FAF2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FAF2_MOUSE
• UniProt AC: Q3TDN2
• Protein Name: FAS-associated factor 2
• Gene Name: Faf2
• Organism: Mus musculus (Mouse).
• Sequence Length: 445
• Subcellular Localization: Cytoplasm . Lipid droplet . Endoplasmic reticulum .
• Protein Description: Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis..
• Protein Sequence: MAAPEEQDLTQEQTEKLLQFQDLTGIESMEQCRLALEQHNWNMEAAVQDRLNEQEGVPSVFNPPPARPLQVNTADHRIYSYVVSRPQPRGLLGWGYYLIMLPFRFTYYTILDIFRFALRFIRPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYSQALNDAKRELRFLLVYLHGDDHQDSDEFCRNALCAPEVISLINSRMLFWACSTNKPEGYRVSQALRENTYPFLAMIMLKDRRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSERLEREERNQTQVLRQQQDEAYLASLRADQEKERKKREEKERKRRKEEEVQQQKLAEERRRQNLQEEKERKLECLPPEPSPDDPESVKIIFKLPNDSRVERRFHFSQSLTVIHDFLFSLKESPEKFQIEANFPRRVLPCVPSEEWPNPPTLQEAGLSHTEVLFVQDLTDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAPEEQDL ------CCCHHHCCC	31.55	-
10	Phosphorylation	APEEQDLTQEQTEKL CHHHCCCCHHHHHHH	38.05	27841257
79	Phosphorylation	NTADHRIYSYVVSRP ECCCCEEEEEECCCC	8.23	25159016
80	Phosphorylation	TADHRIYSYVVSRPQ CCCCEEEEEECCCCC	14.74	25367039
124	Ubiquitination	ALRFIRPDPRSRVTD HHHHHCCCCCCCCCC	41.20	27667366
146	Ubiquitination	FMHSFEEKYGRAHPV HHHHHHHHHCCCCCE	45.89	-
162	Ubiquitination	YQGTYSQALNDAKRE ECCCHHHHHHHHHHH	11.46	27667366
167	Acetylation	SQALNDAKRELRFLL HHHHHHHHHHHHHEE	49.63	23954790
167	Ubiquitination	SQALNDAKRELRFLL HHHHHHHHHHHHHEE	49.63	-
167	Malonylation	SQALNDAKRELRFLL HHHHHHHHHHHHHEE	49.63	26320211
194	S-palmitoylation	EFCRNALCAPEVISL HHHHHCCCHHHHHHH	5.73	28526873
215	Acetylation	FWACSTNKPEGYRVS HHHHCCCCCCCCCHH	44.53	22826441
239	Acetylation	FLAMIMLKDRRMTVV EEEEEECCCCCEEEH	31.63	19852023
244	Phosphorylation	MLKDRRMTVVGRLEG ECCCCCEEEHHEHHC	15.38	19060867
297	Phosphorylation	RQQQDEAYLASLRAD HHHHCHHHHHHHHHH	10.76	25159016
301	Ubiquitination	DEAYLASLRADQEKE CHHHHHHHHHHHHHH	4.32	27667366
307	Ubiquitination	SLRADQEKERKKREE HHHHHHHHHHHHHHH	58.13	22790023
321	Ubiquitination	EKERKRRKEEEVQQQ HHHHHHHHHHHHHHH	73.78	-
329	Ubiquitination	EEEVQQQKLAEERRR HHHHHHHHHHHHHHH	45.38	22790023
339	Ubiquitination	EERRRQNLQEEKERK HHHHHHHHHHHHHHH	5.26	27667366
355	Phosphorylation	ECLPPEPSPDDPESV CCCCCCCCCCCHHHC	39.02	21930439
367	Malonylation	ESVKIIFKLPNDSRV HHCEEEEECCCCCCH	53.26	26320211
367	Ubiquitination	ESVKIIFKLPNDSRV HHCEEEEECCCCCCH	53.26	27667366
400	Ubiquitination	SLKESPEKFQIEANF HCCCCCCCCCEEECC	46.05	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FAF2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FAF2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FAF2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FAF2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.