ADH1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADH1_MOUSE
• UniProt AC: P00329
• Protein Name: Alcohol dehydrogenase 1
• Gene Name: Adh1
• Organism: Mus musculus (Mouse).
• Sequence Length: 375
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MSTAGKVIKCKAAVLWELHKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHVVSGTLVTPLPAVLGHEGAGIVESVGEGVTCVKPGDKVIPLFSPQCGECRICKHPESNFCSRSDLLMPRGTLREGTSRFSCKGKQIHNFISTSTFSQYTVVDDIAVAKIDGASPLDKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVIIGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYSKPIQEVLQEMTDGGVDFSFEVIGRLDTMTSALLSCHAACGVSVVVGVPPNAQNLSMNPMLLLLGRTWKGAIFGGFKSKDSVPKLVADFMAKKFPLDPLITHVLPFEKINEAFDLLRSGKSIRTVLTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSTAGKVIK ------CCCCCCEEE	27.28	-
6	Malonylation	--MSTAGKVIKCKAA --CCCCCCEEEEEHH	38.02	26320211
6	Ubiquitination	--MSTAGKVIKCKAA --CCCCCCEEEEEHH	38.02	-
9	Acetylation	STAGKVIKCKAAVLW CCCCCEEEEEHHHHH	32.44	6569617
9	Ubiquitination	STAGKVIKCKAAVLW CCCCCEEEEEHHHHH	32.44	22790023
11	Ubiquitination	AGKVIKCKAAVLWEL CCCEEEEEHHHHHHC	34.09	22790023
20	Acetylation	AVLWELHKPFTIEDI HHHHHCCCCCEEEEE	55.22	23201123
20	Malonylation	AVLWELHKPFTIEDI HHHHHCCCCCEEEEE	55.22	26073543
20	Ubiquitination	AVLWELHKPFTIEDI HHHHHCCCCCEEEEE	55.22	-
23	Phosphorylation	WELHKPFTIEDIEVA HHCCCCCEEEEEEEC	31.80	20469934
33	Ubiquitination	DIEVAPPKAHEVRIK EEEECCCCCCEEEEE	62.41	22790023
33	Acetylation	DIEVAPPKAHEVRIK EEEECCCCCCEEEEE	62.41	22733758
40	Ubiquitination	KAHEVRIKMVATGVC CCCEEEEEEEEECCC	19.43	-
40	Acetylation	KAHEVRIKMVATGVC CCCEEEEEEEEECCC	19.43	23864654
40	Glutarylation	KAHEVRIKMVATGVC CCCEEEEEEEEECCC	19.43	24703693
40	Malonylation	KAHEVRIKMVATGVC CCCEEEEEEEEECCC	19.43	26073543
47	S-palmitoylation	KMVATGVCRSDDHVV EEEEECCCCCCCCEE	3.49	28526873
83	S-palmitoylation	SVGEGVTCVKPGDKV ECCCCCEEECCCCEE	3.26	28526873
85	Ubiquitination	GEGVTCVKPGDKVIP CCCCEEECCCCEEEE	45.49	-
85	Malonylation	GEGVTCVKPGDKVIP CCCCEEECCCCEEEE	45.49	26073543
89	Ubiquitination	TCVKPGDKVIPLFSP EEECCCCEEEEEECC	48.23	-
89	Malonylation	TCVKPGDKVIPLFSP EEECCCCEEEEEECC	48.23	26073543
98	S-nitrosylation	IPLFSPQCGECRICK EEEECCCCCCCCCCC	5.86	22178444
98	S-palmitoylation	IPLFSPQCGECRICK EEEECCCCCCCCCCC	5.86	28526873
101	S-nitrosylation	FSPQCGECRICKHPE ECCCCCCCCCCCCCC	1.84	22178444
101	S-palmitoylation	FSPQCGECRICKHPE ECCCCCCCCCCCCCC	1.84	28526873
104	S-palmitoylation	QCGECRICKHPESNF CCCCCCCCCCCCCCC	1.39	26165157
104	S-nitrosylation	QCGECRICKHPESNF CCCCCCCCCCCCCCC	1.39	22178444
105	Acetylation	CGECRICKHPESNFC CCCCCCCCCCCCCCC	60.88	22733758
105	Malonylation	CGECRICKHPESNFC CCCCCCCCCCCCCCC	60.88	26320211
105	Ubiquitination	CGECRICKHPESNFC CCCCCCCCCCCCCCC	60.88	-
109	Phosphorylation	RICKHPESNFCSRSD CCCCCCCCCCCCHHH	39.39	22324799
112	S-nitrosylation	KHPESNFCSRSDLLM CCCCCCCCCHHHCCC	3.75	22178444
112	S-palmitoylation	KHPESNFCSRSDLLM CCCCCCCCCHHHCCC	3.75	28526873
113	Phosphorylation	HPESNFCSRSDLLMP CCCCCCCCHHHCCCC	30.59	30352176
136	Ubiquitination	SRFSCKGKQIHNFIS CCEEECCCEEEEEEE	31.41	22790023
150	Phosphorylation	STSTFSQYTVVDDIA ECCCCCCEEEECEEE	10.58	8234003
160	Malonylation	VDDIAVAKIDGASPL ECEEEEEECCCCCCC	34.43	26073543
165	Phosphorylation	VAKIDGASPLDKVCL EEECCCCCCCCEEEE	31.37	23984901
169	Acetylation	DGASPLDKVCLIGCG CCCCCCCEEEEEECC	42.40	22733758
