FA10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FA10_MOUSE
• UniProt AC: O88947
• Protein Name: Coagulation factor X
• Gene Name: F10
• Organism: Mus musculus (Mouse).
• Sequence Length: 481
• Subcellular Localization: Secreted.
• Protein Description: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting..
• Protein Sequence: MGSPVQLSLLCVVLASLLLPGKGVFINRERANNVLARTRRANSFFEEFKKGNLERECMEEICSYEEVREIFEDDEKTKEYWTKYKDGDQCESSPCQNQGACRDGIGGYTCTCSEGFEGKNCELFVRKLCRLDNGDCDQFCREEQNSVVCSCASGYFLGNDGKSCISTAPFPCGKITTGRRKRSVALNTSDSELDLEDALLDEDFLSPTENPIELLNLNETQPERSSDDLVRIVGGRECKDGECPWQALLINEDNEGFCGGTILNEFYILTAAHCLHQARRFKVRVGDRNTEKEEGNEMVHEVDVVIKHNKFQRDTYDYDIAVLRLKTPITFRMNVAPACLPQKDWAESTLMTQKTGIVSGFGRTHEKGRQSNILKMLEVPYVDRNTCKLSTSFSITQNMFCAGYEAKLEDACQGDSGGPHVTRFKNTYYVTGIVSWGEGCARKGKYGIYTKVTTFLKWIDRSMKARVGPTAETPRTAGPPN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	4-carboxyglutamate	RRANSFFEEFKKGNL HHHHHHHHHHHCCCC	61.59	-
46	Gamma-carboxyglutamic_acid	RRANSFFEEFKKGNL HHHHHHHHHHHCCCC	61.59	-
47	4-carboxyglutamate	RANSFFEEFKKGNLE HHHHHHHHHHCCCCH	58.57	-
47	Gamma-carboxyglutamic_acid	RANSFFEEFKKGNLE HHHHHHHHHHCCCCH	58.57	-
54	4-carboxyglutamate	EFKKGNLERECMEEI HHHCCCCHHHHHHHH	50.89	-
54	Gamma-carboxyglutamic_acid	EFKKGNLERECMEEI HHHCCCCHHHHHHHH	50.89	-
56	4-carboxyglutamate	KKGNLERECMEEICS HCCCCHHHHHHHHCC	28.92	-
56	Gamma-carboxyglutamic_acid	KKGNLERECMEEICS HCCCCHHHHHHHHCC	28.92	-
59	Gamma-carboxyglutamic_acid	NLERECMEEICSYEE CCHHHHHHHHCCHHH	56.73	-
59	4-carboxyglutamate	NLERECMEEICSYEE CCHHHHHHHHCCHHH	56.73	-
60	Gamma-carboxyglutamic_acid	LERECMEEICSYEEV CHHHHHHHHCCHHHH	23.55	-
60	4-carboxyglutamate	LERECMEEICSYEEV CHHHHHHHHCCHHHH	23.55	-
65	Gamma-carboxyglutamic_acid	MEEICSYEEVREIFE HHHHCCHHHHHHHHC	33.45	-
65	4-carboxyglutamate	MEEICSYEEVREIFE HHHHCCHHHHHHHHC	33.45	-
66	Gamma-carboxyglutamic_acid	EEICSYEEVREIFED HHHCCHHHHHHHHCC	38.35	-
66	4-carboxyglutamate	EEICSYEEVREIFED HHHCCHHHHHHHHCC	38.35	-
69	4-carboxyglutamate	CSYEEVREIFEDDEK CCHHHHHHHHCCCHH	58.15	-
69	Gamma-carboxyglutamic_acid	CSYEEVREIFEDDEK CCHHHHHHHHCCCHH	58.15	-
72	4-carboxyglutamate	EEVREIFEDDEKTKE HHHHHHHCCCHHHHH	70.93	-
72	Gamma-carboxyglutamic_acid	EEVREIFEDDEKTKE HHHHHHHCCCHHHHH	70.93	-
75	Gamma-carboxyglutamic_acid	REIFEDDEKTKEYWT HHHHCCCHHHHHHHH	74.97	-
75	4-carboxyglutamate	REIFEDDEKTKEYWT HHHHCCCHHHHHHHH	74.97	-
79	Gamma-carboxyglutamic_acid	EDDEKTKEYWTKYKD CCCHHHHHHHHCCCC	52.08	-
79	4-carboxyglutamate	EDDEKTKEYWTKYKD CCCHHHHHHHHCCCC	52.08	-
103	Hydroxylation	QNQGACRDGIGGYTC CCCCCCCCCCCCEEE	53.60	-
187	N-linked_Glycosylation	RKRSVALNTSDSELD CCCEEECCCCCCCCC	28.00	16944957
218	N-linked_Glycosylation	PIELLNLNETQPERS CCHHHCCCCCCCCCC	49.55	-
326	Ubiquitination	DIAVLRLKTPITFRM EEEEEEECCCEEEEE	45.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FA10_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FA10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FA10_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FA10_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Proteome-wide characterization of N-glycosylation events by diagonalchromatography.";
Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J.,Gevaert K.;
J. Proteome Res. 5:2438-2447(2006).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-187, AND MASSSPECTROMETRY.
PubMed: 16944957