dbPTM

BAG5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BAG5_MOUSE
UniProt AC	Q8CI32
Protein Name	BAG family molecular chaperone regulator 5
Gene Name	Bag5
Organism	Mus musculus (Mouse).
Sequence Length	447
Subcellular Localization
Protein Description	May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity)..
Protein Sequence	MDMGNQHPSISRLQEIQREVKAIEPQVVGFSGLSDDKNYKRLERILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQNANHPHRIEIQNIFKEAQALVKDKIVPFYSGGNCVTDEFEEGIQDIILRLTHVKTGGKVSLRKARYRTLTKICAVQEVIEDCMKKQPSLPLSEDVHPSVAKINSVMCEVNKARGTLIALLMGVDSSETCRHLSCVLSGLIADLDALDVCGRTEIRNYRREVVEDINKLLKYLDLEEEADSTHAFDLGQNHSIIKIENVLKRMREIKNELLQAQSPPELYLRAKTELQGLIGQLDEVSLEKNPCIREARRRAVIEVQILITYLDLKEALEKRKLFPCEEHPPHKAVWEILGNLSEILGEVLSFGGNRTDKNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVKLAQNILSYLDMKSDEWEY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Ubiquitination	RLERILTKQLFEIDS HHHHHHHHHHHCCCC	41.37	22790023
75	Phosphorylation	RKRAAQETERLLKEL HHHHHHHHHHHHHHH	17.83	29514104
140	Ubiquitination	RLTHVKTGGKVSLRK HHHCCCCCCCEEECH	28.36	27667366
264	Phosphorylation	DLEEEADSTHAFDLG CHHHHHCCCCEEECC	29.19	29899451
265	Phosphorylation	LEEEADSTHAFDLGQ HHHHHCCCCEEECCC	20.12	29899451
303	Phosphorylation	AQSPPELYLRAKTEL CCCCCHHHHHHHHHH	7.77	21454597
404	Ubiquitination	RLEELLTKQLLALDA CHHHHHHHHHHHHHC	38.63	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BAG5_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BAG5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BAG5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of BAG5_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BAG5_MOUSE

Related Literatures of Post-Translational Modification