dbPTM

VTNC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VTNC_MOUSE
UniProt AC	P29788
Protein Name	Vitronectin
Gene Name	Vtn
Organism	Mus musculus (Mouse).
Sequence Length	478
Subcellular Localization	Secreted, extracellular space.
Protein Description	Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway..
Protein Sequence	MAPLRPFFILALVAWVSLADQESCKGRCTQGFMASKKCQCDELCTYYQSCCADYMEQCKPQVTRGDVFTMPEDDYWSYDYVEEPKNNTNTGVQPENTSPPGDLNPRTDGTLKPTAFLDPEEQPSTPAPKVEQQEEILRPDTTDQGTPEFPEEELCSGKPFDAFTDLKNGSLFAFRGQYCYELDETAVRPGYPKLIQDVWGIEGPIDAAFTRINCQGKTYLFKGSQYWRFEDGVLDPGYPRNISEGFSGIPDNVDAAFALPAHRYSGRERVYFFKGKQYWEYEFQQQPSQEECEGSSLSAVFEHFALLQRDSWENIFELLFWGRSSDGAREPQFISRNWHGVPGKVDAAMAGRIYVTGSLSHSAQAKKQKSKRRSRKRYRSRRGRGHRRSQSSNSRRSSRSIWFSLFSSEESGLGTYNNYDYDMDWLVPATCEPIQSVYFFSGDKYYRVNLRTRRVDSVNPPYPRSIAQYWLGCPTSEK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Phosphorylation	VTRGDVFTMPEDDYW CCCCCCEECCCCCCC	31.50	-
75	Sulfation	FTMPEDDYWSYDYVE EECCCCCCCCCCCEE	14.47	-
75	Sulfation	FTMPEDDYWSYDYVE EECCCCCCCCCCCEE	14.47	-
78	Sulfation	PEDDYWSYDYVEEPK CCCCCCCCCCEECCC	9.35	-
78	Sulfation	PEDDYWSYDYVEEPK CCCCCCCCCCEECCC	9.35	-
80	Sulfation	DDYWSYDYVEEPKNN CCCCCCCCEECCCCC	11.09	-
80	Sulfation	DDYWSYDYVEEPKNN CCCCCCCCEECCCCC	11.09	-
86	N-linked_Glycosylation	DYVEEPKNNTNTGVQ CCEECCCCCCCCCCC	71.87	-
98	Phosphorylation	GVQPENTSPPGDLNP CCCCCCCCCCCCCCC	40.45	29109428
168	N-linked_Glycosylation	DAFTDLKNGSLFAFR CCEEECCCCCEEEEE	53.21	-
222	Ubiquitination	QGKTYLFKGSQYWRF CCCEEEECCCEEEEE	55.87	22790023
241	N-linked_Glycosylation	LDPGYPRNISEGFSG CCCCCCCCCCCCCCC	37.32	17330941
278	Sulfation	YFFKGKQYWEYEFQQ EEEECCEEEEEEEEE	12.05	-
278	Sulfation	YFFKGKQYWEYEFQQ EEEECCEEEEEEEEE	12.05	-
281	Sulfation	KGKQYWEYEFQQQPS ECCEEEEEEEEECCC	14.11	-
281	Sulfation	KGKQYWEYEFQQQPS ECCEEEEEEEEECCC	14.11	-
311	Phosphorylation	FALLQRDSWENIFEL HHHHCCCCHHHHHHH	38.18	27180971
324	Phosphorylation	ELLFWGRSSDGAREP HHHHCCCCCCCCCCC	28.92	24719451
360	Phosphorylation	IYVTGSLSHSAQAKK EEEEECCCHHHHHHH	19.66	24719451
362	Phosphorylation	VTGSLSHSAQAKKQK EEECCCHHHHHHHHH	20.78	22817900
381	Methylation	SRKRYRSRRGRGHRR HHHHHHHHHCCCCCC	35.75	30989863
387	Methylation	SRRGRGHRRSQSSNS HHHCCCCCCCCCCCC	42.65	31199
388	Methylation	RRGRGHRRSQSSNSR HHCCCCCCCCCCCCC	33.11	30989875
394	Phosphorylation	RRSQSSNSRRSSRSI CCCCCCCCCCHHHHH	30.90	19854140
397	Phosphorylation	QSSNSRRSSRSIWFS CCCCCCCHHHHHHHH	29.06	19854140
398	Phosphorylation	SSNSRRSSRSIWFSL CCCCCCHHHHHHHHH	28.38	19854140
416	Sulfation	EESGLGTYNNYDYDM CCCCCCCCCCCCCCC	10.30	-
416	Sulfation	EESGLGTYNNYDYDM CCCCCCCCCCCCCCC	10.30	-
419	Sulfation	GLGTYNNYDYDMDWL CCCCCCCCCCCCCCE	16.55	-
419	Sulfation	GLGTYNNYDYDMDWL CCCCCCCCCCCCCCE	16.55	-
421	Sulfation	GTYNNYDYDMDWLVP CCCCCCCCCCCCEEE	11.65	-
421	Sulfation	GTYNNYDYDMDWLVP CCCCCCCCCCCCEEE	11.65	-
476	Phosphorylation	YWLGCPTSEK----- HHCCCCCCCC-----	28.65	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
398	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VTNC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VTNC_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of VTNC_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VTNC_MOUSE

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."; Bernhard O.K., Kapp E.A., Simpson R.J.; J. Proteome Res. 6:987-995(2007). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-241, AND MASSSPECTROMETRY.	17330941 [Abstract]