dbPTM

TM177_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TM177_MOUSE
UniProt AC	Q8BPE4
Protein Name	Transmembrane protein 177
Gene Name	Tmem177
Organism	Mus musculus (Mouse).
Sequence Length	311
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein .
Protein Description	Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein..
Protein Sequence	MAGPLWRAAAFIQRHRTSLLVGSCAGLFGVQISFHLFPDPIVQWLYQYWPQGQPAPLSPHLWSLFQEVLKDIGVPSGHCYKPFTAFTFQPVSAGFPRLPAGAVVGIPAIFLGGPVTNIEHSVIIHGQRVDWQSPAGTRLRDALTMSHNAQKFALAKEVVYLESGVAALQTLPAPACLAGTWAISVGAKHALGLYGGPMSLRTAFNLVAIVVGYVAYTFSKDSLTLALEGWLDRRTASLSAAYVQGGVEFYEKILSGNLALRSLLGRQGEKLYTPSGNIVPRHWFRINHLPYTTRRDSLQQMWRATVSPGRF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
160	Phosphorylation	ALAKEVVYLESGVAA HHHCEEEEHHHCHHH	15.21	26060331
163	Phosphorylation	KEVVYLESGVAALQT CEEEEHHHCHHHHHC	35.65	26060331
170	Phosphorylation	SGVAALQTLPAPACL HCHHHHHCCCCCHHH	35.24	26060331
180	Phosphorylation	APACLAGTWAISVGA CCHHHCCCEEEEECH	13.20	26060331
184	Phosphorylation	LAGTWAISVGAKHAL HCCCEEEEECHHHHH	13.52	26060331
194	Phosphorylation	AKHALGLYGGPMSLR HHHHHHCCCCCCHHH	20.45	26060331
199	Phosphorylation	GLYGGPMSLRTAFNL HCCCCCCHHHHHHHH	20.17	26060331
222	Phosphorylation	AYTFSKDSLTLALEG HHCCCHHHHHHHHHH	27.30	25338131
297	Phosphorylation	PYTTRRDSLQQMWRA CCCCCHHHHHHHHHH	26.68	22817900
307	Phosphorylation	QMWRATVSPGRF--- HHHHHHCCCCCC---	19.79	29176673

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TM177_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TM177_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TM177_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TM177_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TM177_MOUSE

Related Literatures of Post-Translational Modification