UniProt ID | VWA8_MOUSE | |
---|---|---|
UniProt AC | Q8CC88 | |
Protein Name | von Willebrand factor A domain-containing protein 8 | |
Gene Name | Vwa8 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 1905 | |
Subcellular Localization | Mitochondrion . | |
Protein Description | Exhibits ATPase activity in vitro.. | |
Protein Sequence | MQSRLLLLGAPGGLGDVASRRVRLLLRQVLRGRPGGDQQRLEVRLLHSGATDSGETVSIGDVSYKLKTPKNPELVPQNYISDSPAQSIVQHLRWLMQKDLLGQDVFLIGPPGPLRRSVAMQYLELTKREVEYIALSRDTTETDLKQRREIRAGTAFYIDQCAVRAATEGRTLVLEGLEKAERNVLPVLNNLLENREMQLEDGRFLMSAERYDKLLQDHTKEELDAWKIVRVSENFRVIALGLPVPRYSGNPLDPPLRSRFQARDIYFLPFQDQLKLLYSVGANVSAEKISQLLSFATTLCSQESSTLGLPDFPLDSLPEAVQILDSFPMMSIEHALQWVYPYTLLLGHEGKMAVEGVLKRFELQGSGHSLLPKEIVRVERMTDSHGSYAHVTIRVAGKEVTIKVPAGTRAVNQPCAPDHFIQTVSHKQLLAEMVQSHMVKDICLIGGKGCGKTVIAKNFAALLGYSIEPIMLYQDMTARDLLQQRYTLPNGDTAWRSSPLVSAAREGKLVLLDGIHRVNAGTLAVLQRLIHDRELSLYDGSRLLREDRYLSLKEKLQLTDEQLQNRSIFPIHPSFRIIALAEPPIVGSTTQQWLGPEFLTMFFFHHMKPLVKSEEIQVIKETVPNVPQEALEKLLSVTHKLRETQDPTAQSLAASLSTRQLLRISRRLSKYPSENLHDAITKACLSRFLPSLAQSALEKNLADAAIETNTEDSLEPELENYKCEVVAGSLKIGAVSVPVHNAHEKMKVPDVLFYDNVQHMVVMEDMLKDFVLGEHLLLVGNQGVGKNKIVDRFLHLLNRPREYIQLHRDTTVQSLTLQPTVKGGLIVYEDSPLVKAVKLGHILVVDEADKAPTNVTCILKTLVENGEMILADGRRIVADAANVDGRENLVAIHPDFRMLALANRPGFPFLGNDFFGTLGDIFSCHAIDNPKPHSELSMLKQYGPDVPEPVLQKLVAAFGELRNLADQGIINYPYSTREVVNIVKHLQKFPTEGLSSVVRNVFDFDSYNNDMREILMNTLHKYGIPIGAKPTNVQLAKEFPLPEKTFMGYWIVGQTGNGMQKVLCPAETNHVDIKGPVLVNMEKYPIEKHEARFLSFTEECTSWKFPLDEVNLICDIAVSHENGEQTLYVAACNPVSLYFMNMTGKNGFFVDFFDIFPRMASGSWRPFVTVAPLGSPLRGQVVLHEEQSNAVLLLDTTGSAIRRLVLPTEEFTSKKSSWWSKEEGETYRMCKEFSHKNWVVFYKQTGNSLTVLDVLEGLAHTISLPINLRTVFLVAEDKWLLVENETNQKYLLTKPAHIGSEDTGACQLYMLKEELPSTGFGVTQETEFCIPDKVSSDQLSSENLTSAVGQKIASPNRILSDENSHATIVVGFPDLMSPSEVYSWKRSSSLRQPSVTSMTMYTGKRTNATPRHNNCVTLTHTNQVVRILPPGEVPLKDLYPKDVTPPQTAGYIEVTDLQAKKLRYIPVPSAESLSPYTAWISAISDTDALLAEWDKSSVVTVDMGGRVRLWETGLERLQQSLMEWRNMIGQDSDKHVQITIERDSNEDVSDPKHGKEDPDNMPHVGGNTWAGGTGGRDTAGLGGKGGPYRLDAGHPVYQVSEVEKDAVPEDVKRAAREMAQKAFQQRLKEIQMSEYDAATYERFSSAVQRQVHALRIILDNLQAKGKERQWLRHQATGELDDAKIIDGLAGEKSIYKRRGDLEPQLGSPQQKPKRLRLVVDVSGSMYRFNGVDRRLERSMEAVCMVMEAFENYEEKFKYDIAGHSGDGYNIKLVPVNQIPKNNKQRLEILKTMHEHSQFCMSGDHTLEGTEHAIKDITTEEADEYFVIILSDANLSRYGINPARFAQILTSDPQVNAFAIFIGSLGDQAARLQRTLPAGRSFIAMDTKKIPQILQQIFTSTMLSSI | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
