DHCR7_MOUSE - dbPTM
DHCR7_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DHCR7_MOUSE
UniProt AC O88455
Protein Name 7-dehydrocholesterol reductase
Gene Name Dhcr7
Organism Mus musculus (Mouse).
Sequence Length 471
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein.
Protein Description Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC)..
Protein Sequence MASKSQHNAPKVKSPNGKAGSQGQWGRAWEVDWFSLASIIFLLLFAPFIVYYFIMACDQYSCSLTAPALDIATGHASLADIWAKTPPVTAKAAQLYALWVSFQVLLYSWLPDFCHRFLPGYVGGVQEGAITPAGVVNKYEVNGLQAWLITHILWFVNAYLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIKGYLFPTSAEDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMILVNVLQAIYVLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPNALGILLLGLVGYYIFRMTNHQKDLFRRTDGRCLIWGKKPKAIECSYTSADGLKHHSKLLVSGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIYMTILLTHRCLRDEHRCANKYGRDWERYTAAVPYRLLPGIF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationHNAPKVKSPNGKAGS
CCCCCCCCCCCCCCC		26.95-
18UbiquitinationKVKSPNGKAGSQGQW
CCCCCCCCCCCCCCC		57.10-
18MalonylationKVKSPNGKAGSQGQW
CCCCCCCCCCCCCCC		57.1026320211
21PhosphorylationSPNGKAGSQGQWGRA
CCCCCCCCCCCCCCC		35.6822324799
205S-palmitoylationFPTSAEDCKFTGNFF
CCCCHHHCCCCCCCH		2.6928526873
369AcetylationGRCLIWGKKPKAIEC
CCEEEECCCCCEEEC		51.4023201123
370MalonylationRCLIWGKKPKAIECS
CEEEECCCCCEEECE		48.0526320211
372MalonylationLIWGKKPKAIECSYT
EEECCCCCEEECEEE		71.5226320211
376S-palmitoylationKKPKAIECSYTSADG
CCCCEEECEEECCCC		2.8528526873
377PhosphorylationKPKAIECSYTSADGL
CCCEEECEEECCCCC		20.7523140645
378PhosphorylationPKAIECSYTSADGLK
CCEEECEEECCCCCC		19.1723140645
379PhosphorylationKAIECSYTSADGLKH
CEEECEEECCCCCCH		10.9323140645
385MalonylationYTSADGLKHHSKLLV
EECCCCCCHHHHHHH		44.8126320211
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DHCR7_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DHCR7_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DHCR7_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DHCR7_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DHCR7_MOUSE

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Related Literatures of Post-Translational Modification

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