VWA8_MOUSE - dbPTM
VWA8_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VWA8_MOUSE
UniProt AC Q8CC88
Protein Name von Willebrand factor A domain-containing protein 8
Gene Name Vwa8
Organism Mus musculus (Mouse).
Sequence Length 1905
Subcellular Localization Mitochondrion .
Protein Description Exhibits ATPase activity in vitro..
Protein Sequence MQSRLLLLGAPGGLGDVASRRVRLLLRQVLRGRPGGDQQRLEVRLLHSGATDSGETVSIGDVSYKLKTPKNPELVPQNYISDSPAQSIVQHLRWLMQKDLLGQDVFLIGPPGPLRRSVAMQYLELTKREVEYIALSRDTTETDLKQRREIRAGTAFYIDQCAVRAATEGRTLVLEGLEKAERNVLPVLNNLLENREMQLEDGRFLMSAERYDKLLQDHTKEELDAWKIVRVSENFRVIALGLPVPRYSGNPLDPPLRSRFQARDIYFLPFQDQLKLLYSVGANVSAEKISQLLSFATTLCSQESSTLGLPDFPLDSLPEAVQILDSFPMMSIEHALQWVYPYTLLLGHEGKMAVEGVLKRFELQGSGHSLLPKEIVRVERMTDSHGSYAHVTIRVAGKEVTIKVPAGTRAVNQPCAPDHFIQTVSHKQLLAEMVQSHMVKDICLIGGKGCGKTVIAKNFAALLGYSIEPIMLYQDMTARDLLQQRYTLPNGDTAWRSSPLVSAAREGKLVLLDGIHRVNAGTLAVLQRLIHDRELSLYDGSRLLREDRYLSLKEKLQLTDEQLQNRSIFPIHPSFRIIALAEPPIVGSTTQQWLGPEFLTMFFFHHMKPLVKSEEIQVIKETVPNVPQEALEKLLSVTHKLRETQDPTAQSLAASLSTRQLLRISRRLSKYPSENLHDAITKACLSRFLPSLAQSALEKNLADAAIETNTEDSLEPELENYKCEVVAGSLKIGAVSVPVHNAHEKMKVPDVLFYDNVQHMVVMEDMLKDFVLGEHLLLVGNQGVGKNKIVDRFLHLLNRPREYIQLHRDTTVQSLTLQPTVKGGLIVYEDSPLVKAVKLGHILVVDEADKAPTNVTCILKTLVENGEMILADGRRIVADAANVDGRENLVAIHPDFRMLALANRPGFPFLGNDFFGTLGDIFSCHAIDNPKPHSELSMLKQYGPDVPEPVLQKLVAAFGELRNLADQGIINYPYSTREVVNIVKHLQKFPTEGLSSVVRNVFDFDSYNNDMREILMNTLHKYGIPIGAKPTNVQLAKEFPLPEKTFMGYWIVGQTGNGMQKVLCPAETNHVDIKGPVLVNMEKYPIEKHEARFLSFTEECTSWKFPLDEVNLICDIAVSHENGEQTLYVAACNPVSLYFMNMTGKNGFFVDFFDIFPRMASGSWRPFVTVAPLGSPLRGQVVLHEEQSNAVLLLDTTGSAIRRLVLPTEEFTSKKSSWWSKEEGETYRMCKEFSHKNWVVFYKQTGNSLTVLDVLEGLAHTISLPINLRTVFLVAEDKWLLVENETNQKYLLTKPAHIGSEDTGACQLYMLKEELPSTGFGVTQETEFCIPDKVSSDQLSSENLTSAVGQKIASPNRILSDENSHATIVVGFPDLMSPSEVYSWKRSSSLRQPSVTSMTMYTGKRTNATPRHNNCVTLTHTNQVVRILPPGEVPLKDLYPKDVTPPQTAGYIEVTDLQAKKLRYIPVPSAESLSPYTAWISAISDTDALLAEWDKSSVVTVDMGGRVRLWETGLERLQQSLMEWRNMIGQDSDKHVQITIERDSNEDVSDPKHGKEDPDNMPHVGGNTWAGGTGGRDTAGLGGKGGPYRLDAGHPVYQVSEVEKDAVPEDVKRAAREMAQKAFQQRLKEIQMSEYDAATYERFSSAVQRQVHALRIILDNLQAKGKERQWLRHQATGELDDAKIIDGLAGEKSIYKRRGDLEPQLGSPQQKPKRLRLVVDVSGSMYRFNGVDRRLERSMEAVCMVMEAFENYEEKFKYDIAGHSGDGYNIKLVPVNQIPKNNKQRLEILKTMHEHSQFCMSGDHTLEGTEHAIKDITTEEADEYFVIILSDANLSRYGINPARFAQILTSDPQVNAFAIFIGSLGDQAARLQRTLPAGRSFIAMDTKKIPQILQQIFTSTMLSSI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
145UbiquitinationDTTETDLKQRREIRA
CCCCCHHHHHHHHHC
27667366
161S-nitrosocysteineTAFYIDQCAVRAATE
CEEEEEHHHHHHHHC
-
171PhosphorylationRAATEGRTLVLEGLE
HHHHCCCEEEEHHHH
24719451
220AcetylationKLLQDHTKEELDAWK
HHHHHCCHHHHHHHE
23864654
220 (in isoform 2)Acetylation--
227AcetylationKEELDAWKIVRVSEN
HHHHHHHEEEEECCC
23954790
227SuccinylationKEELDAWKIVRVSEN
HHHHHHHEEEEECCC
23954790
359AcetylationMAVEGVLKRFELQGS
HHHHHHHHHEEECCC
23576753
453PhosphorylationGGKGCGKTVIAKNFA
CCCCCCHHHHHHHHH
23926118
508 (in isoform 2)Acetylation--
508AcetylationVSAAREGKLVLLDGI
HHHHHCCCEEEEECC
23201123
555UbiquitinationRYLSLKEKLQLTDEQ
CCCCHHHHHCCCHHH
22790023
612SuccinylationHHMKPLVKSEEIQVI
HHCCCCCCHHHHHHH
23954790
620SuccinylationSEEIQVIKETVPNVP
HHHHHHHHHHCCCCC
23954790
633AcetylationVPQEALEKLLSVTHK
CCHHHHHHHHHHHHH
