ACAD9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACAD9_MOUSE
• UniProt AC: Q8JZN5
• Protein Name: Acyl-CoA dehydrogenase family member 9, mitochondrial
• Gene Name: Acad9
• Organism: Mus musculus (Mouse).
• Sequence Length: 625
• Subcellular Localization: Mitochondrion .
• Protein Description: Required for mitochondrial complex I assembly (By similarity). Has a dehydrogenase activity on palmitoyl-CoA (C16:0) and stearoyl-CoA (C18:0). It is three times more active on palmitoyl-CoA then on stearoyl-CoA. However, it does not play a primary role in long-chain fatty acid oxidation (By similarity). Has little activity on octanoyl-CoA (C8:0), butyryl-CoA (C4:0) or isovaleryl-CoA (5:0) (By similarity)..
• Protein Sequence: MSGCVLLSRGATAAAAAARASRVLREFTARRRPLHTSLQSCSFAKELFLGNIEQKGVFPFPEVSQHELSEINQFVGPLEKFFTEEVDSRKIDQEGKIPVDTLEKLKSLGLFGIQVPEEYGGLGLSNTMYARLGEIISLDASITVTLAAHQAIGLKGIILVGNEEQKAKYLPKLSSGEHIAAFCLTEPASGSDAASIQTRATLSEDKKYFILNGSKVWITNGGLANIFTVFAKTEVVDSDGSKTDKMTAFIVERDFGGITNGKPEDKLGIRGSNTCEVHFENTRVPVENVLGEVGGGFKVAMNILNSGRFSMGSAVAGMLKKLIELTAEYACTRKQFNRNLSEFGLIQEKFALMAQKAYVMESMAYLTSGMLDQPGFPDCSIEAAMVKVFSSEAAWQCVSEALQILGGSGYMKDYPYERMLRDARILLIFEGTNEILRLFIALTGLQHAGRILTSRIKELKSGNVTTVMETIGRKLRDSLGRTVDLGLTGDLGVVHPSLGDSANKLEENVHYFGRTVETLLLRFGKNIVEEQLVLKRVANILINLYGMTAVLSRASRSIRIGLRNHDHEVLLANMFCVEAYFQNLFSLSQLDKNAPENLDEQIKKVSRQILEKRAYICAHPLDRAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	AAAAARASRVLREFT HHHHHHHHHHHHHHH	19.85	28059163
45	Acetylation	LQSCSFAKELFLGNI HHHCHHHHHHHCCCC	53.60	23576753
55	Acetylation	FLGNIEQKGVFPFPE HCCCCCCCCCCCCCC	44.23	23954790
96	Succinylation	RKIDQEGKIPVDTLE CCCCCCCCCCHHHHH	42.98	23806337
96	Acetylation	RKIDQEGKIPVDTLE CCCCCCCCCCHHHHH	42.98	23806337
96	Succinylation	RKIDQEGKIPVDTLE CCCCCCCCCCHHHHH	42.98	-
104	Succinylation	IPVDTLEKLKSLGLF CCHHHHHHHHHCCCC	65.41	23806337
104	Acetylation	IPVDTLEKLKSLGLF CCHHHHHHHHHCCCC	65.41	23806337
183	S-nitrosylation	GEHIAAFCLTEPASG CCEEEEEEECCCCCC	3.84	21278135
183	S-nitrosocysteine	GEHIAAFCLTEPASG CCEEEEEEECCCCCC	3.84	-
206	Acetylation	RATLSEDKKYFILNG CCCCCCCCCEEEECC	45.37	23864654
241	Phosphorylation	EVVDSDGSKTDKMTA EEECCCCCCCCCEEE	37.06	28059163
242	Succinylation	VVDSDGSKTDKMTAF EECCCCCCCCCEEEE	67.29	23806337
242	Succinylation	VVDSDGSKTDKMTAF EECCCCCCCCCEEEE	67.29	-
242	Acetylation	VVDSDGSKTDKMTAF EECCCCCCCCCEEEE	67.29	23806337
245	Acetylation	SDGSKTDKMTAFIVE CCCCCCCCEEEEEEE	43.30	23201123
262	Acetylation	FGGITNGKPEDKLGI CCCCCCCCCCCCCCC	47.51	23954790
262	Succinylation	FGGITNGKPEDKLGI CCCCCCCCCCCCCCC	47.51	23954790
275	S-nitrosocysteine	GIRGSNTCEVHFENT CCCCCCEEEEEECCC	6.34	-
275	S-nitrosylation	GIRGSNTCEVHFENT CCCCCCEEEEEECCC	6.34	21278135
331	S-nitrosylation	ELTAEYACTRKQFNR HHHHHHHHHHHHHHC	3.56	22178444
453	Phosphorylation	QHAGRILTSRIKELK HHHHHHHHHHHHHHH	17.37	24719451
478	Phosphorylation	IGRKLRDSLGRTVDL HHHHHHHHHCCCCCC	26.70	9521093
482	Phosphorylation	LRDSLGRTVDLGLTG HHHHHCCCCCCCCCC	19.30	27180971
488	Phosphorylation	RTVDLGLTGDLGVVH CCCCCCCCCCEEECC	27.18	22817900
525	Succinylation	TLLLRFGKNIVEEQL HHHHHHCCCHHHHHH	40.57	23806337
525	Succinylation	TLLLRFGKNIVEEQL HHHHHHCCCHHHHHH	40.57	-
525	Acetylation	TLLLRFGKNIVEEQL HHHHHHCCCHHHHHH	40.57	23576753
606	Phosphorylation	DEQIKKVSRQILEKR HHHHHHHHHHHHHHH	27.61	22324799
612	Acetylation	VSRQILEKRAYICAH HHHHHHHHHCCCCCC	38.59	23864654
617	S-nitrosocysteine	LEKRAYICAHPLDRA HHHHCCCCCCCCCCC	1.53	-
617	Glutathionylation	LEKRAYICAHPLDRA HHHHCCCCCCCCCCC	1.53	24333276
617	S-nitrosylation	LEKRAYICAHPLDRA HHHHCCCCCCCCCCC	1.53	22178444

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACAD9_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACAD9_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACAD9_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ACAD9_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.