| UniProt ID | VWA8_MOUSE | |
|---|---|---|
| UniProt AC | Q8CC88 | |
| Protein Name | von Willebrand factor A domain-containing protein 8 | |
| Gene Name | Vwa8 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1905 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | Exhibits ATPase activity in vitro.. | |
| Protein Sequence | MQSRLLLLGAPGGLGDVASRRVRLLLRQVLRGRPGGDQQRLEVRLLHSGATDSGETVSIGDVSYKLKTPKNPELVPQNYISDSPAQSIVQHLRWLMQKDLLGQDVFLIGPPGPLRRSVAMQYLELTKREVEYIALSRDTTETDLKQRREIRAGTAFYIDQCAVRAATEGRTLVLEGLEKAERNVLPVLNNLLENREMQLEDGRFLMSAERYDKLLQDHTKEELDAWKIVRVSENFRVIALGLPVPRYSGNPLDPPLRSRFQARDIYFLPFQDQLKLLYSVGANVSAEKISQLLSFATTLCSQESSTLGLPDFPLDSLPEAVQILDSFPMMSIEHALQWVYPYTLLLGHEGKMAVEGVLKRFELQGSGHSLLPKEIVRVERMTDSHGSYAHVTIRVAGKEVTIKVPAGTRAVNQPCAPDHFIQTVSHKQLLAEMVQSHMVKDICLIGGKGCGKTVIAKNFAALLGYSIEPIMLYQDMTARDLLQQRYTLPNGDTAWRSSPLVSAAREGKLVLLDGIHRVNAGTLAVLQRLIHDRELSLYDGSRLLREDRYLSLKEKLQLTDEQLQNRSIFPIHPSFRIIALAEPPIVGSTTQQWLGPEFLTMFFFHHMKPLVKSEEIQVIKETVPNVPQEALEKLLSVTHKLRETQDPTAQSLAASLSTRQLLRISRRLSKYPSENLHDAITKACLSRFLPSLAQSALEKNLADAAIETNTEDSLEPELENYKCEVVAGSLKIGAVSVPVHNAHEKMKVPDVLFYDNVQHMVVMEDMLKDFVLGEHLLLVGNQGVGKNKIVDRFLHLLNRPREYIQLHRDTTVQSLTLQPTVKGGLIVYEDSPLVKAVKLGHILVVDEADKAPTNVTCILKTLVENGEMILADGRRIVADAANVDGRENLVAIHPDFRMLALANRPGFPFLGNDFFGTLGDIFSCHAIDNPKPHSELSMLKQYGPDVPEPVLQKLVAAFGELRNLADQGIINYPYSTREVVNIVKHLQKFPTEGLSSVVRNVFDFDSYNNDMREILMNTLHKYGIPIGAKPTNVQLAKEFPLPEKTFMGYWIVGQTGNGMQKVLCPAETNHVDIKGPVLVNMEKYPIEKHEARFLSFTEECTSWKFPLDEVNLICDIAVSHENGEQTLYVAACNPVSLYFMNMTGKNGFFVDFFDIFPRMASGSWRPFVTVAPLGSPLRGQVVLHEEQSNAVLLLDTTGSAIRRLVLPTEEFTSKKSSWWSKEEGETYRMCKEFSHKNWVVFYKQTGNSLTVLDVLEGLAHTISLPINLRTVFLVAEDKWLLVENETNQKYLLTKPAHIGSEDTGACQLYMLKEELPSTGFGVTQETEFCIPDKVSSDQLSSENLTSAVGQKIASPNRILSDENSHATIVVGFPDLMSPSEVYSWKRSSSLRQPSVTSMTMYTGKRTNATPRHNNCVTLTHTNQVVRILPPGEVPLKDLYPKDVTPPQTAGYIEVTDLQAKKLRYIPVPSAESLSPYTAWISAISDTDALLAEWDKSSVVTVDMGGRVRLWETGLERLQQSLMEWRNMIGQDSDKHVQITIERDSNEDVSDPKHGKEDPDNMPHVGGNTWAGGTGGRDTAGLGGKGGPYRLDAGHPVYQVSEVEKDAVPEDVKRAAREMAQKAFQQRLKEIQMSEYDAATYERFSSAVQRQVHALRIILDNLQAKGKERQWLRHQATGELDDAKIIDGLAGEKSIYKRRGDLEPQLGSPQQKPKRLRLVVDVSGSMYRFNGVDRRLERSMEAVCMVMEAFENYEEKFKYDIAGHSGDGYNIKLVPVNQIPKNNKQRLEILKTMHEHSQFCMSGDHTLEGTEHAIKDITTEEADEYFVIILSDANLSRYGINPARFAQILTSDPQVNAFAIFIGSLGDQAARLQRTLPAGRSFIAMDTKKIPQILQQIFTSTMLSSI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 145 | Ubiquitination | DTTETDLKQRREIRA CCCCCHHHHHHHHHC | 27667366 | ||
| 161 | S-nitrosocysteine | TAFYIDQCAVRAATE CEEEEEHHHHHHHHC | - | ||
| 171 | Phosphorylation | RAATEGRTLVLEGLE HHHHCCCEEEEHHHH | 24719451 | ||
| 220 | Acetylation | KLLQDHTKEELDAWK HHHHHCCHHHHHHHE | 23864654 | ||
| 220 (in isoform 2) | Acetylation | - | - | ||
| 227 | Acetylation | KEELDAWKIVRVSEN HHHHHHHEEEEECCC | 23954790 | ||
| 227 | Succinylation | KEELDAWKIVRVSEN HHHHHHHEEEEECCC | 23954790 | ||
| 359 | Acetylation | MAVEGVLKRFELQGS HHHHHHHHHEEECCC | 23576753 | ||
| 453 | Phosphorylation | GGKGCGKTVIAKNFA CCCCCCHHHHHHHHH | 23926118 | ||
| 508 (in isoform 2) | Acetylation | - | - | ||
| 508 | Acetylation | VSAAREGKLVLLDGI HHHHHCCCEEEEECC | 23201123 | ||
| 555 | Ubiquitination | RYLSLKEKLQLTDEQ CCCCHHHHHCCCHHH | 22790023 | ||
| 612 | Succinylation | HHMKPLVKSEEIQVI HHCCCCCCHHHHHHH | 23954790 | ||
| 620 | Succinylation | SEEIQVIKETVPNVP HHHHHHHHHHCCCCC | 23954790 | ||
| 633 | Acetylation | VPQEALEKLLSVTHK CCHHHHHHHHHHHHH | 23954790 | ||
| 670 (in isoform 2) | Acetylation | - | - | ||
| 670 | Acetylation | RISRRLSKYPSENLH HHHHHHHCCCCCCHH | 23201123 | ||
| 699 | Acetylation | LAQSALEKNLADAAI HHHHHHHHHHHHHHH | 23954790 | ||
| 857 | S-nitrosocysteine | KAPTNVTCILKTLVE CCCCCEEEEEEHHHH | - | ||
| 953 | Acetylation | VPEPVLQKLVAAFGE CCHHHHHHHHHHHHH | 23954790 | ||
| 988 | Ubiquitination | NIVKHLQKFPTEGLS HHHHHHHHCCCCCHH | 22790023 | ||
| 988 | Acetylation | NIVKHLQKFPTEGLS HHHHHHHHCCCCCHH | 23864654 | ||
| 988 (in isoform 2) | Acetylation | - | - | ||
| 1029 | Acetylation | YGIPIGAKPTNVQLA HCCCCCCCCCCCCCC | 23954790 | ||
| 1037 (in isoform 2) | Acetylation | - | - | ||
| 1037 | Acetylation | PTNVQLAKEFPLPEK CCCCCCCCCCCCCCC | 23201123 | ||
| 1045 | Phosphorylation | EFPLPEKTFMGYWIV CCCCCCCEEEEEEEE | 20469934 | ||
| 1064 | S-nitrosocysteine | NGMQKVLCPAETNHV CCCEEEECCCCCCCC | - | ||
| 1074 | Acetylation | ETNHVDIKGPVLVNM CCCCCCCCCCEEECC | 23864654 | ||
| 1083 | Acetylation | PVLVNMEKYPIEKHE CEEECCEECCCCCHH | 23201123 | ||
| 1083 | Ubiquitination | PVLVNMEKYPIEKHE CEEECCEECCCCCHH | 22790023 | ||
| 1095 | Phosphorylation | KHEARFLSFTEECTS CHHHHEECCCCCHHC | 25338131 | ||
| 1175 | Phosphorylation | VTVAPLGSPLRGQVV EEEEECCCCCCCEEE | 27149854 | ||
| 1221 | Acetylation | KKSSWWSKEEGETYR CCCCCCCHHCCCCCE | 23954790 | ||
| 1317 | Phosphorylation | MLKEELPSTGFGVTQ EEECCCCCCCCCCCC | 23140645 | ||