23954790
670 (in isoform 2)Acetylation--
670AcetylationRISRRLSKYPSENLH
HHHHHHHCCCCCCHH
23201123
699AcetylationLAQSALEKNLADAAI
HHHHHHHHHHHHHHH
23954790
857S-nitrosocysteineKAPTNVTCILKTLVE
CCCCCEEEEEEHHHH
-
953AcetylationVPEPVLQKLVAAFGE
CCHHHHHHHHHHHHH
23954790
988UbiquitinationNIVKHLQKFPTEGLS
HHHHHHHHCCCCCHH
22790023
988AcetylationNIVKHLQKFPTEGLS
HHHHHHHHCCCCCHH
23864654
988 (in isoform 2)Acetylation--
1029AcetylationYGIPIGAKPTNVQLA
HCCCCCCCCCCCCCC
23954790
1037 (in isoform 2)Acetylation--
1037AcetylationPTNVQLAKEFPLPEK
CCCCCCCCCCCCCCC
23201123
1045PhosphorylationEFPLPEKTFMGYWIV
CCCCCCCEEEEEEEE
20469934
1064S-nitrosocysteineNGMQKVLCPAETNHV
CCCEEEECCCCCCCC
-
1074AcetylationETNHVDIKGPVLVNM
CCCCCCCCCCEEECC
23864654
1083AcetylationPVLVNMEKYPIEKHE
CEEECCEECCCCCHH
23201123
1083UbiquitinationPVLVNMEKYPIEKHE
CEEECCEECCCCCHH
22790023
1095PhosphorylationKHEARFLSFTEECTS
CHHHHEECCCCCHHC
25338131
1175PhosphorylationVTVAPLGSPLRGQVV
EEEEECCCCCCCEEE
27149854
1221AcetylationKKSSWWSKEEGETYR
CCCCCCCHHCCCCCE
23954790
1317PhosphorylationMLKEELPSTGFGVTQ
EEECCCCCCCCCCCC
23140645
1318PhosphorylationLKEELPSTGFGVTQE
EECCCCCCCCCCCCC
23140645
1323PhosphorylationPSTGFGVTQETEFCI
CCCCCCCCCCEEEEC
23140645
1326PhosphorylationGFGVTQETEFCIPDK
CCCCCCCEEEECCCC
23140645
1351AcetylationLTSAVGQKIASPNRI
HHHHHHHHCCCCCCC
23864654
1360PhosphorylationASPNRILSDENSHAT
CCCCCCCCCCCCCCE
30635358
1364PhosphorylationRILSDENSHATIVVG
CCCCCCCCCCEEEEC
30635358
1367PhosphorylationSDENSHATIVVGFPD
CCCCCCCEEEECCCC
30635358
1377PhosphorylationVGFPDLMSPSEVYSW
ECCCCCCCHHHHHCC
30635358
1379PhosphorylationFPDLMSPSEVYSWKR
CCCCCCHHHHHCCCC
30635358
1382PhosphorylationLMSPSEVYSWKRSSS
CCCHHHHHCCCCCCC
30635358
1383PhosphorylationMSPSEVYSWKRSSSL
CCHHHHHCCCCCCCC
30635358
1396PhosphorylationSLRQPSVTSMTMYTG
CCCCCCCCEEEEECC
20139300
1399PhosphorylationQPSVTSMTMYTGKRT
CCCCCEEEEECCCCC
20139300
1401PhosphorylationSVTSMTMYTGKRTNA
CCCEEEEECCCCCCC
20139300
1415S-nitrosocysteineATPRHNNCVTLTHTN
CCCCCCCCEEEEECC
-
1539PhosphorylationSDKHVQITIERDSNE
CCCCEEEEEECCCCC
28973931
1544PhosphorylationQITIERDSNEDVSDP
EEEEECCCCCCCCCC
21659604
1584UbiquitinationDTAGLGGKGGPYRLD
CCCCCCCCCCCCCCC
22790023
1597PhosphorylationLDAGHPVYQVSEVEK
CCCCCCEEEEECCCC
23140645
1600PhosphorylationGHPVYQVSEVEKDAV
CCCEEEEECCCCCCC
23140645
1612AcetylationDAVPEDVKRAAREMA
CCCCHHHHHHHHHHH
2393719
1628UbiquitinationKAFQQRLKEIQMSEY
HHHHHHHHHHHCCCC
22790023
1707PhosphorylationDLEPQLGSPQQKPKR
CCCCCCCCCCCCCCC
20469934
1757AcetylationENYEEKFKYDIAGHS
HCHHHHHCCEECCCC
23201123
1874PhosphorylationQAARLQRTLPAGRSF
HHHHHHHHCCCCCCE
-
1887SuccinylationSFIAMDTKKIPQILQ
CEEEECCCHHHHHHH
23954790
1887AcetylationSFIAMDTKKIPQILQ
CEEEECCCHHHHHHH
23954790
1888AcetylationFIAMDTKKIPQILQQ
EEEECCCHHHHHHHH
2415387

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VWA8_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VWA8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VWA8_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of VWA8_MOUSE !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VWA8_MOUSE

loading...

Related Literatures of Post-Translational Modification

TOP