145 | Ubiquitination | DTTETDLKQRREIRA CCCCCHHHHHHHHHC | 27667366 | ||
161 | S-nitrosocysteine | TAFYIDQCAVRAATE CEEEEEHHHHHHHHC | - | ||
171 | Phosphorylation | RAATEGRTLVLEGLE HHHHCCCEEEEHHHH | 24719451 | ||
220 | Acetylation | KLLQDHTKEELDAWK HHHHHCCHHHHHHHE | 23864654 | ||
220 (in isoform 2) | Acetylation | - | - | ||
227 | Acetylation | KEELDAWKIVRVSEN HHHHHHHEEEEECCC | 23954790 | ||
227 | Succinylation | KEELDAWKIVRVSEN HHHHHHHEEEEECCC | 23954790 | ||
359 | Acetylation | MAVEGVLKRFELQGS HHHHHHHHHEEECCC | 23576753 | ||
453 | Phosphorylation | GGKGCGKTVIAKNFA CCCCCCHHHHHHHHH | 23926118 | ||
508 (in isoform 2) | Acetylation | - | - | ||
508 | Acetylation | VSAAREGKLVLLDGI HHHHHCCCEEEEECC | 23201123 | ||
555 | Ubiquitination | RYLSLKEKLQLTDEQ CCCCHHHHHCCCHHH | 22790023 | ||
612 | Succinylation | HHMKPLVKSEEIQVI HHCCCCCCHHHHHHH | 23954790 | ||
620 | Succinylation | SEEIQVIKETVPNVP HHHHHHHHHHCCCCC | 23954790 | ||
633 | Acetylation | VPQEALEKLLSVTHK CCHHHHHHHHHHHHH | 23954790 | ||
670 (in isoform 2) | Acetylation | - | - | ||
670 | Acetylation | RISRRLSKYPSENLH HHHHHHHCCCCCCHH | 23201123 | ||
699 | Acetylation | LAQSALEKNLADAAI HHHHHHHHHHHHHHH | 23954790 | ||
857 | S-nitrosocysteine | KAPTNVTCILKTLVE CCCCCEEEEEEHHHH | - | ||
953 | Acetylation | VPEPVLQKLVAAFGE CCHHHHHHHHHHHHH | 23954790 | ||
988 | Ubiquitination | NIVKHLQKFPTEGLS HHHHHHHHCCCCCHH | 22790023 | ||
988 | Acetylation | NIVKHLQKFPTEGLS HHHHHHHHCCCCCHH | 23864654 | ||
988 (in isoform 2) | Acetylation | - | - | ||
1029 | Acetylation | YGIPIGAKPTNVQLA HCCCCCCCCCCCCCC | 23954790 | ||
1037 (in isoform 2) | Acetylation | - | - | ||
1037 | Acetylation | PTNVQLAKEFPLPEK CCCCCCCCCCCCCCC | 23201123 | ||
1045 | Phosphorylation | EFPLPEKTFMGYWIV CCCCCCCEEEEEEEE | 20469934 | ||
1064 | S-nitrosocysteine | NGMQKVLCPAETNHV CCCEEEECCCCCCCC | - | ||
1074 | Acetylation | ETNHVDIKGPVLVNM CCCCCCCCCCEEECC | 23864654 | ||
1083 | Acetylation | PVLVNMEKYPIEKHE CEEECCEECCCCCHH | 23201123 | ||
1083 | Ubiquitination | PVLVNMEKYPIEKHE CEEECCEECCCCCHH | 22790023 | ||
1095 | Phosphorylation | KHEARFLSFTEECTS CHHHHEECCCCCHHC | 25338131 | ||
1175 | Phosphorylation | VTVAPLGSPLRGQVV EEEEECCCCCCCEEE | 27149854 | ||
1221 | Acetylation | KKSSWWSKEEGETYR CCCCCCCHHCCCCCE | 23954790 | ||
1317 | Phosphorylation | MLKEELPSTGFGVTQ EEECCCCCCCCCCCC | 23140645 | ||
