dbPTM

DYM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DYM_MOUSE
UniProt AC	Q8CHY3
Protein Name	Dymeclin
Gene Name	Dym
Organism	Mus musculus (Mouse).
Sequence Length	669
Subcellular Localization	Cytoplasm. Golgi apparatus. Membrane Lipid-anchor . Sequence analysis programs predict 1 transmembrane region. However, it has been shown in human that it is not a stably anchored transmembrane protein but it weakly associates with the Golgi appara
Protein Description	Necessary for correct organization of Golgi apparatus. Involved in bone development..
Protein Sequence	MGSNSSKISDLPKNEYLKKLSGPESISENDPFWNQLFSFSFPAPTSSSELKLLEEATISVCKSLVENNPRTGNLAALTKVFLSRTRELRLSAECQNHIFIWQTHNALFIICCLLKVFIRELSEEELQLHFTYEEKSPGSYSSDSEDLLEELLCSLVQLITDTPLLDITYEIAVEAISAMVVFLSCQLFHKEVLRQSISHKYLMQGPCLPYTSKLVKTLLYNFIRQEKPPPPGTHVFPQQSDGGGLLYGLASGVATGLWTVFTLGGAGSKAAASPELTSPLANQSLLLLLVLVNLTDAPDIPNPYRQAVSSFKNTQDSSPFPSSIPHTFQINFNSLYTALCEQQTSDQATLLLYTLLHQNSNVRTYVLARTDMENLVLPILEILYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVILRNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNCLAALANMSAQFRSLHQYAAQRIISLFSLLSKKHNKVLEQATQSLRGPLSSSDVPLPDYAQDLSVIEEVIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVISFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKKFPELKFKYVEEEQPEEFFIPYVWSLVYNSAVGLYWNPQDIQLFAMDSD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGSNSSKIS ------CCCCCCCCC	35.22	-
13	Ubiquitination	SKISDLPKNEYLKKL CCCCCCCHHHHHHHH	70.48	22790023
57	Phosphorylation	LKLLEEATISVCKSL HHHHHHHHHHHHHHH	19.64	25338131
452	Phosphorylation	RTIQYNMTRTRDKYL HHHHHCCCCCCCHHH	25.83	23608596
490	Phosphorylation	QRIISLFSLLSKKHN HHHHHHHHHHHHHHH	33.42	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DYM_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DYM_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DYM_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DYM_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DYM_MOUSE

Related Literatures of Post-Translational Modification