| 1318 | Phosphorylation | LKEELPSTGFGVTQE EECCCCCCCCCCCCC | 23140645 | ||
| 1323 | Phosphorylation | PSTGFGVTQETEFCI CCCCCCCCCCEEEEC | 23140645 | ||
| 1326 | Phosphorylation | GFGVTQETEFCIPDK CCCCCCCEEEECCCC | 23140645 | ||
| 1351 | Acetylation | LTSAVGQKIASPNRI HHHHHHHHCCCCCCC | 23864654 | ||
| 1360 | Phosphorylation | ASPNRILSDENSHAT CCCCCCCCCCCCCCE | 30635358 | ||
| 1364 | Phosphorylation | RILSDENSHATIVVG CCCCCCCCCCEEEEC | 30635358 | ||
| 1367 | Phosphorylation | SDENSHATIVVGFPD CCCCCCCEEEECCCC | 30635358 | ||
| 1377 | Phosphorylation | VGFPDLMSPSEVYSW ECCCCCCCHHHHHCC | 30635358 | ||
| 1379 | Phosphorylation | FPDLMSPSEVYSWKR CCCCCCHHHHHCCCC | 30635358 | ||
| 1382 | Phosphorylation | LMSPSEVYSWKRSSS CCCHHHHHCCCCCCC | 30635358 | ||
| 1383 | Phosphorylation | MSPSEVYSWKRSSSL CCHHHHHCCCCCCCC | 30635358 | ||
| 1396 | Phosphorylation | SLRQPSVTSMTMYTG CCCCCCCCEEEEECC | 20139300 | ||
| 1399 | Phosphorylation | QPSVTSMTMYTGKRT CCCCCEEEEECCCCC | 20139300 | ||
| 1401 | Phosphorylation | SVTSMTMYTGKRTNA CCCEEEEECCCCCCC | 20139300 | ||
| 1415 | S-nitrosocysteine | ATPRHNNCVTLTHTN CCCCCCCCEEEEECC | - | ||
| 1539 | Phosphorylation | SDKHVQITIERDSNE CCCCEEEEEECCCCC | 28973931 | ||
| 1544 | Phosphorylation | QITIERDSNEDVSDP EEEEECCCCCCCCCC | 21659604 | ||
| 1584 | Ubiquitination | DTAGLGGKGGPYRLD CCCCCCCCCCCCCCC | 22790023 | ||
| 1597 | Phosphorylation | LDAGHPVYQVSEVEK CCCCCCEEEEECCCC | 23140645 | ||
| 1600 | Phosphorylation | GHPVYQVSEVEKDAV CCCEEEEECCCCCCC | 23140645 | ||
| 1612 | Acetylation | DAVPEDVKRAAREMA CCCCHHHHHHHHHHH | 2393719 | ||
| 1628 | Ubiquitination | KAFQQRLKEIQMSEY HHHHHHHHHHHCCCC | 22790023 | ||
| 1707 | Phosphorylation | DLEPQLGSPQQKPKR CCCCCCCCCCCCCCC | 20469934 | ||
| 1757 | Acetylation | ENYEEKFKYDIAGHS HCHHHHHCCEECCCC | 23201123 | ||
| 1874 | Phosphorylation | QAARLQRTLPAGRSF HHHHHHHHCCCCCCE | - | ||
| 1887 | Succinylation | SFIAMDTKKIPQILQ CEEEECCCHHHHHHH | 23954790 | ||
| 1887 | Acetylation | SFIAMDTKKIPQILQ CEEEECCCHHHHHHH | 23954790 | ||
| 1888 | Acetylation | FIAMDTKKIPQILQQ EEEECCCHHHHHHHH | 2415387 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VWA8_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VWA8_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VWA8_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of VWA8_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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