1318 | Phosphorylation | LKEELPSTGFGVTQE EECCCCCCCCCCCCC | 23140645 | ||
1323 | Phosphorylation | PSTGFGVTQETEFCI CCCCCCCCCCEEEEC | 23140645 | ||
1326 | Phosphorylation | GFGVTQETEFCIPDK CCCCCCCEEEECCCC | 23140645 | ||
1351 | Acetylation | LTSAVGQKIASPNRI HHHHHHHHCCCCCCC | 23864654 | ||
1360 | Phosphorylation | ASPNRILSDENSHAT CCCCCCCCCCCCCCE | 30635358 | ||
1364 | Phosphorylation | RILSDENSHATIVVG CCCCCCCCCCEEEEC | 30635358 | ||
1367 | Phosphorylation | SDENSHATIVVGFPD CCCCCCCEEEECCCC | 30635358 | ||
1377 | Phosphorylation | VGFPDLMSPSEVYSW ECCCCCCCHHHHHCC | 30635358 | ||
1379 | Phosphorylation | FPDLMSPSEVYSWKR CCCCCCHHHHHCCCC | 30635358 | ||
1382 | Phosphorylation | LMSPSEVYSWKRSSS CCCHHHHHCCCCCCC | 30635358 | ||
1383 | Phosphorylation | MSPSEVYSWKRSSSL CCHHHHHCCCCCCCC | 30635358 | ||
1396 | Phosphorylation | SLRQPSVTSMTMYTG CCCCCCCCEEEEECC | 20139300 | ||
1399 | Phosphorylation | QPSVTSMTMYTGKRT CCCCCEEEEECCCCC | 20139300 | ||
1401 | Phosphorylation | SVTSMTMYTGKRTNA CCCEEEEECCCCCCC | 20139300 | ||
1415 | S-nitrosocysteine | ATPRHNNCVTLTHTN CCCCCCCCEEEEECC | - | ||
1539 | Phosphorylation | SDKHVQITIERDSNE CCCCEEEEEECCCCC | 28973931 | ||
1544 | Phosphorylation | QITIERDSNEDVSDP EEEEECCCCCCCCCC | 21659604 | ||
1584 | Ubiquitination | DTAGLGGKGGPYRLD CCCCCCCCCCCCCCC | 22790023 | ||
1597 | Phosphorylation | LDAGHPVYQVSEVEK CCCCCCEEEEECCCC | 23140645 | ||
1600 | Phosphorylation | GHPVYQVSEVEKDAV CCCEEEEECCCCCCC | 23140645 | ||
1612 | Acetylation | DAVPEDVKRAAREMA CCCCHHHHHHHHHHH | 2393719 | ||
1628 | Ubiquitination | KAFQQRLKEIQMSEY HHHHHHHHHHHCCCC | 22790023 | ||
1707 | Phosphorylation | DLEPQLGSPQQKPKR CCCCCCCCCCCCCCC | 20469934 | ||
1757 | Acetylation | ENYEEKFKYDIAGHS HCHHHHHCCEECCCC | 23201123 | ||
1874 | Phosphorylation | QAARLQRTLPAGRSF HHHHHHHHCCCCCCE | - | ||
1887 | Succinylation | SFIAMDTKKIPQILQ CEEEECCCHHHHHHH | 23954790 | ||
1887 | Acetylation | SFIAMDTKKIPQILQ CEEEECCCHHHHHHH | 23954790 | ||
1888 | Acetylation | FIAMDTKKIPQILQQ EEEECCCHHHHHHHH | 2415387 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VWA8_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VWA8_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VWA8_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of VWA8_MOUSE !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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