLPEDTQPCDSNL
CCCCCCCCCCCCCCE		32.52-
1760PhosphorylationEDTQPCDSNLLLTTP
CCCCCCCCCEEEEEC		35.77-
1854PhosphorylationKKLSDLYYDIHRSYL
HHHHHHHHHHHHHHH		18.73-
1946PhosphorylationPKDLDPKYAYIQVTY
HHHCCCCCEEEEEEE		15.2725521595
1948PhosphorylationDLDPKYAYIQVTYVT
HCCCCCEEEEEEEEC		6.7025521595
2128PhosphorylationIKEDQLEYQEELRSH
HHHHHHHHHHHHHHH		29.8025159016
2128 (in isoform 4)Phosphorylation-29.8030635358
2131 (in isoform 4)Phosphorylation-33.6830635358
2153 (in isoform 4)Phosphorylation-25367039
2154 (in isoform 4)Phosphorylation-25367039
2155 (in isoform 4)Phosphorylation-25367039
2158 (in isoform 4)Phosphorylation-30635358
2159 (in isoform 4)Phosphorylation-30635358
2162 (in isoform 4)Phosphorylation-30635358
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DOC10_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DOC10_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DOC10_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC42_MOUSECdc42physical
15710388
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DOC10_MOUSE

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-376; SER-1292; SER-1295AND THR-1440, AND MASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory