HERC4_MOUSE - dbPTM
HERC4_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HERC4_MOUSE
UniProt AC Q6PAV2
Protein Name Probable E3 ubiquitin-protein ligase HERC4
Gene Name Herc4
Organism Mus musculus (Mouse).
Sequence Length 1057
Subcellular Localization Cytoplasm, cytosol .
Protein Description Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates..
Protein Sequence MLCWGNASYGQLGLGGIDEEIVLEPRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVACGEAHTLALNDKGQVYAWGLDSDGQLGLQGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFSYNGQCPQDIGSEDYFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCSDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAISNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDCNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKTGQLIQYDKFYIHEVQELIDIRNDYINWVQQQAYGVDVSHGVTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPAVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNRQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWADHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSLI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
34UbiquitinationRSDFFVNKKVRDVGC
HHCCCCCCCHHCCCC		47.5522790023
133PhosphorylationRVPRNIKSLSDIQIV
CCCCCCCCCCCCHHH		29.3426745281
135PhosphorylationPRNIKSLSDIQIVQV
CCCCCCCCCCHHHHH		39.4926745281
237UbiquitinationRYVPNLLKSLRSQKI
CCHHHHHHHHCCCCE		51.0822790023
317PhosphorylationVPSSGRIYSFGLGGN
ECCCCCEEEEECCCC		9.1525293948
318PhosphorylationPSSGRIYSFGLGGNG
CCCCCEEEEECCCCC		15.5125293948
329PhosphorylationGGNGQLGTGSTSNRK
CCCCCCCCCCCCCCC		36.2325293948
331PhosphorylationNGQLGTGSTSNRKSP
CCCCCCCCCCCCCCC		28.6225293948
332PhosphorylationGQLGTGSTSNRKSPF
CCCCCCCCCCCCCCC		31.2225293948
333PhosphorylationQLGTGSTSNRKSPFT
CCCCCCCCCCCCCCE		36.0125293948
361PhosphorylationQDIGSEDYFCVKRIF
CCCCCCCEEEEEEEE		8.53-
469UbiquitinationAARLLFHKLIQPDHP
HHHHHHHHHHCCCCH		39.6922790023
488UbiquitinationQVAASLEKNLIPKLT
HHHHHHHHCCHHHHH		63.4522790023
493UbiquitinationLEKNLIPKLTSSLPD
HHHCCHHHHHCCCCC		58.3622790023
606UbiquitinationILHRVNEKTGQLIQY
HHHHHHHHCCCEEEE		53.3922790023
740UbiquitinationDYKKPLKVIFVGEDA
CCCCCCEEEEEECCC		5.6027667366
748UbiquitinationIFVGEDAVDAGGVRK
EEEECCCCCCCCHHH		8.8427667366
774UbiquitinationDPKYGMFRYYEDSRL
CCCCCCEEEECCCEE		25.0027667366
782UbiquitinationYYEDSRLIWFSDKTF
EECCCEEEEEECCCC		3.2027667366
822PhosphorylationHFPLALYKKLLKRKP
HHHHHHHHHHHHCCC		37.4824719451
830PhosphorylationKLLKRKPSLDDLKEL
HHHHCCCCHHHHHHH		47.6830352176
835UbiquitinationKPSLDDLKELMPAVG
CCCHHHHHHHHHHHH		56.6622790023
874UbiquitinationTVENFGATEVKELVL
EEECCCCCCHHHHHH		41.5127667366
882UbiquitinationEVKELVLNGADTAVN
CHHHHHHCCCCCHHH		35.8127667366
908UbiquitinationVDYIFNKSVASLFDA
HHHHHCHHHHHHHHH		24.8227667366
916UbiquitinationVASLFDAFHAGFHKV
HHHHHHHHHCHHHHH		4.3427667366
933UbiquitinationGKVLLLFQPNELQAM
CEEEEEECCCCEEEE		39.6227667366
959UbiquitinationLEKNTEYKGEYWADH
HHHCCCCCCCCCCCC		38.7522790023
967UbiquitinationGEYWADHPTIKIFWE
CCCCCCCCHHHHHHH		36.0427667366
995UbiquitinationLLFLTGSDRIPILGM
EEEEECCCCCEECCC		54.6027667366
1003UbiquitinationRIPILGMKSLKLVIQ
CCEECCCCEEEEEEE		51.3327667366
1025GlutathionylationYLPVSHTCFNLLDLP
EEEECCCEECHHCCC		1.4624333276
1029UbiquitinationSHTCFNLLDLPKYTE
CCCEECHHCCCCCCC		7.1527667366
1037UbiquitinationDLPKYTEKETLRCKL
CCCCCCCHHHHCEEE		48.4727667366
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HERC4_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HERC4_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HERC4_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HERC4_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HERC4_MOUSE

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Related Literatures of Post-Translational Modification

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