XRP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: XRP2_MOUSE
• UniProt AC: Q9EPK2
• Protein Name: Protein XRP2
• Gene Name: Rp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 347
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cell projection, cilium . Detected predominantly at the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus.
• Protein Description: Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins..
• Protein Sequence: MGCCFTKRRKSEKAEGEEEQPKLYSWDQREKVDPKDYMFSGLKDETVGRLPGKVAGQQFVIQDCENCNIYIFDHSATITIDDCTNCVIFLGPVKGSVFFRNCRDCKCTLACQQFRVRDCRKLEVFLCCATQPIIESSTNIKFGCFQWYYPELAAQFKDAGLSIFNNIWSHVHDFTPVSGELNWSLLPENAVVQDYVPIPMTEEFKAVRISTEANRSIVPVSRGQRQKYSDESCLVVLFADDYTTANARKLIDEMVGKGFSLVQTKEMSMKTEDAQRVFQEKASDFLLLLNKGPVIALEFNGDDAVQECHLIVNGMFNGTKMFVSEKKETASGDVDSFYNFAEIQMGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGCCFTKRR ------CCCCCCCCC	19.53	-
3	S-palmitoylation	-----MGCCFTKRRK -----CCCCCCCCCC	1.34	-
13	Ubiquitination	TKRRKSEKAEGEEEQ CCCCCCCCCCCCCCC	59.85	27667366
22 (in isoform 2)	Ubiquitination	-	60.80	22790023
22	Ubiquitination	EGEEEQPKLYSWDQR CCCCCCCCCCCCHHH	60.80	22790023
24	Phosphorylation	EEEQPKLYSWDQREK CCCCCCCCCCHHHCC	17.53	29514104
25	Phosphorylation	EEQPKLYSWDQREKV CCCCCCCCCHHHCCC	34.31	25159016
35	Acetylation	QREKVDPKDYMFSGL HHCCCCHHHHCCCCC	57.96	7615243
43	Acetylation	DYMFSGLKDETVGRL HHCCCCCCCCCCCCC	57.98	7615253
111	S-palmitoylation	DCKCTLACQQFRVRD CCCCEEEEEEEECCC	3.53	28680068
211	Phosphorylation	FKAVRISTEANRSIV EEEEEEECCCCCCEE	36.42	21454597
216	Phosphorylation	ISTEANRSIVPVSRG EECCCCCCEEECCCC	27.95	23684622
221	Phosphorylation	NRSIVPVSRGQRQKY CCCEEECCCCCCCCC	25.32	23684622
228	Ubiquitination	SRGQRQKYSDESCLV CCCCCCCCCCCCEEE	17.02	27667366
260	Phosphorylation	EMVGKGFSLVQTKEM HHHHCCCEEEEEEEC	35.98	-
265	Ubiquitination	GFSLVQTKEMSMKTE CCEEEEEEECCCCHH	34.04	22790023
265 (in isoform 2)	Ubiquitination	-	34.04	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of XRP2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
2	G	Myristoylation	Myristoylated on Gly-2; which may be required for membrane targeting.	-
3	C	Palmitoylation	Palmitoylated on Cys-3; which may be required for plasma membrane targeting.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of XRP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of XRP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.