JAML_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JAML_MOUSE
• UniProt AC: Q80UL9
• Protein Name: Junctional adhesion molecule-like {ECO:0000250|UniProtKB:Q86YT9}
• Gene Name: Jaml {ECO:0000250|UniProtKB:Q86YT9}
• Organism: Mus musculus (Mouse).
• Sequence Length: 379
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Cell junction . Localized at the plasma membrane and enriched in areas of cell-cell contacts.
• Protein Description: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR..
• Protein Sequence: MLCLLKLIVIPVILAPVGYPQGLPGLTVSSPQLRVHVGESVLMGCVVQRTEEKHVDRVDWLFSKDKDDASEYVLFYYSNLSVPTGRFQNRSHLVGDTFHNDGSLLLQDVQKADEGIYTCEIRLKNESMVMKKPVELWVLPEEPKDLRVRVGDTTQMRCSIQSTEEKRVTKVNWMFSSGSHTEEETVLSYDSNMRSGKFQSLGRFRNRVDLTGDISRNDGSIKLQTVKESDQGIYTCSIYVGKLESRKTIVLHVVQDEFQRTISPTPPTDKGQQGILNGNQLVIIVGIVCATFLLLPVLILIVKKAKWNKSSVSSMASVKSLENKEKINPEKHIYSSITTWETTERGISGESEGTYMTMNPVWPSSPKASSLVRSSVRSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	N-linked_Glycosylation	YVLFYYSNLSVPTGR EEEEEEECCCCCCCC		20813955
89	N-linked_Glycosylation	VPTGRFQNRSHLVGD CCCCCCCCCCEECCC		20813955
125	N-linked_Glycosylation	TCEIRLKNESMVMKK EEEEEECCCCCEECC		20813955
127	Phosphorylation	EIRLKNESMVMKKPV EEEECCCCCEECCCE		24719451
169	Phosphorylation	STEEKRVTKVNWMFS CCCCCEEEEEEEEEE		12417257
237	Phosphorylation	DQGIYTCSIYVGKLE HCCEEEEEEEEEECC		51459713
313	Phosphorylation	KWNKSSVSSMASVKS CCCCCHHHHHHHHHH		29176673
314	Phosphorylation	WNKSSVSSMASVKSL CCCCHHHHHHHHHHH		29176673
317	Phosphorylation	SSVSSMASVKSLENK CHHHHHHHHHHHCCH		29176673
320	Phosphorylation	SSMASVKSLENKEKI HHHHHHHHHCCHHHC		29176673
335	Phosphorylation	NPEKHIYSSITTWET CCCCCHHEEEEEEEE		25266776
336	Phosphorylation	PEKHIYSSITTWETT CCCCHHEEEEEEEEC		25266776
348	Phosphorylation	ETTERGISGESEGTY EECCCCCCCCCCCEE		23140645
351	Phosphorylation	ERGISGESEGTYMTM CCCCCCCCCCEEEEE		23140645
354	Phosphorylation	ISGESEGTYMTMNPV CCCCCCCEEEEECCC		23140645
355	Phosphorylation	SGESEGTYMTMNPVW CCCCCCEEEEECCCC		-
357	Phosphorylation	ESEGTYMTMNPVWPS CCCCEEEEECCCCCC		23140645
364	Phosphorylation	TMNPVWPSSPKASSL EECCCCCCCHHHHHH		23140645
365	Phosphorylation	MNPVWPSSPKASSLV ECCCCCCCHHHHHHH		23140645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JAML_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JAML_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JAML_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of JAML_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.