169	Ubiquitination	DGASPLDKVCLIGCG CCCCCCCEEEEEECC	42.40	22790023
171	S-palmitoylation	ASPLDKVCLIGCGFS CCCCCEEEEEECCCC	2.56	28526873
171	S-nitrosylation	ASPLDKVCLIGCGFS CCCCCEEEEEECCCC	2.56	22178444
175	S-nitrosylation	DKVCLIGCGFSTGYG CEEEEEECCCCCCCC	3.84	22178444
175	S-palmitoylation	DKVCLIGCGFSTGYG CEEEEEECCCCCCCC	3.84	28526873
178	Phosphorylation	CLIGCGFSTGYGSAV EEEECCCCCCCCCEE	13.25	23984901
179	Phosphorylation	LIGCGFSTGYGSAVK EEECCCCCCCCCEEE	31.96	23984901
183	Phosphorylation	GFSTGYGSAVKVAKV CCCCCCCCEEEEEEE	22.77	23984901
186	Ubiquitination	TGYGSAVKVAKVTPG CCCCCEEEEEEECCC	35.87	22790023
196	S-nitrosylation	KVTPGSTCAVFGLGG EECCCCEEEEECCCC	3.05	22178444
212	S-nitrosylation	GLSVIIGCKAAGAAR EEEEEECCHHHCCEE	1.59	22178444
227	Acetylation	IIAVDINKDKFAKAK EEEEECCHHHHHHHH	63.73	23201123
227	Ubiquitination	IIAVDINKDKFAKAK EEEEECCHHHHHHHH	63.73	-
227	Malonylation	IIAVDINKDKFAKAK EEEEECCHHHHHHHH	63.73	26320211
229	Acetylation	AVDINKDKFAKAKEL EEECCHHHHHHHHHH	49.16	23201123
229	Ubiquitination	AVDINKDKFAKAKEL EEECCHHHHHHHHHH	49.16	-
229	Malonylation	AVDINKDKFAKAKEL EEECCHHHHHHHHHH	49.16	26073543
232	Acetylation	INKDKFAKAKELGAT CCHHHHHHHHHHCCC	64.22	23201123
234	Ubiquitination	KDKFAKAKELGATEC HHHHHHHHHHCCCCC	53.41	-
234	Acetylation	KDKFAKAKELGATEC HHHHHHHHHHCCCCC	53.41	23806337
234	Succinylation	KDKFAKAKELGATEC HHHHHHHHHHCCCCC	53.41	23806337
234	Malonylation	KDKFAKAKELGATEC HHHHHHHHHHCCCCC	53.41	26320211
234	Succinylation	KDKFAKAKELGATEC HHHHHHHHHHCCCCC	53.41	-
248	Phosphorylation	CINPQDYSKPIQEVL CCCHHHCCHHHHHHH	40.00	25195567
316	Succinylation	LLLGRTWKGAIFGGF HHHCCCCCCCHHCCC	37.54	23806337
316	Acetylation	LLLGRTWKGAIFGGF HHHCCCCCCCHHCCC	37.54	23806337
316	Ubiquitination	LLLGRTWKGAIFGGF HHHCCCCCCCHHCCC	37.54	-
324	Succinylation	GAIFGGFKSKDSVPK CCHHCCCCCCCCHHH	60.93	23954790
324	Ubiquitination	GAIFGGFKSKDSVPK CCHHCCCCCCCCHHH	60.93	-
326	Malonylation	IFGGFKSKDSVPKLV HHCCCCCCCCHHHHH	55.39	26320211
326	Acetylation	IFGGFKSKDSVPKLV HHCCCCCCCCHHHHH	55.39	23864654
331	Ubiquitination	KSKDSVPKLVADFMA CCCCCHHHHHHHHHH	54.13	22790023
331	Acetylation	KSKDSVPKLVADFMA CCCCCHHHHHHHHHH	54.13	22733758
339	Malonylation	LVADFMAKKFPLDPL HHHHHHHHCCCCCHH	43.06	26073543
339	Ubiquitination	LVADFMAKKFPLDPL HHHHHHHHCCCCCHH	43.06	-
339	Acetylation	LVADFMAKKFPLDPL HHHHHHHHCCCCCHH	43.06	23201123
339	Glutarylation	LVADFMAKKFPLDPL HHHHHHHHCCCCCHH	43.06	24703693
340	Ubiquitination	VADFMAKKFPLDPLI HHHHHHHCCCCCHHH	42.55	-
340	Acetylation	VADFMAKKFPLDPLI HHHHHHHCCCCCHHH	42.55	23806337
340	Succinylation	VADFMAKKFPLDPLI HHHHHHHCCCCCHHH	42.55	23806337
340	Succinylation	VADFMAKKFPLDPLI HHHHHHHCCCCCHHH	42.55	-
340	Malonylation	VADFMAKKFPLDPLI HHHHHHHCCCCCHHH	42.55	26320211
355	Acetylation	THVLPFEKINEAFDL HHCCCHHHHHHHHHH	51.73	23954790
355	Malonylation	THVLPFEKINEAFDL HHCCCHHHHHHHHHH	51.73	26073543
365	Phosphorylation	EAFDLLRSGKSIRTV HHHHHHHCCCCCEEE	51.01	23984901
368	Phosphorylation	DLLRSGKSIRTVLTF HHHHCCCCCEEEEEC	22.34	26643407
371	Phosphorylation	RSGKSIRTVLTF--- HCCCCCEEEEEC---	20.42	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADH1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADH1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADH1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ADH1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.