| UniProt ID | YMEL1_MOUSE | |
|---|---|---|
| UniProt AC | O88967 | |
| Protein Name | ATP-dependent zinc metalloprotease YME1L1 | |
| Gene Name | Yme1l1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 715 | |
| Subcellular Localization | Mitochondrion inner membrane . Mitochondrion . | |
| Protein Description | ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (By similarity). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure. [PubMed: 17709429] | |
| Protein Sequence | MFSLSSTVQPQVTIPLSHLINAFHSPKNISVSVNTPVSQKQHRDTVPEHEAPSSEPVLNLRDLGLSELKIGQIDKMVENLLPGFYKDKRVSSCWHTSHISAQSFFENKYGHLDMFSTLRSSSLYRQHPKTLRSICSDLQYFPVFIQSRGFKTLKSRTRRLQSTSERLVEAQNIAPSFVKGFLLRDRGTDLESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTVLGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDKSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRESYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 30 | Phosphorylation | FHSPKNISVSVNTPV HCCCCCEEEEECCCC | 20.10 | - | |
| 32 | Phosphorylation | SPKNISVSVNTPVSQ CCCCEEEEECCCCCC | 11.67 | - | |
| 35 | Phosphorylation | NISVSVNTPVSQKQH CEEEEECCCCCCCCC | 23.94 | - | |
| 38 | Phosphorylation | VSVNTPVSQKQHRDT EEECCCCCCCCCCCC | 32.63 | - | |
| 69 | Ubiquitination | DLGLSELKIGQIDKM HHCCCCCCHHHHHHH | 40.51 | - | |
| 162 | Phosphorylation | SRTRRLQSTSERLVE HHHHHHHHHHHHHHH | 38.19 | - | |
| 163 | Phosphorylation | RTRRLQSTSERLVEA HHHHHHHHHHHHHHH | 22.96 | 22817900 | |
| 179 | Ubiquitination | NIAPSFVKGFLLRDR HHCHHHHHHHHHCCC | 41.77 | - | |
| 200 | Ubiquitination | LDKLMKTKNIPEAHQ HHHHHHCCCCCHHHH | 47.57 | 27667366 | |
| 275 | Ubiquitination | SAVDPVQMKNVTFEH CCCCCEECCCCCHHH | 3.29 | 27667366 | |
| 392 | Phosphorylation | VGGKRIESPMHPYSR CCCEECCCCCCCCCH | 25.75 | 25338131 | |
| 644 | Phosphorylation | SEKLGVMTYSDTGKL CCCCCCEECCCCCCC | 19.91 | 28066266 | |
| 645 | Phosphorylation | EKLGVMTYSDTGKLS CCCCCEECCCCCCCC | 6.10 | 29472430 | |
| 646 | Phosphorylation | KLGVMTYSDTGKLSP CCCCEECCCCCCCCH | 21.38 | 28066266 | |
| 648 | Phosphorylation | GVMTYSDTGKLSPET CCEECCCCCCCCHHH | 30.21 | 28066266 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of YMEL1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of YMEL1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of YMEL1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of YMEL1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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