RO60_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RO60_MOUSE
• UniProt AC: O08848
• Protein Name: 60 kDa SS-A/Ro ribonucleoprotein
• Gene Name: Trove2
• Organism: Mus musculus (Mouse).
• Sequence Length: 538
• Subcellular Localization: Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs..
• Protein Description: RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation.; May play roles in cilia formation and/or maintenance..
• Protein Sequence: MEGSANQLQPLSETQVVNSEGGCVWQVTDMNRLRRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTAKQEPLLFALAVCSQCADINTKQAAFKAVPEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAVADWYNEKGGMAVALVVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHEEYKEKALSVEAEKLLKYLEAVEKVKRTKDDLEVIHLIEEHQLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLICEKLSNEKLLKKARIHPFHVLIALETYRAGHGLRGKLKWIPDKDILQALDAAFYTTFKTVEPTGKRFLLAVDVSASMNQRALGSVLNASTVAAAMCMVVTRTEKESSVVAFACDMVPFPVTTDMTLQQVLTAMNKVPAGNTDCSLPMIWAQKTDTAADVFVVFTDNETFAGQVHPAVALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRGMLDMCGFDTAALDVIRNFTLDVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGSANQL -------CCCCCCCC	13.69	-
4	Phosphorylation	----MEGSANQLQPL ----CCCCCCCCCCC	15.67	-
19	Phosphorylation	SETQVVNSEGGCVWQ CCCEEECCCCCEEEE	26.47	-
79	Phosphorylation	EVIQEIKSFSQEGRT HHHHHHHHCCCCCCC	35.47	26804993
81	Phosphorylation	IQEIKSFSQEGRTAK HHHHHHCCCCCCCCC	34.12	26804993
86	Phosphorylation	SFSQEGRTAKQEPLL HCCCCCCCCCHHHHH	49.41	26804993
224	Acetylation	ALSVEAEKLLKYLEA CCCHHHHHHHHHHHH	67.19	-
312	Ubiquitination	CEKLSNEKLLKKARI HHHCCCHHHHHHCCC	64.47	22790023
342	Ubiquitination	HGLRGKLKWIPDKDI CCCCCCCEECCCHHH	46.71	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RO60_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RO60_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RO60_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RO60_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.