METK2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: METK2_MOUSE
• UniProt AC: Q3THS6
• Protein Name: S-adenosylmethionine synthase isoform type-2
• Gene Name: Mat2a
• Organism: Mus musculus (Mouse).
• Sequence Length: 395
• Protein Description: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate..
• Protein Sequence: MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Glutathionylation	DPDAKVACETVAKTG CCCCCHHHHHHHHHC	5.15	24333276
81	Ubiquitination	RAAIDYQKVVREAIK HHHCCHHHHHHHHHH	36.15	22790023
81	Acetylation	RAAIDYQKVVREAIK HHHCCHHHHHHHHHH	36.15	22826441
88	Acetylation	KVVREAIKHIGYDDS HHHHHHHHHHCCCCC	35.90	22826441
97	Ubiquitination	IGYDDSSKGFDYKTC HCCCCCCCCCCHHHH	68.50	22790023
97	Acetylation	IGYDDSSKGFDYKTC HCCCCCCCCCCHHHH	68.50	23864654
114	Phosphorylation	LVALEQQSPDIAQGV EEEEECCCCCHHHCE	25.00	-
228	Acetylation	ALKEKVIKAVVPAKY HHHHHHHHHHCCHHH	37.81	22826441
228	Ubiquitination	ALKEKVIKAVVPAKY HHHHHHHHHHCCHHH	37.81	22790023
234	Acetylation	IKAVVPAKYLDEDTI HHHHCCHHHCCCCCE	40.03	22826441
234	Ubiquitination	IKAVVPAKYLDEDTI HHHHCCHHHCCCCCE	40.03	22790023
265	Ubiquitination	DAGLTGRKIIVDTYG CCCCCCCEEEEECCC	37.82	-
285	Acetylation	GGGAFSGKDYTKVDR CCCCCCCCCCCCCCH	46.49	23954790
285	Ubiquitination	GGGAFSGKDYTKVDR CCCCCCCCCCCCCCH	46.49	-
296	Phosphorylation	KVDRSAAYAARWVAK CCCHHHHHHHHHHHH	10.66	-
303	Ubiquitination	YAARWVAKSLVKGGL HHHHHHHHHHHHCCC	34.40	-
350	Ubiquitination	RELLEIVKKNFDLRP HHHHHHHHHCCCCCC	47.89	22790023
351	Ubiquitination	ELLEIVKKNFDLRPG HHHHHHHHCCCCCCC	52.53	22790023
351	Acetylation	ELLEIVKKNFDLRPG HHHHHHHHCCCCCCC	52.53	22826441
367	Ubiquitination	IVRDLDLKKPIYQRT EEEECCCCCCHHHHH	57.05	22790023
374	Phosphorylation	KKPIYQRTAAYGHFG CCCHHHHHCCCCCCC	10.50	26745281
377	Phosphorylation	IYQRTAAYGHFGRDS HHHHHCCCCCCCCCC	14.52	26745281
384	Phosphorylation	YGHFGRDSFPWEVPK CCCCCCCCCCCCCCC	31.67	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of METK2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of METK2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of METK2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUV91_MOUSE	Suv39h1	physical	23539621

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.